ANXA9 - annexin A9 Gene

中文名称：膜联蛋白 A9

种属: Homo sapiens

同用名: ANX31

关于 ANXA9

功能概要

膜联蛋白是钙依赖性磷脂结合蛋白家族。膜联蛋白家族的成员包含 4 个内部重复结构域，每个结构域都包含一个 II 型钙结合位点。钙结合位点是膜联蛋白聚集和协同结合阴离子磷脂和细胞外基质蛋白所必需的。该基因编码膜联蛋白家族的一个不同成员，其中保守四分体核心中的所有四个同源 II 型钙结合位点都包含消除其功能的氨基酸取代。然而，结构分析表明，由四分体核心形成的保守推定离子通道是完整的。[RefSeq 提供，2008 年 7 月]

The annexins are a family of calcium-dependent phospholipid-binding proteins. Members of the annexin family contain 4 internal repeat domains, each of which includes a type II calcium-binding site. The calcium-binding sites are required for annexins to aggregate and cooperatively bind anionic Phospholipids and extracellular matrix proteins. This gene encodes a divergent member of the annexin protein family in which all four homologous type II calcium-binding sites in the conserved tetrad core contain amino acid substitutions that ablate their function. However, structural analysis suggests that the conserved putative ion channel formed by the tetrad core is intact. [provided by RefSeq, Jul 2008]