2. Cell Cycle/DNA Damage Epigenetics
  3. PARP
  4. OUL245

OUL245 是一种 7-羟基衍生物，是选择性的 PARP2 抑制剂 (IC50=44 nM)。OUL245 也抑制其他 PARP 和 TNKS 酶，IC50 为 2.9-8.8 μM。

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OUL245 Chemical Structure

OUL245 Chemical Structure

CAS No. : 1023814-45-0

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OUL245 相关抗体

Top Publications Citing Use of Products

查看 PARP 亚型特异性产品:

查看所有亚型
PARP PARP1 PARP2 PARP3 PARP4 TNKS1/PARP5A TNKS2/PARP5B PARP7 PARP10 PARP14 PARP15 PARP12 PARP16

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

OUL245 is a 7-Hydroxy derivative, and a selectively PARP2 inhibitor (IC50=44 nM). OUL245 also inhibits other PARP and TNKS enzymes with IC50s of 2.9-8.8 μM[1].

IC50 & Target[1]

PARP2

44 nM (IC50)

PARP-1

570 nM (IC50)

PARP3

8.8 μM (IC50)

PARP4

6.0 μM (IC50)

TNKS1

1.6 μM (IC50)

TNKS2

370 μM (IC50)

PARP10

2.9 μM (IC50)

PARP14

6.7 μM (IC50)

PARP15

2.0 μM (IC50)

体外研究
(In Vitro)

OUL245 (1 μM; 10-12 d) 与其他衍生物不同，它不能拯救过表达 PARP10 的细胞，使其免于 ADP 核糖化依赖的细胞死亡[1]。


药代动力学分析[1]

water solubility μg/mL GI Papp×10-6 cm/s (RM %) BBB Papp×10-6 cm/s (RM %) metabolic stablity % stab in human plasma stab. in MeOH stab in PBS pH 7.4
24.91 0.019 0.164 95.05 >24 >24 >24

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

OUL245 相关抗体:
分子量

191.21

Formula

C8H5N3OS
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

OUL245 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

OUL2451023814-45-0OUL 245OUL-245PARPpoly ADP ribose polymeraseInhibitorinhibitorinhibit

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产品名称：
OUL245
目录号：
HY-W294889
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