2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. TRP Channel
  4. 8-Br-7-CH-ADPR

8-Br-7-CH-ADPR  (Synonyms: 8-Bromo-7-deazaadenosine-5'-O-diphosphoribose)

目录号: HY-134268
产品使用指南

摩尔计算器

8-Br-7-CH-ADPR (8-Bromo-7-deazaadenosine-5'-O-diphosphoribose) 是一种特异性的 TRPM2 拮抗剂，通过与 TRPM2 通道的 NUDT9 同源性结构域结合，抑制 TRPM2 的激活，从而控制阳离子通过细胞膜通道的流入。8-Br-7-CH-ADPR 可用于研究 TRPM2 在细胞死亡、神经退行性疾病、心肌梗死、糖尿病等病理过程中的作用。

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8-Br-7-CH-ADPR Chemical Structure

8-Br-7-CH-ADPR Chemical Structure

CAS No. : 1011457-95-6

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8-Br-7-CH-ADPR 相关抗体

Top Publications Citing Use of Products

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TRPC TRPM TRPV TRPA TRPML

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

8-Br-7-CH-ADPR (8-Bromo-7-deazaadenosine-5'-O-diphosphoribose) is a specific TRPM2 antagonist that inhibits TRPM2 activation by binding to the NUDT9 homology domain of the TRPM2 channel, thereby controlling the influx of cations through the cell membrane channel. 8-Br-7-CH-ADPR can be used to study the role of TRPM2 in pathological processes such as cell death, neurodegenerative diseases, myocardial infarction, and diabetes[1].

分子量

637.22

Formula

C16H23BrN4O14P2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

8-Br-7-CH-ADPR 相关分类

  • 摩尔计算器

  • 稀释计算器

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Keywords:

8-Br-7-CH-ADPR1011457-95-68-Bromo-7-deazaadenosine-5'-O-diphosphoriboseTRP ChannelTransient receptor potential channelsAntagonistsCation channelsNeurodegenerative diseasesMyocardial infarctionTRPM2Inhibitorinhibitorinhibit

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