2. Gene
  3. ADPRS - ADP-ribosylserine hydrolase Gene

ADPRS - ADP-ribosylserine hydrolase Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：ADP-核糖丝氨酸水解酶

种属: Homo sapiens

同用名: ARH3; ADPRHL2; CONDSIAS

基因 ID: 54936 | 基因类型: protein coding

关于 ADPRS

Cytogenetic location: 1p34.3 Genomic coordinates (GRCh38): 1:36,088,892-36,093,932 (from NCBI)

This gene has 1 transcript (splice variant), 193 orthologues and is associated with 2 phenotypes. Ubiquitous expression in testis (RPKM 14.2), lung (RPKM 13.1) and 25 other tissues.

功能概要

该基因编码 ADP-核糖基糖水解酶家族的一个成员。编码的酶催化从 ADP 核糖基化蛋白质中去除 ADP 核糖。除了细胞核和细胞质外，这种酶还定位于线粒体。[RefSeq 提供，2009 年 2 月]

This gene encodes a member of the ADP-ribosylglycohydrolase family. The encoded Enzyme catalyzes the removal of ADP-ribose from ADP-ribosylated proteins. This Enzyme localizes to the mitochondria, in addition to the nucleus and cytoplasm.[provided by RefSeq, Feb 2009]

ADPRS 基因产物(1)

mRNA Protein Name
NM_017825.3 NP_060295.1 ADP-ribosylhydrolase ARH3
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables ADP-ribosylserine hydrolase activity IDA
IDA: 通过直接分析推断
28650317 GOA
enables O-acetyl-ADP-ribose deacetylase activity IDA
IDA: 通过直接分析推断
17075046 GOA
enables hydrolase activity, hydrolyzing O-glycosyl compounds IDA
IDA: 通过直接分析推断
30045870 GOA
enables magnesium ion binding IDA
IDA: 通过直接分析推断
30045870 GOA
enables poly(ADP-ribose) glycohydrolase activity IDA
IDA: 通过直接分析推断
17075046 GOA
enables poly(ADP-ribose) glycohydrolase activity IMP
IMP: 通过突变表型推断
33769608 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in DNA repair IMP
IMP: 通过突变表型推断
30045870 GOA
involved in cellular response to superoxide IMP
IMP: 通过突变表型推断
30401461 GOA
involved in peptidyl-serine ADP-deribosylation IDA
IDA: 通过直接分析推断
28650317 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
34479984 GOA
located in mitochondrion IDA
IDA: 通过直接分析推断
34479984 GOA
located in nucleus IDA
IDA: 通过直接分析推断
30045870 GOA
located in site of DNA damage IDA
IDA: 通过直接分析推断
30045870 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ADPRS 蛋白结构

ADP_ribosyl_GH

ADP_ribosyl_GH: ADP-ribosylglycohydrolase (25 - 339)

  • 0
  • 100
  • 200
  • 300
  • 363 a.a.
蛋白主名 其他名称

ADP-ribosylhydrolase ARH3

ADP-ribose glycohydrolase ARH3

ADPRS 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
ADPRS Q9NX46 TNKS Homo sapiens O95271
Y2H Array
32296183
种属内
ADPRS Q9NX46 TNKS Homo sapiens O95271
Y2H Prey Pooling
32296183
种属内
ADPRS Q9NX46 PRDM5 Homo sapiens Q9NQX1-2
Y2H Array
32296183
种属内
ADPRS Q9NX46 PRDM5 Homo sapiens Q9NQX1-2
Y2H Prey Pooling
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Neurodegeneration, Childhood-Onset, Stress-Induced, With Variable Ataxia And Seizures

CONDSIAS

Stress-Induced Childhood-Onset Neurodegeneration With Variable Ataxia And Seizures
Hypercholesterolemia, Familial, 4

Hypercholesterolemia, Autosomal Recessive

Arh

FHCL4

Autosomal Recessive Hypercholesterolemia

Arh1

Arh2

Autosomal Recessive Hypercholesterolemia 1

Autosomal Recessive Hypercholesterolemia 2

Fhcb1

Fhcb2

Hypercholesterolemia, Autosomal Recessive, 1, Formerly

Arh1, Formerly

Fhcb1, Formerly

Hypercholesterolemia, Autosomal Recessive, 2, Formerly

Arh2, Formerly

Fhcb2, Formerly

Familial Autosomal Recessive Hypercholesterolemia

Hypercholesterolemia, Familial, Autosomal Recessive

Hypercholesterolemia, Familial, Type 4
Arthrogryposis, Renal Dysfunction, And Cholestasis 1

Arc Syndrome

ARCS1

Arthrogryposis Renal Dysfunction Cholestasis Syndrome

Arthrogryposis-Renal Dysfunction-Cholestasis Syndrome

Arcs

Arthrogryposis, Renal Dysfunction And Cholestasis Syndrome

Arthrogryposis, Renal Dysfunction, And Cholestasis

Arthrogryposis-Renal Dysfunction-Cholestasis

Arthrogryposis - Renal Dysfunction - Cholestasis

Arthrogryposis Multiplex Congenita, Renal Dysfunction, And Cholestasis

Arthrogryposis, Renal Dysfunction And Cholestasis Syndrome 1

Arthrogryposis Renal Dysfunction And Cholestasis 1

Arthrogryposis With Renal Dysfunction And Cholestasis Syndrome

Arthrogryposis, Renal Dysfunction, Cholestasis, Type 1

Kidney Failure

Renal Insufficiency
Familial Hypercholesterolemia

Hyperlipoproteinemia Type Iia

Familial Hyperbetalipoproteinaemia

Familial Hypercholesteremia

Fredrickson Type Iia Hyperlipoproteinemia

Fredrickson Type Iia Lipidaemia

Hyperbetalipoproteinemia

Type Ii Hyperlipidemia

Familial Hypercholesterolæmia

Familial Hypercholesterolaemia

Fh

Hypercholesterolemia Familial

Hyperlipoproteinemia Type Ii

Hypercholesterolemia, Familial
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (11)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-150508 MK-0159 Inhibitor 99.72% 否
HY-146248B TFMU-ADPr diammonium 98.02% 否
HY-144987 RBN013209 Inhibitor 98.87% 否
HY-146248A TFMU-ADPr triethylamine 97.26% 否
HY-134261 8-Br-ADPR / 否
HY-134354 pNP-ADPr / 否
HY-134354A pNP-ADPr disodium 99.93% 否
HY-146248 TFMU-ADPr / 否
HY-RS00407 ADPRS Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-134268 8-Br-7-CH-ADPR Antagonist / 否
HY-137704 2′-Deoxy-ADPR Agonist / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus ADPRS MGD MGI:2140364
Macaca mulatta ADPRS VGNC VGNC:106317
Felis catus ADPRS VGNC VGNC:59652
Bos taurus ADPRS VGNC VGNC:25691
Rattus norvegicus ADPRS RGD RGD:1309068
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