2. Gene
  3. SLC22A6 - solute carrier family 22 member 6 Gene

SLC22A6 - solute carrier family 22 member 6 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：溶质载体家族 22 成员 6

种属: Homo sapiens

同用名: OAT1; PAHT; HOAT1; ROAT1

基因 ID: 9356 | 基因类型: protein coding

关于 SLC22A6

Cytogenetic location: 11q12.3 Genomic coordinates (GRCh38): 11:62,976,597-62,984,967 (from NCBI)

This gene has 6 transcripts (splice variants), 489 orthologues and 22 paralogues. Restricted expression toward kidney (RPKM 150.9).

功能概要

该基因编码的蛋白质参与钠依赖性转运和有机阴离子的排泄，其中一些具有潜在毒性。编码的蛋白质是一种完整的膜蛋白，可能定位于基底外侧膜。已发现该基因编码四种不同亚型的四种转录变体。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene is involved in the sodium-dependent transport and excretion of organic anions, some of which are potentially toxic. The encoded protein is an integral membrane protein and may be localized to the basolateral membrane. Four transcript variants encoding four different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

SLC22A6 基因产物(4)

mRNA Protein Name
NM_004790.5 NP_004781.2 solute carrier family 22 member 6 isoform a
NM_153276.3 NP_695008.1 solute carrier family 22 member 6 isoform b
NM_153277.3 NP_695009.1 solute carrier family 22 member 6 isoform c
NM_153278.3 NP_695010.1 solute carrier family 22 member 6 isoform d
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables alpha-ketoglutarate transmembrane transporter activity IDA
IDA: 通过直接分析推断
9950961 GOA
enables antiporter activity IDA
IDA: 通过直接分析推断
9950961 GOA
enables organic anion transmembrane transporter activity IDA
IDA: 通过直接分析推断
9950961 GOA
enables organic anion transmembrane transporter activity IMP
IMP: 通过突变表型推断
22169006 GOA
enables prostaglandin transmembrane transporter activity IDA
IDA: 通过直接分析推断
11907186 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
16189514 GOA
enables sodium-independent organic anion transmembrane transporter activity IDA
IDA: 通过直接分析推断
9887087 GOA
enables solute:inorganic anion antiporter activity IDA
IDA: 通过直接分析推断
15037815 GOA
enables transmembrane transporter activity IDA
IDA: 通过直接分析推断
26377792 GOA
enables xenobiotic transmembrane transporter activity IDA
IDA: 通过直接分析推断
14675047 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in alpha-ketoglutarate transport IDA
IDA: 通过直接分析推断
9950961 GOA
involved in organic anion transport IDA
IDA: 通过直接分析推断
9950961 GOA
involved in organic anion transport IMP
IMP: 通过突变表型推断
22169006 GOA
involved in prostaglandin transport IDA
IDA: 通过直接分析推断
11907186 GOA
involved in renal tubular secretion IMP
IMP: 通过突变表型推断
22169006 GOA
involved in sodium-independent organic anion transport IDA
IDA: 通过直接分析推断
9887087 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in basal plasma membrane IDA
IDA: 通过直接分析推断
35307651 GOA
located in basolateral plasma membrane IDA
IDA: 通过直接分析推断
9887087 GOA
located in plasma membrane IDA
IDA: 通过直接分析推断
14749323 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SLC22A6 蛋白结构

Sugar_tr

Sugar_tr: Sugar (and other) transporter (135 - 512)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 563 a.a.
蛋白主名 其他名称

solute carrier family 22 member 6

PAH transporter

SLC22A6 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
SLC22A6 Q4U2R8 APPBP2 Homo sapiens Q92624
Y2H Pooling
16189514
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Hyperuricemia

Blood Urate Raized

Uricacidemia
Fanconi-Like Syndrome

Fanconi Like Syndrome
Gout

Gouty Arthritis

Articular Gout

Gouty Arthropathy

Arthritis, Gouty

Arthritis Gouty

Idiopathic Gout

Idiopathic Gout, Unspecified Site

Gouty Bursitis

Uratic Arthritis

Gout Nos

Gouty

Gouty Diathesis
Acute Kidney Failure

Acute Renal Failure

Acute Kidney Injury

Renal Failure Acute

Kidney Failure, Acute

Pre-Renal Acute Kidney Injury

Nontraumatic Acute Kidney Injury

Aki - [Acute Kidney Injury]

Arf - [Acute Kidney Failure]

Acute Kidney Disease

Acute Kidney Impairment

Acute Ischaemic Renal Failure

Acute Hypoxic Kidney Failure

Acute Kidney Shutdown

Acute Renal Oedema

Acute Renal Impairment

Acute Kidney Collapse

Acute Necrotising Kidney

Acute Renal Suppression
Fanconi Syndrome

Infantile Nephropathic Cystinosis

Adult Fanconi Syndrome

Congenital Fanconi Syndrome

De Toni-Fanconi Syndrome

Fanconi-De Toni Syndrome

Lignac-Fanconi Syndrome

Fanconi Renotubular Syndrome

Primary Fanconi Renotubular Syndrome

De Toni-Debre-Fanconi Syndrome

Adult Fanconi Anemia

Detoni Fanconi Syndrome

Fanconi-De-Toni Syndrome

Primary Fanconi Syndrome

Detoni-Debre-Fanconi Syndrome

Primary Fanconi Renal Syndrome

Fanconi Anemia

Cystinosis, Infantile Nephropathic

Fanconi-Bickel Syndrome

Renal Fanconi Syndrome

Lowe-Bickel Syndrome
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS13078 SLC22A6 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus SLC22A6 RGD RGD:69338
Felis catus SLC22A6 VGNC VGNC:104330
Macaca mulatta SLC22A6 VGNC VGNC:77421
Canis familiaris SLC22A6 VGNC VGNC:46280
Mus musculus SLC22A6 MGD MGI:892001
Others SLC22A6 NCBI
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