RNF128 - ring finger protein 128 Gene

中文名称：无名指蛋白 128

种属: Homo sapiens

同用名: GRAIL

关于 RNF128

功能概要

该基因编码的蛋白质是一种 I 型跨膜蛋白，定位于内吞途径。该蛋白质包含一个 RING 锌指基序，并已被证明具有 E3 泛素连接酶活性。该基因在逆转录病毒转导的 T 细胞杂交瘤中的表达显着抑制了激活诱导的 IL2 和 IL4 细胞因子的产生。在无能 CD4 (+) T 细胞中观察到该基因的诱导表达，这表明在无能表型的诱导中起作用。已经报道了编码不同亚型的可变剪接转录物变体。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene is a type I transmembrane protein that localizes to the endocytic pathway. This protein contains a RING zinc-finger motif and has been shown to possess E3 ubiquitin Ligase activity. Expression of this gene in retrovirally transduced T cell hybridoma significantly inhibits activation-induced IL2 and IL4 cytokine production. Induced expression of this gene was observed in anergic CD4(+) T cells, which suggested a role in the induction of anergic phenotype. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]