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  2. SYT11 - synaptotagmin 11 Gene

SYT11 - synaptotagmin 11 Gene

中文名称:突触结合蛋白 11

种属: Homo sapiens

同用名: SYT12; sytXI

基因 ID: 23208 | 基因类型: protein coding

关于 SYT11

Cytogenetic location: 1q22 Genomic coordinates (GRCh38): 1:155,859,567-155,885,199 (from NCBI)

This gene has 1 transcript (splice variant), 230 orthologues and 31 paralogues. Biased expression in brain (RPKM 160.9), adrenal (RPKM 11.8) and 1 other tissue.

功能概要

该基因是突触结合蛋白基因家族的成员,编码的蛋白质与其他家族成员相似,这些成员是已知的钙传感器,可介导突触传递中膜运输的钙依赖性调节。编码的蛋白质也是泛素-E3-连接酶帕金蛋白的底物。该基因以前被称为突触结合蛋白 XII,但已更名为突触结合蛋白 XI 以与小鼠和大鼠的官方命名法一致。[RefSeq 提供,2010 年 4 月]

This gene is a member of the synaptotagmin gene family and encodes a protein similar to Other family members that are known calcium sensors and mediate calcium-dependent regulation of membrane trafficking in synaptic transmission. The encoded protein is also a substrate for ubiquitin-E3-ligase parkin. The gene has previously been referred to as synaptotagmin XII but has been renamed synaptotagmin XI to be consistent with mouse and rat official nomenclature. [provided by RefSeq, Apr 2010]

SYT11 基因产物(1)

mRNA Protein Name
NM_152280.5 NP_689493.3 synaptotagmin-11
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
16189514 GOA
enables ubiquitin protein ligase binding IPI
IPI: 通过物理相互作用推断
12925569 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in autophagy IMP
IMP: 通过突变表型推断
27278822 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in neuron projection IDA
IDA: 通过直接分析推断
12925569 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

SYT11 蛋白结构

C2

C2: C2 domain (174 - 261)

C2

C2: C2 domain (309 - 396)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 431 a.a.
蛋白主名 其他名称

synaptotagmin-11

synaptotagmin 12

SYT11 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
SYT11 Q9BT88 PRKN Homo sapiens O60260-5
Y2H Pooling
32814053
种属内
SYT11 Q9BT88 PRKN Homo sapiens O60260-5
Validated Y2H
32814053
种属内
SYT11 Q9BT88 PRKN Homo sapiens O60260-5
Y2H Array
32814053
种属内
SYT11 Q9BT88 SGTA Homo sapiens O43765
Validated Y2H
25416956
种属内
SYT11 Q9BT88 SGTA Homo sapiens O43765
Y2H Array
32296183
种属内
SYT11 Q9BT88 SGTA Homo sapiens O43765
Y2H Array
25416956
种属内
SYT11 Q9BT88 SGTA Homo sapiens O43765
Y2H Prey Pooling
32296183
种属内
SYT11 Q9BT88 SGTA Homo sapiens O43765
Y2H
21516116
种属内
SYT11 Q9BT88 ATP13A2 Homo sapiens Q9NQ11
Anti Tag CoIP
22645275
种属内
SYT11 Q9BT88 SGTB Homo sapiens Q96EQ0
Y2H Prey Pooling
32296183
种属内
SYT11 Q9BT88 SGTB Homo sapiens Q96EQ0
Y2H Array
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Schizophrenia

SCZD

Schizophrenia With Or Without An Affective Disorder

Schizophrenia 12

Schizophrenia, Susceptibility To

Schizophrenia-1

Dementia Praecox

Schizophrenia 1

Parkinson Disease, Late-Onset

Parkinson Disease

Parkinson'S Disease

PD

PARK

Parkinson Disease, Susceptibility To

Late Onset Parkinson'S Disease

Late Onset Parkinson Disease

Paralysis Agitans

Primary Parkinsonism

Idiopathic Parkinson Disease

Parkinson'S

Parkinson Disease, Late-Onset, Susceptibility To

Parkinson Disease, Age Of Onset, Modifier

Lewy Body Parkinson Disease

Idiopathic Parkinson'S Disease

Pd - [Parkinson Disease]

Parkinson Disease Nos

Parkinson, Nos

Primary Parkinson Disease

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Mus musculus SYT11 MGD MGI:1859547
Bos taurus SYT11 VGNC VGNC:35537
Canis familiaris SYT11 VGNC VGNC:47042
Felis catus SYT11 VGNC VGNC:65893
Macaca mulatta SYT11 VGNC VGNC:78167
Rattus norvegicus SYT11 RGD RGD:62042