SLC23A1 - solute carrier family 23 member 1 Gene

中文名称：溶质载体家族 23 成员 1

种属: Homo sapiens

同用名: SVCT1; YSPL3; SLC23A2

基因 ID: 9963 | 基因类型: protein coding

关于 SLC23A1

Cytogenetic location: 5q31.2 Genomic coordinates (GRCh38): 5:139,367,196-139,385,676 (from NCBI)

This gene has 7 transcripts (splice variants), 200 orthologues and 2 paralogues. Biased expression in small intestine (RPKM 24.6), kidney (RPKM 21.3) and 4 other tissues.

功能概要

维生素 C 被人体吸收并分布到器官需要两种钠依赖性维生素 C 转运蛋白。该基因编码两种转运蛋白之一。编码的蛋白质在涉及上皮表面的散装维生素 C 运输中具有活性。此前，该基因的官方符号为 SLC23A2。已发现该基因编码不同亚型的可变剪接转录物变体。[RefSeq 提供，2008 年 12 月]

The absorption of vitamin C into the body and its distribution to organs requires two sodium-dependent vitamin C transporters. This gene encodes one of the two transporters. The encoded protein is active in bulk vitamin C transport involving epithelial surfaces. Previously, this gene had an official symbol of SLC23A2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]

SLC23A1 基因产物(2)

mRNA	Protein	Name
NM_005847.5	NP_005838.3	solute carrier family 23 member 1 isoform a
NM_152685.4	NP_689898.2	solute carrier family 23 member 1 isoform b

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
NOT enables L-ascorbate:sodium symporter activity	IDA IDA: 通过直接分析推断	10556483	GOA
enables L-ascorbate:sodium symporter activity	IDA IDA: 通过直接分析推断	10556483	GOA
enables L-ascorbic acid transmembrane transporter activity	IDA IDA: 通过直接分析推断	10631088	GOA
enables dehydroascorbic acid transmembrane transporter activity	IMP IMP: 通过突变表型推断	18247577	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	17474147	GOA
enables sodium ion transmembrane transporter activity	IDA IDA: 通过直接分析推断	18094143	GOA
enables urate transmembrane transporter activity	IDA IDA: 通过直接分析推断	36749388	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
NOT involved in L-ascorbic acid transmembrane transport	IDA IDA: 通过直接分析推断	10556483	GOA
involved in L-ascorbic acid transmembrane transport	IDA IDA: 通过直接分析推断	10556483	GOA
involved in dehydroascorbic acid transport	IMP IMP: 通过突变表型推断	18247577	GOA
involved in response to toxic substance	IDA IDA: 通过直接分析推断	17575980	GOA
involved in sodium ion transport	IDA IDA: 通过直接分析推断	18094143	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in apical plasma membrane	IDA IDA: 通过直接分析推断	15993839	GOA
located in intracellular organelle	IDA IDA: 通过直接分析推断	15993839	GOA
located in plasma membrane	IDA IDA: 通过直接分析推断	10631088	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

蛋白主名

其他名称

solute carrier family 23 member 1

Na(+)/L-ascorbic acid transporter 1

SLC23A1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	SLC23A1	Q9UHI7	KRTAP10-8	Homo sapiens	P60410	Y2H Array	25416956
Intra	SLC23A1	Q9UHI7	KRTAP10-9	Homo sapiens	P60411	Y2H Prey Pooling	25416956
Intra	SLC23A1	Q9UHI7	KRTAP10-9	Homo sapiens	P60411	Validated Y2H	25416956
Intra	SLC23A1	Q9UHI7	KRTAP10-5	Homo sapiens	P60370	Y2H Prey Pooling	25416956
Intra	SLC23A1	Q9UHI7	KRTAP10-7	Homo sapiens	P60409	Validated Y2H	25416956
Intra	SLC23A1	Q9UHI7	KRTAP4-2	Homo sapiens	Q9BYR5	Validated Y2H	25416956
Intra	SLC23A1	Q9UHI7	ADAMTSL4	Homo sapiens	Q6UY14-3	Validated Y2H	25416956
Intra	SLC23A1	Q9UHI7	AHCYL1	Homo sapiens	O43865	Y2H Array	25416956
Intra	SLC23A1	Q9UHI7	AHCYL1	Homo sapiens	O43865	Validated Y2H	25416956
Intra	SLC23A1	Q9UHI7	MTUS2	Homo sapiens	Q5JR59	Validated Y2H	25416956
Intra	SLC23A1	Q9UHI7	MTUS2	Homo sapiens	Q5JR59	Y2H Array	25416956
Intra	SLC23A1	Q9UHI7	MTUS2	Homo sapiens	Q5JR59	Y2H Prey Pooling	25416956
Intra	SLC23A1	Q9UHI7	NOTCH2NLA	Homo sapiens	Q7Z3S9	Y2H Array	25416956
Intra	SLC23A1	Q9UHI7	NOTCH2NLA	Homo sapiens	Q7Z3S9	Validated Y2H	25416956
Intra	SLC23A1	Q9UHI7	NOTCH2NLA	Homo sapiens	Q7Z3S9	Y2H Prey Pooling	25416956

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Hypoascorbemia

Scurvy	Ascorbic Acid Deficiency
Vitamin C Deficiency	Vitamin C, Inability To Synthesize
Deficiency Of Vitamin C	Scorbutus
Vitamin C

Aggressive Periodontitis

Juvenile Periodontitis	Periodontitis, Juvenile
Prepubertal Periodontitis

Hemophagocytic Lymphohistiocytosis, Familial, 2

Familial Hemophagocytic Lymphohistiocytosis 2	FHL2
Hplh2	Hlh2
Hemophagocytic Lymphohistiocytosis, Familial, 2, Susceptibility To	Lymphohistiocytosis, Hemophagocytic, Familial, Type 2

Osmotic Diarrhea

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS13081	SLC23A1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Felis catus	SLC23A1	VGNC	VGNC:65247
Rattus norvegicus	SLC23A1	RGD	RGD:619875
Canis familiaris	SLC23A1	VGNC	VGNC:46282
Macaca mulatta	SLC23A1	VGNC	VGNC:77423
Bos taurus	SLC23A1	VGNC	VGNC:34733
Mus musculus	SLC23A1	MGD	MGI:1341903

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