2. Gene
  3. FNBP1 - formin binding protein 1 Gene

FNBP1 - formin binding protein 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：甲酸结合蛋白 1

种属: Homo sapiens

同用名: FBP17

基因 ID: 23048 | 基因类型: protein coding

关于 FNBP1

Cytogenetic location: 9q34.11 Genomic coordinates (GRCh38): 9:129,887,187-130,053,879 (from NCBI)

This gene has 13 transcripts (splice variants), 286 orthologues, 2 paralogues and is associated with 65 phenotypes. Ubiquitous expression in lymph node (RPKM 19.9), spleen (RPKM 17.6) and 24 other tissues.

功能概要

由该基因编码的蛋白质是甲酸结合蛋白家族的一员。该蛋白质包含一个 N 端 Fer/Cdc42 相互作用蛋白 4 (CIP4) 同源 (FCH) 结构域，然后是一个卷曲螺旋结构域、一个富含脯氨酸的基序、第二个卷曲螺旋结构域、一个 Rho 家族蛋白结合结构域 (RBD) ，以及一个 C 端 SH3 结构域。这种蛋白质结合分选连接蛋白 2 (SNX2) 、tankyrase (TNKS) 和发动蛋白；这种蛋白质和福尔明之间的相互作用尚未在人体中得到证实。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene is a member of the formin-binding-protein family. The protein contains an N-terminal Fer/Cdc42-interacting protein 4 (CIP4) homology (FCH) domain followed by a coiled-coil domain, a proline-rich motif, a second coiled-coil domain, a Rho family protein-binding domain (RBD), and a C-terminal SH3 domain. This protein binds sorting nexin 2 (SNX2), tankyrase (TNKS), and dynamin; an interaction between this protein and formin has not been demonstrated yet in human. [provided by RefSeq, Jul 2008]

FNBP1 基因产物(3)

mRNA Protein Name
NM_001363755.1 NP_001350684.1 formin-binding protein 1 isoform 2
NM_001411018.1 NP_001397947.1 formin-binding protein 1 isoform 3
NM_015033.3 NP_055848.1 formin-binding protein 1 isoform 1
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables identical protein binding IPI
IPI: 通过物理相互作用推断
15252009 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
11438682 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

FNBP1 蛋白结构

FCH

FCH: Fes/CIP4, and EFC/F-BAR homology domain (1 - 94)

SH3_9

SH3_9: Variant SH3 domain (557 - 607)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 617 a.a.
蛋白主名 其他名称

formin-binding protein 1

formin-binding protein 17

FNBP1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
FNBP1 Q96RU3 SNX2 Homo sapiens O60749
IF
14596906
种属内
FNBP1 Q96RU3 SNX2 Homo sapiens O60749
Anti Tag CoIP
11438682
种属内
FNBP1 Q96RU3 TNKS Homo sapiens O95271
Anti Bait CoIP
14596906
种属内
FNBP1 Q96RU3 TNKS Homo sapiens O95271
IF
14596906
种属内
FNBP1 Q96RU3 FNBP1 Homo sapiens Q96RU3
Solution Sedimentation
17512409
种属内
FNBP1 Q96RU3 FNBP1L Homo sapiens Q5T0N5
Anti Tag CoIP
35271311
种属内
FNBP1 Q96RU3 FNBP1 Homo sapiens Q96RU3
Anti Tag CoIP
15252009
种属内
FNBP1 Q96RU3 FASLG Homo sapiens P48023
Anti Tag CoIP
16318909
种属内
FNBP1 Q96RU3 DNM2 Homo sapiens P50570
Pull Down
15252009
种属内
FNBP1 Q96RU3 FNBP1 Homo sapiens Q96RU3
X-Ray Diffraction
17512409
种属内
FNBP1 Q96RU3 DNM1 Homo sapiens Q05193
Pull Down
15252009
种属内
FNBP1 Q96RU3 DNM1 Homo sapiens Q05193
Anti Tag CoIP
15252009
种属内
FNBP1 Q96RU3 FASLG Homo sapiens P48023
Anti Bait CoIP
16318909
种属内
FNBP1 Q96RU3 DNM2 Homo sapiens P50570
Fluorescence
15252009
种属内
FNBP1 Q96RU3 FASLG Homo sapiens P48023
Pull Down
16318909
种属内
FNBP1 Q96RU3 DNM3 Homo sapiens Q9UQ16
Fluorescence
15252009
种属内
FNBP1 Q96RU3 GABARAP Homo sapiens O95166
Pull Down
20562859
种属间
FNBP1 Q96RU3 Inpp5d Rattus norvegicus P97573
Pull Down
26751515
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Familial Hypocalciuric Hypercalcemia

Familial Benign Hypercalcemia

Fbh

Fbhh

Fhh

Familial Benign Hypocalciuric Hypercalcemia

Hypocalciuric Hypercalcemia, Familial, Type 1
Frank-Ter Haar Syndrome

Ter Haar Syndrome

Borrone Dermatocardioskeletal Syndrome

FTHS

Autosomal Recessive Melnick-Needles Syndrome

Borrone Di Rocco Crovato Syndrome

Megalocornea, Multiple Skeletal Anomalies, And Developmental Delay

Melnick-Needles Syndrome, Autosomal Recessive, Formerly

Frank Ter Haar Syndrome
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS05016 FNBP1 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS05017 FNBP1L Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus FNBP1 RGD RGD:621350
Felis catus FNBP1 VGNC VGNC:102927
Mus musculus FNBP1 MGD MGI:109606
Bos taurus FNBP1 VGNC VGNC:29059
Macaca mulatta FNBP1 VGNC VGNC:72520
Canis familiaris FNBP1 VGNC VGNC:40924
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z