HSPA6 - heat shock protein family A (Hsp70) member 6 Gene

中文名称：热休克蛋白家族 A (Hsp70) 成员 6

种属: Homo sapiens

同用名: HSP70B'

基因 ID: 3310 | 基因类型: protein coding

关于 HSPA6

Cytogenetic location: 1q23.3 Genomic coordinates (GRCh38): 1:161,524,540-161,526,894 (from NCBI)

This gene has 1 transcript (splice variant), 52 orthologues and 13 paralogues.

功能概要

启用酶结合活性；热休克蛋白结合活性；和未折叠的蛋白结合活性。参与细胞对热和蛋白质重折叠的反应。位于中心粒和细胞质中。与 COP9 信号体共定位。 [由基因组资源联盟提供，2022 年 4 月]

Enables Enzyme binding activity; heat shock protein binding activity; and unfolded protein binding activity. Involved in cellular response to heat and protein refolding. Located in centriole and cytosol. Colocalizes with COP9 signalosome. [provided by Alliance of Genome Resources, Apr 2022]

HSPA6 基因产物(1)

mRNA	Protein	Name
NM_002155.5	NP_002146.2	heat shock 70 kDa protein 6

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables ATP hydrolysis activity	IDA IDA: 通过直接分析推断	21231916	GOA
enables enzyme binding	IPI IPI: 通过物理相互作用推断	23921388	GOA
enables heat shock protein binding	IPI IPI: 通过物理相互作用推断	21231916	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	21044950	GOA
enables unfolded protein binding	IDA IDA: 通过直接分析推断	21231916	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
NOT involved in cellular heat acclimation	IMP IMP: 通过突变表型推断	21231916	GOA
involved in cellular response to heat	IDA IDA: 通过直接分析推断	24061851	GOA
involved in cellular response to heat	IMP IMP: 通过突变表型推断	21597468	GOA
involved in protein refolding	IDA IDA: 通过直接分析推断	21231916	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of COP9 signalosome	IDA IDA: 通过直接分析推断	18850735	GOA
located in centriole	IDA IDA: 通过直接分析推断	24061851	GOA
located in cytoplasm	IDA IDA: 通过直接分析推断	24061851	GOA
located in cytosol	IDA IDA: 通过直接分析推断	21231916	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

HSPA6 蛋白结构

HSP70

0
100
200
300
400
500
600
643 a.a.

蛋白主名

其他名称

heat shock 70 kDa protein 6

epididymis secretory sperm binding protein

HSPA6 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	HSPA6	P17066	C22orf15	Homo sapiens	Q8WYQ4-2	Validated Y2H	32296183
种属内	HSPA6	P17066	COMMD6	Homo sapiens	Q7Z4G1	Validated Y2H	32296183
种属内	HSPA6	P17066	PRAP1	Homo sapiens	Q96NZ9	Validated Y2H	32296183
种属内	HSPA6	P17066	BAG4	Homo sapiens	O95429	Y2H Prey Pooling	32296183
种属内	HSPA6	P17066	BAG4	Homo sapiens	O95429	Y2H Array	32296183
种属内	HSPA6	P17066	LGALS7	Homo sapiens	P47929	Validated Y2H	32296183
种属内	HSPA6	P17066	PPIB	Homo sapiens	P23284	Validated Y2H	32296183
种属内	HSPA6	P17066	RPA1	Homo sapiens	P27694	Validated Y2H	32296183
种属内	HSPA6	P17066	TERF1	Homo sapiens	P54274	BiFC	21044950
种属内	HSPA6	P17066	TERF1	Homo sapiens	P54274	Pull Down	21044950
种属内	HSPA6	P17066	KRT222	Homo sapiens	Q8N1A0	Validated Y2H	32296183
种属内	HSPA6	P17066	FLNA	Homo sapiens	P21333-2	Validated Y2H	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Hepatocellular Carcinoma

Liver Cancer	Primary Liver Cancer
HCC	Hepatoma
Malignant Neoplasm Of Liver	Liver Neoplasms
Cancer, Hepatocellular	Liver Cell Carcinoma
Lcc	Hepatoblastoma, Somatic
Hepatic Cancer	Primary Malignant Neoplasm Of Liver
Rare Tumor Of Liver And Intrahepatic Biliary Tract	Hepatocellular Carcinoma, Somatic
Hepatocellular Carcinoma, Childhood Type, Somatic	Hepatocellular Cancer, Somatic
Ca Liver - Primary	Hepatic Neoplasm
Malignant Hepato-Biliary Neoplasm	Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary
Malignant Neoplasm Of Liver, Primary	Malignant Tumor Of Liver
Neoplasm Of Liver	Non-Resectable Primary Hepatic Malignant Neoplasm
Resectable Malignant Neoplasm Of Liver	Resectable Malignant Neoplasm Of The Liver
Primary Liver Carcinoma	Primary Malignant Liver Neoplasm
Primary Cancer Of Liver	Primary Tumor Of The Liver
Rare Tumor Of Liver And Ibt	Hepatocellular Cancer
Neoplasm Of The Liver	Carcinoma, Hepatocellular
Hepatomas	Liver Neoplasm
Liver Carcinoma	Liver And Intrahepatic Biliary Tract Carcinoma
Malignant Hepatobiliary Neoplasm	Adult Primary Hepatocellular Carcinoma
Hepatoblastoma	Carcinoma Of Liver
Malignant Liver Tumour	Malignant Hepatic Tumour

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS06435	HSPA6 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	HSPA6	RGD	RGD:1586661
Bos taurus	HSPA6	VGNC	VGNC:55236

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

HSPA6 - heat shock protein family A (Hsp70) member 6 Gene

关于 HSPA6

功能概要

HSPA6 基因产物(1)

HSPA6 蛋白结构

HSPA6 蛋白互作信息

关联疾病

直系同源

热门区域

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HSPA6 - heat shock protein family A (Hsp70) member 6 Gene

关于 HSPA6

功能概要

HSPA6 基因产物(1)

HSPA6 蛋白结构

HSPA6 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z