CLDN8 - claudin 8 Gene

中文名称：密蛋白 8

种属: Homo sapiens

同用名: HEL-S-79

基因 ID: 9073 | 基因类型: protein coding

关于 CLDN8

Cytogenetic location: 21q22.11 Genomic coordinates (GRCh38): 21:30,214,006-30,216,097 (from NCBI)

This gene has 1 transcript (splice variant), 222 orthologues and 22 paralogues.

功能概要

该基因编码密蛋白家族的一个成员。 Claudins 是完整的膜蛋白和紧密连接链的组成部分。紧密连接链作为物理屏障，防止溶质和水自由通过上皮或内皮细胞片之间的细胞旁空间，并且在维持细胞极性和信号转导中也起着关键作用。这种蛋白质在远端肾小管的细胞旁阳离子屏障和细胞旁屏障中起着重要作用，以防止远端结肠中的钠回漏。已在结直肠癌和肾细胞瘤中观察到该基因的差异表达，并与 claudin-7 一起成为鉴别诊断嫌色细胞肾细胞癌和肾嗜酸细胞瘤的免疫组织化学标记。[RefSeq 提供，2010 年 5 月]

This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This protein plays important roles in the paracellular cation barrier of the distal renal tubule, and in the paracellular barrier to prevent sodium back-leakage in distal colon. Differential expression of this gene has been observed in colorectal carcinoma and renal cell tumors, and along with claudin-7, is an immunohistochemical marker for the differential diagnosis of chromophobe renal cell carcinoma and renal oncocytoma.[provided by RefSeq, May 2010]

CLDN8 基因产物(1)

mRNA	Protein	Name
NM_199328.3	NP_955360.1	claudin-8

基因本体论

分子功能

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	25416956	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CLDN8 蛋白结构

PMP22_Claudin

0
100
200
225 a.a.

蛋白主名

其他名称

claudin-8

epididymis secretory protein Li 79

CLDN8 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	CLDN8	P56748	ARL13B	Homo sapiens	Q3SXY8	Y2H Array	32296183
种属内	CLDN8	P56748	ARL13B	Homo sapiens	Q3SXY8	Y2H Prey Pooling	32296183
种属内	CLDN8	P56748	ARL13B	Homo sapiens	Q3SXY8	Validated Y2H	32296183
种属内	CLDN8	P56748	TMEM80	Homo sapiens	Q96HE8	Y2H Array	32296183
种属内	CLDN8	P56748	TMEM80	Homo sapiens	Q96HE8	Y2H Prey Pooling	32296183
种属内	CLDN8	P56748	TMEM80	Homo sapiens	Q96HE8	Validated Y2H	32296183
种属内	CLDN8	P56748	CLEC17A	Homo sapiens	Q6ZS10	Validated Y2H	32296183
种属内	CLDN8	P56748	CLEC17A	Homo sapiens	Q6ZS10	Y2H Array	32296183
种属内	CLDN8	P56748	CLEC17A	Homo sapiens	Q6ZS10	Y2H Prey Pooling	32296183
种属内	CLDN8	P56748	PKMYT1	Homo sapiens	Q99640-2	Validated Y2H	32296183
种属内	CLDN8	P56748	OPRM1	Homo sapiens	P35372-10	Y2H Prey Pooling	32296183
种属内	CLDN8	P56748	OPRM1	Homo sapiens	P35372-10	Y2H Array	32296183
种属内	CLDN8	P56748	ADAM32	Homo sapiens	Q8TC27	Y2H Prey Pooling	32296183
种属内	CLDN8	P56748	ADAM32	Homo sapiens	Q8TC27	Validated Y2H	32296183
种属内	CLDN8	P56748	ADAM32	Homo sapiens	Q8TC27	Y2H Array	32296183
种属内	CLDN8	P56748	SYNE4	Homo sapiens	Q8N205	Y2H Array	25416956
种属内	CLDN8	P56748	SMIM3	Homo sapiens	Q9BZL3	Y2H Prey Pooling	32296183
种属内	CLDN8	P56748	SMIM3	Homo sapiens	Q9BZL3	Validated Y2H	32296183
种属内	CLDN8	P56748	SMIM3	Homo sapiens	Q9BZL3	Y2H Array	32296183
种属内	CLDN8	P56748	ERGIC3	Homo sapiens	Q9Y282	Y2H Prey Pooling	32296183
种属内	CLDN8	P56748	ERGIC3	Homo sapiens	Q9Y282	Validated Y2H	32296183
种属内	CLDN8	P56748	ERGIC3	Homo sapiens	Q9Y282	Y2H Array	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

