2. Gene
  3. FNBP1L - formin binding protein 1 like Gene

FNBP1L - formin binding protein 1 like Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：甲酸结合蛋白 1

种属: Homo sapiens

同用名: TOCA1; C1orf39

基因 ID: 54874 | 基因类型: protein coding

关于 FNBP1L

Cytogenetic location: 1p22.1 Genomic coordinates (GRCh38): 1:93,448,118-93,554,661 (from NCBI)

This gene has 5 transcripts (splice variants), 211 orthologues and 2 paralogues. Ubiquitous expression in thyroid (RPKM 14.8), kidney (RPKM 13.9) and 24 other tissues.

功能概要

该基因编码的蛋白质与 CDC42 和 N-WASP 结合。这种蛋白质通过激活 N-WASP-WIP 复合物促进 CDC42 诱导的肌动蛋白聚合，因此参与将细胞表面信号与肌动蛋白细胞骨架联系起来的途径。可变剪接导致编码不同异构体的多个转录变体。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene binds to both CDC42 and N-WASP. This protein promotes CDC42-induced actin polymerization by activating the N-WASP-WIP complex and, therefore, is involved in a pathway that links cell surface signals to the actin Cytoskeleton. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

FNBP1L 基因产物(3)

mRNA Protein Name
NM_001024948.3 NP_001020119.1 formin-binding protein 1-like isoform 1
NM_001164473.3 NP_001157945.1 formin-binding protein 1-like isoform 3
NM_017737.5 NP_060207.2 formin-binding protein 1-like isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables GTPase binding IPI
IPI: 通过物理相互作用推断
19798448 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
16630611 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within cilium assembly IMP
IMP: 通过突变表型推断
22684256 GOA
involved in clathrin-dependent endocytosis IDA
IDA: 通过直接分析推断
20730103 GOA
involved in membrane invagination IDA
IDA: 通过直接分析推断
20730103 GOA
involved in plasma membrane tubulation IDA
IDA: 通过直接分析推断
20730103 GOA
involved in positive regulation of filopodium assembly IDA
IDA: 通过直接分析推断
20730103 GOA
involved in vesicle budding from membrane IDA
IDA: 通过直接分析推断
20730103 GOA
involved in vesicle organization IDA
IDA: 通过直接分析推断
20730103 GOA
involved in vesicle transport along actin filament IDA
IDA: 通过直接分析推断
20730103 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
22684256 GOA
located in cytoplasmic vesicle IDA
IDA: 通过直接分析推断
20730103 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

FNBP1L 蛋白结构

FCH

FCH: Fes/CIP4, and EFC/F-BAR homology domain (1 - 93)

SH3_1

SH3_1: SH3 domain (544 - 591)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 605 a.a.
蛋白主名 其他名称

formin-binding protein 1-like

toca-1

FNBP1L 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
FNBP1L Q5T0N5 FNBP1 Homo sapiens Q96RU3
Anti Tag CoIP
35271311
种属内
FNBP1L Q5T0N5 DAAM1 Homo sapiens Q9Y4D1
Anti Bait CoIP
16630611
种属内
FNBP1L Q5T0N5 DAAM1 Homo sapiens Q9Y4D1
Pull Down
16630611
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Alzheimer Disease 11

Ad11

Alzheimer'S Disease 11

Alzheimer Disease, Familial, 11

Alzheimer Disease-11

Alzheimer'S Disease 11, Late Onset
Malignant Breast Melanoma

Malignant Melanoma Of Breast

Breast Melanoma
Neutropenia, Severe Congenital, X-Linked

X-Linked Severe Congenital Neutropenia

XLN

SCNX

Severe Congenital Neutropenia X-Linked

Neutropenia, Congenital, Severe, X-Linked
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS05017 FNBP1L Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus FNBP1L MGD MGI:1925642
Canis familiaris FNBP1L VGNC VGNC:40925
Bos taurus FNBP1L VGNC VGNC:29060
Rattus norvegicus FNBP1L RGD RGD:1305386
Macaca mulatta FNBP1L VGNC VGNC:72543
Felis catus FNBP1L VGNC VGNC:62317
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