2. Gene
  3. PRAP1 - proline rich acidic protein 1 Gene

PRAP1 - proline rich acidic protein 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：富脯氨酸的酸性蛋白 1

种属: Homo sapiens

同用名: UPA; PRO1195

基因 ID: 118471 | 基因类型: protein coding

关于 PRAP1

Cytogenetic location: 10q26.3 Genomic coordinates (GRCh38): 10:133,347,373-133,352,683 (from NCBI)

This gene has 2 transcripts (splice variants) and 70 orthologues. Biased expression in small intestine (RPKM 388.5), duodenum (RPKM 348.9) and 3 other tissues.

功能概要

预测启用甘油三酯结合活性。参与 DNA 损伤反应，p53 类介质的信号转导导致细胞周期停滞；停用有丝分裂纺锤体组装检查点；和细胞凋亡过程的负调控。预测位于内质网和细胞外区域。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable triglyceride binding activity. Involved in DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; deactivation of mitotic spindle assembly checkpoint; and negative regulation of apoptotic process. Predicted to be located in endoplasmic reticulum and extracellular region. [provided by Alliance of Genome Resources, Apr 2022]

PRAP1 基因产物(2)

mRNA Protein Name
NM_001145201.2 NP_001138673.1 proline-rich acidic protein 1 isoform 2 precursor
NM_145202.5 NP_660203.3 proline-rich acidic protein 1 isoform 1 precursor
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
24374861 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in DNA damage response IDA
IDA: 通过直接分析推断
23235459 GOA
involved in DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest IMP
IMP: 通过突变表型推断
23235459 GOA
involved in deactivation of mitotic spindle assembly checkpoint IDA
IDA: 通过直接分析推断
24374861 GOA
involved in negative regulation of apoptotic process IMP
IMP: 通过突变表型推断
23235459 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PRAP1 蛋白结构

PRAP

PRAP: Proline-rich acidic protein 1, pregnancy-specific uterine (105 - 149)

  • 0
  • 100
  • 151 a.a.
蛋白主名 其他名称

proline-rich acidic protein 1

epididymis secretory sperm binding protein

PRAP1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
PRAP1 Q96NZ9 UBQLN1 Homo sapiens Q9UMX0-2
Y2H Prey Pooling
25416956
种属内
PRAP1 Q96NZ9 UBQLN1 Homo sapiens Q9UMX0-2
Y2H Array
25416956
种属内
PRAP1 Q96NZ9 UBQLN1 Homo sapiens Q9UMX0-2
Validated Y2H
25416956
种属内
PRAP1 Q96NZ9 MEOX2 Homo sapiens Q6FHY5
Y2H Array
32296183
种属内
PRAP1 Q96NZ9 MEOX2 Homo sapiens Q6FHY5
Y2H Prey Pooling
32296183
种属内
PRAP1 Q96NZ9 SGTA Homo sapiens O43765
Y2H Prey Pooling
32296183
种属内
PRAP1 Q96NZ9 SGTA Homo sapiens O43765
Y2H Prey Pooling
25416956
种属内
PRAP1 Q96NZ9 SGTA Homo sapiens O43765
Y2H Array
32296183
种属内
PRAP1 Q96NZ9 HSPA6 Homo sapiens P17066
Y2H Prey Pooling
32296183
种属内
PRAP1 Q96NZ9 HSPA6 Homo sapiens P17066
Y2H Array
32296183
种属内
PRAP1 Q96NZ9 UBQLN1 Homo sapiens Q9UMX0
Y2H Prey Pooling
32296183
种属内
PRAP1 Q96NZ9 UBQLN1 Homo sapiens Q9UMX0
Validated Y2H
32296183
种属内
PRAP1 Q96NZ9 UBQLN1 Homo sapiens Q9UMX0
Y2H Array
25416956
种属内
PRAP1 Q96NZ9 UBQLN1 Homo sapiens Q9UMX0
Y2H Array
32296183
种属内
PRAP1 Q96NZ9 UBQLN2 Homo sapiens Q9UHD9
Y2H Prey Pooling
32296183
种属内
PRAP1 Q96NZ9 UBQLN2 Homo sapiens Q9UHD9
Validated Y2H
32296183
种属内
PRAP1 Q96NZ9 UBQLN2 Homo sapiens Q9UHD9
Y2H Array
32296183
种属内
PRAP1 Q96NZ9 MRFAP1 Homo sapiens Q9Y605
Validated Y2H
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 PRAP1 蛋白

目录号 产品名 蛋白编号 纯度
HY-P71004 PRAP1 Protein, Human (HEK293, His) Q96NZ9/AAL16670.1 (V21-Q151) ≥95%

关联疾病

疾病名称 别名
Hepatocellular Carcinoma

Liver Cancer

Primary Liver Cancer

HCC

Hepatoma

Malignant Neoplasm Of Liver

Liver Neoplasms

Cancer, Hepatocellular

Liver Cell Carcinoma

Lcc

Hepatoblastoma, Somatic

Hepatic Cancer

Primary Malignant Neoplasm Of Liver

Rare Tumor Of Liver And Intrahepatic Biliary Tract

Hepatocellular Carcinoma, Somatic

Hepatocellular Carcinoma, Childhood Type, Somatic

Hepatocellular Cancer, Somatic

Ca Liver - Primary

Hepatic Neoplasm

Malignant Hepato-Biliary Neoplasm

Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary

Malignant Neoplasm Of Liver, Primary

Malignant Tumor Of Liver

Neoplasm Of Liver

Non-Resectable Primary Hepatic Malignant Neoplasm

Resectable Malignant Neoplasm Of Liver

Resectable Malignant Neoplasm Of The Liver

Primary Liver Carcinoma

Primary Malignant Liver Neoplasm

Primary Cancer Of Liver

Primary Tumor Of The Liver

Rare Tumor Of Liver And Ibt

Hepatocellular Cancer

Neoplasm Of The Liver

Carcinoma, Hepatocellular

Hepatomas

Liver Neoplasm

Liver Carcinoma

Liver And Intrahepatic Biliary Tract Carcinoma

Malignant Hepatobiliary Neoplasm

Adult Primary Hepatocellular Carcinoma

Hepatoblastoma

Carcinoma Of Liver

Malignant Liver Tumour

Malignant Hepatic Tumour
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS11050 PRAP1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus PRAP1 RGD RGD:61876
Canis familiaris PRAP1 VGNC VGNC:53010
Mus musculus PRAP1 MGD MGI:893573
Bos taurus PRAP1 VGNC VGNC:55965
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z