CLDN8 抗体

目录号	产品名	应用	反应物种
HY-P81424	Claudin 8 Antibody (YA1169)	IHC-P	Human

关联疾病

疾病名称

别名

Renal Oncocytoma

Oncocytoma, Renal	Oncocytoma Of Kidney
Renal Epithelial Oncocytic Tumor	Oncocytoma Kidney
Oncocytoma Renal	Kidney Oncocytoma

Oncocytoma

Oxyphilic Adenoma	Follicular Adenoma, Oxyphilic Cell
Adenoma, Oxyphilic	Hurthle Cell Tumor
Oncocytic Neoplasm

Chromophobe Renal Cell Carcinoma

Chromophobe Adenocarcinoma	Chromophobe Carcinoma Of Kidney
Kidney Chromophobe	Renal Cell Carcinoma, Chromophobe Cell
Crcc	Chrcc
Chromophobe Renal Cell Adenocarcinoma	Chromophobe Renal Carcinoma
Chromophobe Carcinoma

Pseudohypoaldosteronism

Acute Salpingitis

Deafness, Autosomal Recessive 29

DFNB29	Autosomal Recessive Nonsyndromic Deafness 29
Autosomal Recessive Deafness 29	Deafness, Autosomal Recessive, 29
Non-Syndromic Neurosensory Deafness Autosomal Recessive Type 29	Non-Syndromic Sensorineural Deafness Autosomal Recessive Type 29
Deafness, Autosomal Recessive, Type 29

Renal Cell Carcinoma, Nonpapillary

Renal Cell Carcinoma	RCC
Nonpapillary Renal Cell Carcinoma	Clear Cell Renal Cell Carcinoma
Hypernephroma	Adenocarcinoma Of Kidney
Renal Carcinoma, Chromophobe, Somatic	Clear Cell Carcinoma Of Kidney
Clear-Cell Metastatic Renal Cell Carcinoma	Clear Cell Renal Carcinoma
Renal Cell Carcinoma, Somatic	Conventional Renal Cell Carcinoma
Conventional Renal Cell Carcinoma	Renal Clear Cell Carcinoma
Ccrcc	Hereditary Clear Cell Renal Cell Carcinoma
Carcinoma, Renal Cell	Renal Cell Carcinoma, Clear Cell, Somatic
Renal Cell Carcinoma, Clear Cell	Clear Cell Kidney Carcinoma
Clear Cell Rcc	Cystic-Multilocular Variant
Clear Cell Renal Cell Adenocarcinoma	Hereditary Clear Cell Renal Cell Adenocarcinoma
Common Renal Cell Carcinoma	Crcc
Renal Cell Carcinoma Non-Papillary	Carcinoma Renal Cell
Renal Cell Cancer	Carcinoma, Renal Cell, Nonpapillary

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS02776	CLDN8 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	CLDN8	MGD	MGI:1859286
Felis catus	CLDN8	VGNC	VGNC:102673
Macaca mulatta	CLDN8	VGNC	VGNC:81289
Bos taurus	CLDN8	VGNC	VGNC:27419
Rattus norvegicus	CLDN8	RGD	RGD:1308575
Canis familiaris	CLDN8	VGNC	VGNC:53023

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站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

CLDN8 - claudin 8 Gene

关于 CLDN8

功能概要

CLDN8 基因产物(1)

CLDN8 蛋白结构

CLDN8 蛋白互作信息

CLDN8 抗体

关联疾病

直系同源

热门区域

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CLDN8 - claudin 8 Gene

关于 CLDN8

功能概要

CLDN8 基因产物(1)

CLDN8 蛋白结构

CLDN8 蛋白互作信息

CLDN8 抗体

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z