DAAM1 - dishevelled associated activator of morphogenesis 1 Gene

中文名称：形态发生紊乱相关激活因子 1

种属: Homo sapiens

基因 ID: 23002 | 基因类型: protein coding

关于 DAAM1

Cytogenetic location: 14q23.1 Genomic coordinates (GRCh38): 14:59,188,667-59,371,405 (from NCBI)

This gene has 13 transcripts (splice variants), 238 orthologues and 18 paralogues. Ubiquitous expression in skin (RPKM 17.9), esophagus (RPKM 12.9) and 25 other tissues.

功能概要

细胞运动、粘附、胞质分裂和细胞皮层的其他功能由肌动蛋白细胞骨架的重组介导，并且几种甲酸同源 (FH) 蛋白与这些过程相关。该基因编码的蛋白质包含两个 FH 结构域，属于与细胞极性有关的新型 FH 蛋白亚家族。细胞骨架结构的关键调节因子，小 GTPase Rho，在发育过程中被 Wnt/Fz 信号激活，以控制细胞极性和运动。由该基因编码的蛋白质被认为可作为 Wnt 诱导的蓬乱 (Dvl) -Rho 复合体组装的支架蛋白。这种蛋白质还促进新肌动蛋白丝的成核和伸长，并通过稳定微管来调节细胞生长。可变剪接导致编码不同蛋白质的多个转录变体。[RefSeq 提供，2012 年 7 月]

Cell motility, adhesion, cytokinesis, and Other functions of the cell cortex are mediated by reorganization of the actin Cytoskeleton and several formin homology (FH) proteins have been associated with these processes. The protein encoded by this gene contains two FH domains and belongs to a novel FH protein subfamily implicated in cell polarity. A key regulator of cytoskeletal architecture, the small GTPase Rho, is activated during development by Wnt/Fz signaling to control cell polarity and movement. The protein encoded by this gene is thought to function as a scaffolding protein for the Wnt-induced assembly of a disheveled (Dvl)-Rho complex. This protein also promotes the nucleation and elongation of new actin filaments and regulates cell growth through the stabilization of microtubules. Alternative splicing results in multiple transcript variants encoding distinct proteins. [provided by RefSeq, Jul 2012]

DAAM1 基因产物(2)

mRNA	Protein	Name
NM_001270520.2	NP_001257449.1	disheveled-associated activator of morphogenesis 1 isoform 2
NM_014992.2	NP_055807.1	disheveled-associated activator of morphogenesis 1 isoform 1

基因本体论

分子功能
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables identical protein binding	IPI IPI: 通过物理相互作用推断	16630611	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	16630611	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in ciliary basal body	IDA IDA: 通过直接分析推断	26644512	GOA
located in motile cilium	IDA IDA: 通过直接分析推断	26644512	GOA
located in stress fiber	IDA IDA: 通过直接分析推断	20534871	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

DAAM1 蛋白结构

Drf_GBD

Drf_FH3

FH2

0
200
400
600
800
1000
1078 a.a.

蛋白主名

其他名称

disheveled-associated activator of morphogenesis 1

DAAM1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	DAAM1	Q9Y4D1	INTU	Homo sapiens	Q9ULD6	Anti Tag CoIP	26644512
种属内	DAAM1	Q9Y4D1	DAAM1	Homo sapiens	Q9Y4D1	Pull Down	18218625
种属内	DAAM1	Q9Y4D1	RHOC	Homo sapiens	P08134	Pull Down	18218625
种属内	DAAM1	Q9Y4D1	RHOA	Homo sapiens	P61586	Anti Bait CoIP	18218625
种属内	DAAM1	Q9Y4D1	RHOA	Homo sapiens	P61586	Pull Down	18218625
种属内	DAAM1	Q9Y4D1	DAAM1	Homo sapiens	Q9Y4D1	Pull Down	16630611
种属内	DAAM1	Q9Y4D1	RHOA	Homo sapiens	P61586	PLA	25241761
种属内	DAAM1	Q9Y4D1	TRIP10	Homo sapiens	Q15642-2	Anti Tag CoIP	16630611
种属内	DAAM1	Q9Y4D1	TRIP10	Homo sapiens	Q15642-2	Pull Down	16630611
种属内	DAAM1	Q9Y4D1	RHOA	Homo sapiens	P61586	SPR	18218625
种属间	DAAM1	Q9Y4D1	SRC	Gallus gallus	P00523	Pull Down	16630611
种属间	DAAM1	Q9Y4D1	SRC	Gallus gallus	P00523	Anti Bait CoIP	16630611

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Cerebral Amyloid Angiopathy, Itm2b-Related, 2

Dementia, Familial Danish	Fdd
Familial Danish Dementia	Heredopathia Ophthalmootoencephalica
Hooe	Cerebellar Ataxia, Cataract, Deafness, And Dementia Or Psychosis
Adan Amyloidosis	Itm2b-Related Cerebral Amyloid Angiopathy 2
Itm2b Amyloidosis	Familial Cerebral Amyloid Angiopathy
Itm2b-Related Amyloidosis	Itm2b-Related Cerebral Amyloid Angiopathy
Familial Dementia, Danish Type	Cerebral Amyloid Angiopathy, Itm2b-Related 2
CAA-ITM2B2	Cerebellar Ataxia Cataract Deafness And Dementia Or Psychosis
Dementia, Familial, Danish

