2. Gene
  3. DHRS2 - dehydrogenase/reductase 2 Gene

DHRS2 - dehydrogenase/reductase 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：脱氢酶/还原酶 2

种属: Homo sapiens

同用名: HEP27; SDR25C1

基因 ID: 10202 | 基因类型: protein coding

关于 DHRS2

Cytogenetic location: 14q11.2 Genomic coordinates (GRCh38): 14:23,630,115-23,645,639 (from NCBI)

This gene has 10 transcripts (splice variants), 692 orthologues and 13 paralogues. Biased expression in urinary bladder (RPKM 75.6), salivary gland (RPKM 7.2) and 3 other tissues.

功能概要

该基因编码短链脱氢酶/还原酶 (SDR) 家族的成员，该家族拥有超过 46,000 名成员。这个家族的成员是代谢许多不同化合物的酶，例如类固醇激素、前列腺素、类维生素 A、脂质和异生素。替代启动子的使用和替代剪接会导致多种转录本变体。[RefSeq 提供，2017 年 2 月]

This gene encodes a member of the short-chain dehydrogenases/reductases (SDR) family, which has over 46,000 members. Members of this family are Enzymes that metabolize many different compounds, such as steroid Hormones, prostaglandins, retinoids, lipids and xenobiotics. Alternative promoter use and alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2017]

DHRS2 基因产物(3)

mRNA Protein Name
NM_001318835.1 NP_001305764.1 dehydrogenase/reductase SDR family member 2, mitochondrial isoform 3
NM_005794.4 NP_005785.1 dehydrogenase/reductase SDR family member 2, mitochondrial isoform 2
NM_182908.5 NP_878912.1 dehydrogenase/reductase SDR family member 2, mitochondrial isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables carbonyl reductase (NADPH) activity IDA
IDA: 通过直接分析推断
16685466 GOA
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IDA
IDA: 通过直接分析推断
16685466 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
25416956 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to oxidative stress IDA
IDA: 通过直接分析推断
19443906 GOA
involved in electron transport chain IDA
IDA: 通过直接分析推断
16685466 GOA
involved in myeloid dendritic cell differentiation IEP
IEP: 通过表达模式推断
11944995 GOA
involved in negative regulation of apoptotic process IMP
IMP: 通过突变表型推断
19443906 GOA
involved in response to toxic substance IDA
IDA: 通过直接分析推断
16685466 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
11944995 GOA
located in mitochondrion IDA
IDA: 通过直接分析推断
19443906 GOA
located in nuclear envelope IDA
IDA: 通过直接分析推断
11997086 GOA
located in nucleus IDA
IDA: 通过直接分析推断
1847869 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

DHRS2 蛋白结构

adh_short_C2

adh_short_C2: Enoyl-(Acyl carrier protein) reductase (45 - 273)

  • 0
  • 100
  • 200
  • 280 a.a.
蛋白主名 其他名称

dehydrogenase/reductase SDR family member 2, mitochondrial

dehydrogenase/reductase (SDR family) member 2

DHRS2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
DHRS2 Q13268 APPBP2 Homo sapiens Q92624
Y2H Prey Pooling
25416956
种属内
DHRS2 Q13268 APPBP2 Homo sapiens Q92624
Y2H Array
25416956
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Chronic Purulent Otitis Media

Chronic Suppurative Otitis Media

Csom - [Chronic Suppurative Otitis Media]
Middle Ear Disease

Middle Ear Anomaly

Disorder Of Middle Ear
Petrositis

Acute Petrositis

Chronic Petrositis

Inflammation Of Petrous Bone

Osteitis Of Petrous Bone

Osteomyelitis Of Petrous Bone
Suppurative Otitis Media

Otitis Media With Effusion - Purulent

Purulent Otitis Media

Otitis Media, Suppurative
Mastoiditis

Mastoiditis Nec
Otorrhea

Discharging Ear
Epiglottitis

Acute Epiglottitis

Acute Epiglottitis And Supraglottitis

Acute Epiglottiditis

Epiglottiditis

Epiglottitis Nos
Ulcerative Blepharitis
Salpingo-Oophoritis

Tubo-Ovarian Inflammatory Disease

Salpingitis/Oophoritis

Suppurative Salpingo Oophoritis

Tubo-Ovarian Inflammation

Tubo-Ovarian Inflammatory Disorder

Purulent Salpingo Oophoritis

Septic Salpingo Oophoritis

Salpingo-Ovaritis

Inflammation Oviduct

Ruptured Salpingo Oophoritis

Pyosalpinx Rupture
Auditory System Disease

Ear Diseases

Ear And Mastoid Disease
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (4)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-110100 CPYPP Inhibitor 99.94% 否
HY-124711 TBOPP Inhibitor 99.96% 否
HY-153128 DOCK2-IN-1 Inhibitor 96.20% 否
HY-RS03740 DHRS2 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta DHRS2 VGNC VGNC:84332
Canis familiaris DHRS2 VGNC VGNC:39933
Felis catus DHRS2 VGNC VGNC:80988
Rattus norvegicus DHRS2 RGD RGD:1583909
Mus musculus DHRS2 MGD MGI:1918662
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z