RNF146 - ring finger protein 146 Gene

中文名称：无名指蛋白 146

种属: Homo sapiens

基因 ID: 81847 | 基因类型: protein coding

关于 RNF146

Cytogenetic location: 6q22.33 Genomic coordinates (GRCh38): 6:127,266,682-127,288,562 (from NCBI)

This gene has 13 transcripts (splice variants) and 276 orthologues. Ubiquitous expression in fat (RPKM 18.0), lung (RPKM 11.1) and 25 other tissues.

功能概要

启用聚-ADP-D-核糖结合活性和泛素蛋白转移酶活性。参与经典 Wnt 信号通路的正向调节；蛋白质泛素化；和泛素依赖性蛋白质分解代谢过程。位于胞质溶胶中；核质；和质膜。 [由基因组资源联盟提供，2022 年 4 月]

Enables poly-ADP-D-ribose binding activity and ubiquitin-protein transferase activity. Involved in positive regulation of canonical Wnt signaling pathway; protein ubiquitination; and ubiquitin-dependent protein catabolic process. Located in cytosol; nucleoplasm; and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

RNF146 基因产物(10)

mRNA	Protein	Name
NM_001242844.2	NP_001229773.1	E3 ubiquitin-protein ligase RNF146 isoform a
NM_001242845.2	NP_001229774.1	E3 ubiquitin-protein ligase RNF146 isoform a
NM_001242846.2	NP_001229775.1	E3 ubiquitin-protein ligase RNF146 isoform a
NM_001242847.2	NP_001229776.1	E3 ubiquitin-protein ligase RNF146 isoform a
NM_001242848.2	NP_001229777.1	E3 ubiquitin-protein ligase RNF146 isoform a
NM_001242849.2	NP_001229778.1	E3 ubiquitin-protein ligase RNF146 isoform b
NM_001242850.2	NP_001229779.1	E3 ubiquitin-protein ligase RNF146 isoform b
NM_001242851.1	NP_001229780.1	E3 ubiquitin-protein ligase RNF146 isoform b
NM_001242852.2	NP_001229781.1	E3 ubiquitin-protein ligase RNF146 isoform a
NM_030963.4	NP_112225.2	E3 ubiquitin-protein ligase RNF146 isoform a

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables poly-ADP-D-ribose binding	IDA IDA: 通过直接分析推断	21478859	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	21478859	GOA
enables ubiquitin-protein transferase activity	IDA IDA: 通过直接分析推断	21478859	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in positive regulation of canonical Wnt signaling pathway	IMP IMP: 通过突变表型推断	21478859	GOA
involved in protein K48-linked ubiquitination	IMP IMP: 通过突变表型推断	21478859	GOA
involved in protein autoubiquitination	IDA IDA: 通过直接分析推断	21478859	GOA
involved in ubiquitin-dependent protein catabolic process	IMP IMP: 通过突变表型推断	21478859	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cytosol	IDA IDA: 通过直接分析推断	15813938	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

RNF146 蛋白结构

zf-C3HC4

WWE

0
100
200
300
359 a.a.

蛋白主名

其他名称

E3 ubiquitin-protein ligase RNF146

RING-type E3 ubiquitin transferase RNF146

RNF146 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	RNF146	Q9NTX7	TUBGCP4	Homo sapiens	Q9UGJ1	Y2H Prey Pooling	25416956
Intra	RNF146	Q9NTX7	TUBGCP4	Homo sapiens	Q9UGJ1	Y2H Array	25416956
Intra	RNF146	Q9NTX7	TNKS	Homo sapiens	O95271	Pull Down	25327252
Intra	RNF146	Q9NTX7	TNKS	Homo sapiens	O95271	Anti Tag CoIP	21799911
Intra	RNF146	Q9NTX7	TNKS	Homo sapiens	O95271	Anti Tag CoIP	25327252
Intra	RNF146	Q9NTX7	TNKS	Homo sapiens	O95271	GMS	25327252
Intra	RNF146	Q9NTX7	TNKS	Homo sapiens	O95271	Light Scattering	25327252
Intra	RNF146	Q9NTX7	PARP1	Homo sapiens	P09874	Anti Tag CoIP	21799911
Intra	RNF146	Q9NTX7	PARP1	Homo sapiens	P09874	Pull Down	21799911
Intra	RNF146	Q9NTX7	TRAF2	Homo sapiens	Q12933	Y2H Prey Pooling	25416956
Intra	RNF146	Q9NTX7	TRAF2	Homo sapiens	Q12933	Validated Y2H	25416956
Intra	RNF146	Q9NTX7	KASH5	Homo sapiens	Q8N6L0	Validated Y2H	25416956

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Cherubism

CRBM	Familial Benign Giant-Cell Tumor Of The Jaw
Familial Fibrous Dysplasia Of Jaw	Familial Multilocular Cystic Disease Of The Jaws

Arthrogryposis, Renal Dysfunction, And Cholestasis 1

Arc Syndrome	ARCS1
Arthrogryposis Renal Dysfunction Cholestasis Syndrome	Arthrogryposis-Renal Dysfunction-Cholestasis Syndrome
Arcs	Arthrogryposis, Renal Dysfunction And Cholestasis Syndrome
Arthrogryposis, Renal Dysfunction, And Cholestasis	Arthrogryposis-Renal Dysfunction-Cholestasis
Arthrogryposis - Renal Dysfunction - Cholestasis	Arthrogryposis Multiplex Congenita, Renal Dysfunction, And Cholestasis
Arthrogryposis, Renal Dysfunction And Cholestasis Syndrome 1	Arthrogryposis Renal Dysfunction And Cholestasis 1
Arthrogryposis With Renal Dysfunction And Cholestasis Syndrome	Arthrogryposis, Renal Dysfunction, Cholestasis, Type 1
Kidney Failure	Renal Insufficiency

Alcohol-Related Birth Defects

Arbd	Alcohol-Related Birth Defect
Alcohol Related Birth Defect	Fetal Alcohol Syndrome

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-135782	iso-ADP ribose		/	否
HY-162175	TAMRA-isoADPr		/	否
HY-RS12056	RNF146 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	RNF146	RGD	RGD:1306482
Canis familiaris	RNF146	VGNC	VGNC:45638
Mus musculus	RNF146	MGD	MGI:1915281
Felis catus	RNF146	VGNC	VGNC:64675
Macaca mulatta	RNF146	VGNC	VGNC:76798
Others	RNF146	NCBI

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

RNF146 - ring finger protein 146 Gene

关于 RNF146

功能概要

RNF146 基因产物(10)

RNF146 蛋白结构

RNF146 蛋白互作信息

关联疾病

直系同源

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RNF146 - ring finger protein 146 Gene

关于 RNF146

功能概要

RNF146 基因产物(10)

RNF146 蛋白结构

RNF146 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z