TNKS - tankyrase Gene

中文名称：端锚聚合酶

种属: Homo sapiens

同用名: TIN1; ARTD5; PARPL; TINF1; TNKS1; pART5; PARP5A; PARP-5a

基因 ID: 8658 | 基因类型: protein coding

关于 TNKS

Cytogenetic location: 8p23.1 Genomic coordinates (GRCh38): 8:9,555,912-9,782,346 (from NCBI)

This gene has 13 transcripts (splice variants), 1 gene allele, 279 orthologues and 2 paralogues. Ubiquitous expression in testis (RPKM 8.6), brain (RPKM 7.0) and 25 other tissues.

功能概要

启用组蛋白结合活动；戊糖基转移酶活性；和锌离子结合活性。参与多个过程，包括维持有丝分裂姐妹染色单体内聚力、端粒的负调节；蛋白质 ADP-核糖基化；和调节含核碱基的化合物代谢过程。作用于肽基丝氨酸磷酸化的上游或内部；肽基-苏氨酸磷酸化；和蛋白质 ADP-核糖基化。位于多个细胞成分中，包括染色体、端粒区；有丝分裂纺锤体极；和核。 [由基因组资源联盟提供，2022 年 4 月]

Enables histone binding activity; pentosyltransferase activity; and zinc ion binding activity. Involved in several processes, including negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric; protein ADP-ribosylation; and regulation of nucleobase-containing compound metabolic process. Acts upstream of or within peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; and protein ADP-ribosylation. Located in several cellular components, including chromosome, telomeric region; mitotic spindle pole; and nucleus. [provided by Alliance of Genome Resources, Apr 2022]

TNKS 基因产物(3)

mRNA	Protein	Name
XM_011543846.4	XP_011542148.1	poly [ADP-ribose] polymerase tankyrase-1 isoform X2
NM_003747.3	NP_003738.2	poly [ADP-ribose] polymerase tankyrase-1
XM_011543845.4	XP_011542147.1	poly [ADP-ribose] polymerase tankyrase-1 isoform X1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables NAD+-protein ADP-ribosyltransferase activity	IDA IDA: 通过直接分析推断	9822378	GOA
enables NAD+-protein poly-ADP-ribosyltransferase activity	IDA IDA: 通过直接分析推断	9822378	GOA
enables histone binding	IPI IPI: 通过物理相互作用推断	26373281	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	9822378	GOA
enables zinc ion binding	IDA IDA: 通过直接分析推断	18436240	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric	IMP IMP: 通过突变表型推断	26373281	GOA
involved in negative regulation of telomere maintenance via telomere lengthening	IMP IMP: 通过突变表型推断	25939383	GOA
involved in negative regulation of telomeric DNA binding	IDA IDA: 通过直接分析推断	9822378	GOA
involved in negative regulation of telomeric DNA binding	IMP IMP: 通过突变表型推断	25939383	GOA
acts upstream of or within peptidyl-serine phosphorylation	IDA IDA: 通过直接分析推断	17026964	GOA
acts upstream of or within peptidyl-threonine phosphorylation	IDA IDA: 通过直接分析推断	17026964	GOA
involved in positive regulation of canonical Wnt signaling pathway	IMP IMP: 通过突变表型推断	19759537	GOA
involved in positive regulation of telomere capping	IMP IMP: 通过突变表型推断	25939383	GOA
involved in positive regulation of telomere maintenance via telomerase	IDA IDA: 通过直接分析推断	12782650	GOA
involved in positive regulation of telomere maintenance via telomerase	IMP IMP: 通过突变表型推断	11739745	GOA
involved in positive regulation of telomere maintenance via telomere lengthening	IDA IDA: 通过直接分析推断	12782650	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	19245366	GOA
involved in protein auto-ADP-ribosylation	IDA IDA: 通过直接分析推断	21478859	GOA
involved in protein localization to chromosome, telomeric region	IMP IMP: 通过突变表型推断	15133513	GOA
involved in protein poly-ADP-ribosylation	IDA IDA: 通过直接分析推断	9822378	GOA
involved in protein poly-ADP-ribosylation	IMP IMP: 通过突变表型推断	25939383	GOA
involved in protein polyubiquitination	IDA IDA: 通过直接分析推断	19759537	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in Golgi apparatus	IDA IDA: 通过直接分析推断	22864114	GOA
located in chromosome, telomeric region	IDA IDA: 通过直接分析推断	9822378	GOA
located in mitotic spindle pole	IDA IDA: 通过直接分析推断	16076287	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

TNKS 蛋白结构

Ank_2

Ank

Ank_2

Ank

Ank_2

Ank_4

Ank_2

Ank_4

SAM_2

PARP

0
300
600
900
1200
1327 a.a.

蛋白主名

其他名称

poly [ADP-ribose] polymerase tankyrase-1

ADP-ribosyltransferase diphtheria toxin-like 5	TANK1
TNKS-1	TRF1-interacting ankyrin-related ADP-ribose polymerase 1
poly [ADP-ribose] polymerase 5A	protein poly-ADP-ribosyltransferase tankyrase-1
tankyrase I	tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase
tankyrase-1