Gastric Tubular Adenocarcinoma

Tubular Adenocarcinoma Of Stomach

Double Outlet Right Ventricle

Double Outlet Right Ventricle With Subpulmonary Ventricular Septal Defect	Taussig-Bing Syndrome
Dextrotransposition Of Aorta	Taussig-Bing Syndrome Or Defect
Dorv	Dorv With Subpulmonary Vsd
Dorv-Tga	Double Outlet Right Ventricle With Transposition Of The Great Arteries
Double Outlet Right Ventricle With Subpulmonary Interventricular Communication, Transposition Type	Taussig-Bing Heart
Taussig-Bing Malformation	Taussig-Bing Complex
Taussig-Bing Defect	Taussig-Bing
Double Outlet Right Ventricle With Remote Ventricular Septal Defect	Double Outlet Right Ventricle With Uncommitted Ventricular Septal Defect
Double Outlet Right Ventricle With Non-Committed Interventricular Communication	Double Outlet Right Ventricle With Subaortic Or Doubly Committed Interventricular Communication Without Pulmonary Stenosis
Double Outlet Right Ventricle With Subaortic Or Doubly Committed Interventricular Communication And Pulmonary Stenosis

Neural Tube Defects

Spina Bifida	Neural Tube Defect
NTD	Neural Tube Defects, Susceptibility To
Spinal Dysraphism	Spina Bifida, Susceptibility To
Rachischisis	Cleft Spine
Open Spine	Hydrocele Spinalis
Neural Tube Defect Nos	Sb - [Spina Bifida]
Spinal Hernia Nos	Spinal Fissure Nos

Hepatocellular Carcinoma

Liver Cancer	Primary Liver Cancer
HCC	Hepatoma
Malignant Neoplasm Of Liver	Liver Neoplasms
Cancer, Hepatocellular	Liver Cell Carcinoma
Lcc	Hepatoblastoma, Somatic
Hepatic Cancer	Primary Malignant Neoplasm Of Liver
Rare Tumor Of Liver And Intrahepatic Biliary Tract	Hepatocellular Carcinoma, Somatic
Hepatocellular Carcinoma, Childhood Type, Somatic	Hepatocellular Cancer, Somatic
Ca Liver - Primary	Hepatic Neoplasm
Malignant Hepato-Biliary Neoplasm	Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary
Malignant Neoplasm Of Liver, Primary	Malignant Tumor Of Liver
Neoplasm Of Liver	Non-Resectable Primary Hepatic Malignant Neoplasm
Resectable Malignant Neoplasm Of Liver	Resectable Malignant Neoplasm Of The Liver
Primary Liver Carcinoma	Primary Malignant Liver Neoplasm
Primary Cancer Of Liver	Primary Tumor Of The Liver
Rare Tumor Of Liver And Ibt	Hepatocellular Cancer
Neoplasm Of The Liver	Carcinoma, Hepatocellular
Hepatomas	Liver Neoplasm
Liver Carcinoma	Liver And Intrahepatic Biliary Tract Carcinoma
Malignant Hepatobiliary Neoplasm	Adult Primary Hepatocellular Carcinoma
Hepatoblastoma	Carcinoma Of Liver
Malignant Liver Tumour	Malignant Hepatic Tumour

Strabismus

Strabismus, Susceptibility To	Strabismus, Susceptibility To, 1
Strabismus 1

Left Ventricular Noncompaction

Noncompaction Cardiomyopathy	Left Ventricular Hypertrabeculation
Lvnc	Spongy Myocardium
Isolated Noncompaction Of The Ventricular Myocardium	Left Ventricular Myocardial Noncompaction Cardiomyopathy
Fetal Myocardium	Honeycomb Myocardium
Hypertrabeculation Syndrome	Left Ventricular Non-Compaction
Lvht	Non-Compaction Of The Left Ventricular Myocardium
Ventricular Noncompaction, Left	Non-Compaction Cardiomyopathy

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS03508	DAAM1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Bos taurus	DAAM1	VGNC	VGNC:27862
Macaca mulatta	DAAM1	VGNC	VGNC:71657
Canis familiaris	DAAM1	VGNC	VGNC:39756
Mus musculus	DAAM1	MGD	MGI:1914596
Felis catus	DAAM1	VGNC	VGNC:61326
Rattus norvegicus	DAAM1	RGD	RGD:1305119

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

DAAM1 - dishevelled associated activator of morphogenesis 1 Gene

关于 DAAM1

功能概要

DAAM1 基因产物(2)

DAAM1 蛋白结构

DAAM1 蛋白互作信息

关联疾病

直系同源

热门区域

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DAAM1 - dishevelled associated activator of morphogenesis 1 Gene

关于 DAAM1

功能概要

DAAM1 基因产物(2)

DAAM1 蛋白结构

DAAM1 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z