SELENOV - selenoprotein V Gene

中文名称：硒蛋白 V

种属: Homo sapiens

同用名: SELV

关于 SELENOV

功能概要

该基因编码含有硒代半胱氨酸 (Sec) 残基的硒蛋白，该残基由通常发出翻译终止信号的 UGA 密码子编码。硒蛋白 mRNA 的 3' UTR 包含一个保守的茎环结构，即 Sec 插入序列 (SECIS) 元件，这是将 UGA 识别为 Sec 密码子而不是终止信号所必需的。这种蛋白质在睾丸中特异性表达。它属于 SelWTH 家族，具有硫氧还蛋白样折叠和保守的 CxxU (C 是半胱氨酸，U 是 Sec) 基序，表明该基因具有氧化还原功能。已发现该基因的可变剪接转录本变体。[RefSeq 提供，2017 年 4 月]

This gene encodes a selenoprotein containing a selenocysteine (Sec) residue, which is encoded by the UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element, which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This protein is specifically expressed in the testis. It belongs to the SelWTH family, which possesses a thioredoxin-like fold and a conserved CxxU (C is cysteine, U is Sec) motif, suggesting a redox function for this gene. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Apr 2017]