TNKS 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	TNKS	O95271	FNBP1	Homo sapiens	Q96RU3	Anti Tag CoIP	14596906
Intra	TNKS	O95271	FNBP1	Homo sapiens	Q96RU3	Y2H	14596906
Intra	TNKS	O95271	UBASH3B	Homo sapiens	Q8TF42	Validated Y2H	32296183
Intra	TNKS	O95271	TNKS1BP1	Homo sapiens	Q9C0C2	Pull Down	12080061
Cross	TNKS	O95271	Axin1	Mus musculus	O35625	Anti Tag CoIP	19759537
Intra	TNKS	O95271	DISC1	Homo sapiens	Q9NRI5	Y2H	17043677
Intra	TNKS	O95271	EPM2AIP1	Homo sapiens	Q7L775	Validated Y2H	32296183
Intra	TNKS	O95271	TERF1	Homo sapiens	P54274	Pull Down	12080061
Intra	TNKS	O95271	TERF1	Homo sapiens	P54274	Anti Tag CoIP	20696165
Intra	TNKS	O95271	ADPRS	Homo sapiens	Q9NX46	Validated Y2H	32296183
Intra	TNKS	O95271	HIF1AN	Homo sapiens	Q9NWT6	Enzymatic Study	21251231
Intra	TNKS	O95271	TCL1A	Homo sapiens	P56279	Validated Y2H	32296183
Intra	TNKS	O95271	OARD1	Homo sapiens	Q9Y530	Validated Y2H	32296183
Intra	TNKS	O95271	CENPJ	Homo sapiens	Q9HC77	Anti Tag CoIP	22699936
Intra	TNKS	O95271	CENPJ	Homo sapiens	Q9HC77	IF	22699936

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Chromosome 2q31.2 Deletion Syndrome

Cherubism

CRBM	Familial Benign Giant-Cell Tumor Of The Jaw
Familial Fibrous Dysplasia Of Jaw	Familial Multilocular Cystic Disease Of The Jaws

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

相关产品

Approval

生物活性分子 (1)

目录号	产品名	作用方式	纯度	是否罕见病
HY-108845	Tenecteplase		≥95.0%	否

Clinical Phase

生物活性分子 (2)

目录号	产品名	作用方式	纯度	Phase
HY-12418	Stenoparib	Inhibitor	≥98.0%	Phase 2
HY-147245	Basroparib	Inhibitor	98.49%	Phase 1

Pre-clinical Phase

生物活性分子 (50)

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-15147	XAV-939	Inhibitor	99.91%	否
HY-12438	G007-LK	Inhibitor	99.24%	否
HY-14443	XMD8-92	Inhibitor	99.67%	否
HY-13990	NVP-TNKS656		99.66%	否
HY-16910	WIKI4	Inhibitor	99.93%	否
HY-147316	TP-5801	Inhibitor	99.69%	否
HY-12975	AZ6102	Inhibitor	99.65%	否
HY-13968	JW 55	Inhibitor	98.95%	否
HY-15800A	CZC-25146	Inhibitor	99.10%	否
HY-19351	MN-64	Inhibitor	99.61%	否
HY-U00422	K-756	Inhibitor	99.25%	否
HY-145267	OM-153	Inhibitor	99.59%	否
HY-148063	DB0614		98.80%	否
HY-123851	MSC2504877	Inhibitor	98.50%	否
HY-15811	XMD8-87	Inhibitor	98.15%	否
HY-148061	DB1113		99.28%	否
HY-101243	XMD16-5	Inhibitor	98.59%	否
HY-143338	ART-IN-1	Inhibitor	98.91%	否
HY-147316A	TP-5801 TFA	Inhibitor	99.34%	否
HY-126248	Tankyrase-IN-2	Inhibitor	99.06%	否
HY-121719	TIQ-A	Inhibitor	99.65%	否
HY-147886	PARP1-IN-11	Inhibitor	98.58%	否
HY-148065	FMF-06-098-1		/	否
HY-137849	RK-582	Inhibitor	/	否
HY-100847	AZ0108	Inhibitor	/	否
HY-108516	TC-E 5001	Inhibitor	/	否
HY-117700	TNKS-IN-2	Inhibitor	/	否
HY-12577	TNKS1/2-IN-1		/	否
HY-12601	TNKS 22	Inhibitor	/	否
HY-145111	TNK2-IN-1	Inhibitor	/	否
HY-146336	PARP1/2/TNKS1/2-IN-1		/	否
HY-152197	Tankyrase-IN-3	Inhibitor	/	否
HY-152198	Tankyrase-IN-4	Inhibitor	/	否
HY-153259	TNKS1/2-IN-2	Inhibitor	/	否
HY-155246	PARP1-IN-15		/	否
HY-156332	TNKS-2-IN-2	Inhibitor	99.47%	否
HY-23338	TNKS-2-IN-1	Inhibitor	95.77%	否
HY-RS14837	TNK1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS14838	TNK2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS14839	TNKS Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS14840	Tnks Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS14841	Tnks Rat Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS14842	TNKS1BP1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS14843	TNKS2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS14844	Tnks2 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS14845	TNKS2 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-W294889	OUL245	Inhibitor	/	否
HY-118731	TNK-6123	Activator	/	否
HY-153332	Tankyrase-IN-5	Inhibitor	/	否
HY-15800	CZC-25146 hydrochloride	Inhibitor	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	TNKS	RGD	RGD:1308784
Felis catus	TNKS	VGNC	VGNC:66421
Mus musculus	TNKS	MGD	MGI:1341087
Canis familiaris	TNKS	VGNC	VGNC:47681
Macaca mulatta	TNKS	VGNC	VGNC:78601
Bos taurus	TNKS	VGNC	VGNC:36184
Others	TNKS	NCBI

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。	站点地图隐私声明
沪ICP备15051369号-4 上海工商沪公网安备31011502019417 沪(浦)应急管危经许[2021]201709(QFYS) 营业执照（三证合一）
Copyright © 2013-2024 MedChemExpress. All Rights Reserved.

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4