FXYD7 - FXYD domain containing ion transport regulator 7 Gene

中文名称：含 FXYD 结构域含离子输运调节因子 7

种属: Homo sapiens

关于 FXYD7

功能概要

该参考序列来源于多个重复的 EST，并通过相似的人类基因组序列进行验证。该基因编码一个小膜蛋白家族的成员，该家族共享一个 35 个氨基酸的特征序列域，从序列 PFXYD 开始，包含 7 个不变氨基酸和 6 个高度保守的氨基酸。该家族批准的人类基因命名法是含有离子传输调节剂的 FXYD 结构域。已经为两个家族成员 (FXYD1 和 FXYD2) 建立了跨膜拓扑结构，N 端位于细胞外，C 端位于膜的细胞质侧。 FXYD2，也称为 Na,K-ATPase 的 γ 亚基，调节该酶的特性。 FXYD1 (phospholemman) 、FXYD2 (gamma) 、FXYD3 (MAT-8) 、FXYD4 (CHIF) 和 FXYD5 (RIC) 已被证明可在实验表达系统中诱导通道活性。该基因产物 FXYD7 是新颖的，尚未被表征为蛋白质。 [RefSeq 由 Kathleen J. Sweadner 博士整理，sweadner@helix.mgh.harvard.edu.，2000 年 12 月]

This reference sequence was derived from multiple replicate ESTs and validated by similar human genomic sequence. This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved Amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that Enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. This gene product, FXYD7, is novel and has not been characterized as a protein. [RefSeq curation by Kathleen J. Sweadner, Ph.D., sweadner@helix.mgh.harvard.edu., Dec 2000]