1. Gene
  2. RHOC - ras homolog family member C Gene

RHOC - ras homolog family member C Gene

中文名称:ras 同系物家族成员 C

种属: Homo sapiens

同用名: H9; ARH9; ARHC; RHOH9

基因 ID: 389 | 基因类型: protein coding

关于 RHOC

Cytogenetic location: 1p13.2 Genomic coordinates (GRCh38): 1:112,701,131-112,707,408 (from NCBI)

This gene has 19 transcripts (splice variants), 257 orthologues and 22 paralogues. Ubiquitous expression in colon (RPKM 99.1), small intestine (RPKM 91.0) and 24 other tissues.

功能概要

该基因编码小 GTP 酶 Rho 家族的一个成员,它在非活性 GDP 结合状态和活性 GTP 结合状态之间循环,并在信号转导级联中充当分子开关。 Rho 蛋白促进肌动蛋白细胞骨架的重组并调节细胞形状、附着和运动。由该基因编码的蛋白质在其 C 末端被异戊二烯化,并定位于细胞质和质膜。它被认为在细胞运动中很重要。该基因的过度表达与肿瘤细胞增殖和转移有关。已经鉴定出编码相同蛋白质的多个可变剪接变体。[RefSeq 提供,2008 年 7 月]

This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin Cytoskeleton and regulate cell shape, attachment, and motility. The protein encoded by this gene is prenylated at its C-terminus, and localizes to the cytoplasm and plasma membrane. It is thought to be important in cell locomotion. Overexpression of this gene is associated with tumor cell proliferation and metastasis. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]

RHOC 基因产物(3)

mRNA Protein Name
NM_001042678.2 NP_001036143.1 rho-related GTP-binding protein RhoC precursor
NM_001042679.2 NP_001036144.1 rho-related GTP-binding protein RhoC precursor
NM_175744.5 NP_786886.1 rho-related GTP-binding protein RhoC precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
16189514 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in apical junction assembly IDA
IDA: 通过直接分析推断
20974804 GOA
involved in mitotic cytokinesis IDA
IDA: 通过直接分析推断
16236794 GOA
involved in positive regulation of cell migration IMP
IMP: 通过突变表型推断
20232393 GOA
involved in positive regulation of lipase activity IDA
IDA: 通过直接分析推断
19887681 GOA
involved in positive regulation of stress fiber assembly IMP
IMP: 通过突变表型推断
20232393 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cleavage furrow IDA
IDA: 通过直接分析推断
16236794 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

RHOC 蛋白结构

Ras

Ras: Ras family (7 - 177)

  • 0
  • 100
  • 193 a.a.
蛋白主名 其他名称

rho-related GTP-binding protein RhoC

RAS-related homolog 9

RHOC 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
RHOC P08134 RIPOR3 Homo sapiens Q96MK2
Validated Y2H
32296183
种属内
RHOC P08134 RIPOR2 Homo sapiens Q9Y4F9
Y2H Prey Pooling
25416956
种属内
RHOC P08134 DAAM1 Homo sapiens Q9Y4D1
Anti Tag CoIP
33961781
种属内
RHOC P08134 DIAPH1 Homo sapiens O60610
Pull Down
18218625
种属内
RHOC P08134 DIAPH1 Homo sapiens O60610
Anti Tag CoIP
33961781
种属内
RHOC P08134 ARHGAP1 Homo sapiens Q07960
Y2H Pooling
16189514
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Inflammatory Breast Carcinoma

Inflammatory Breast Cancer

Inflammatory Carcinoma Of Breast

Mastitis Carcinomatosa

Breast Cancer, Inflammatory

Inflammatory Breast Neoplasms

Inflammatory Adenocarcinoma Of Breast

Breast Disease

Breast Diseases

Hepatocellular Carcinoma

Liver Cancer

Primary Liver Cancer

HCC

Hepatoma

Malignant Neoplasm Of Liver

Liver Neoplasms

Cancer, Hepatocellular

Liver Cell Carcinoma

Lcc

Hepatoblastoma, Somatic

Hepatic Cancer

Primary Malignant Neoplasm Of Liver

Rare Tumor Of Liver And Intrahepatic Biliary Tract

Hepatocellular Carcinoma, Somatic

Hepatocellular Carcinoma, Childhood Type, Somatic

Hepatocellular Cancer, Somatic

Ca Liver - Primary

Hepatic Neoplasm

Malignant Hepato-Biliary Neoplasm

Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary

Malignant Neoplasm Of Liver, Primary

Malignant Tumor Of Liver

Neoplasm Of Liver

Non-Resectable Primary Hepatic Malignant Neoplasm

Resectable Malignant Neoplasm Of Liver

Resectable Malignant Neoplasm Of The Liver

Primary Liver Carcinoma

Primary Malignant Liver Neoplasm

Primary Cancer Of Liver

Primary Tumor Of The Liver

Rare Tumor Of Liver And Ibt

Hepatocellular Cancer

Neoplasm Of The Liver

Carcinoma, Hepatocellular

Hepatomas

Liver Neoplasm

Liver Carcinoma

Liver And Intrahepatic Biliary Tract Carcinoma

Malignant Hepatobiliary Neoplasm

Adult Primary Hepatocellular Carcinoma

Hepatoblastoma

Carcinoma Of Liver

Malignant Liver Tumour

Malignant Hepatic Tumour

Breast Cancer

Breast Carcinoma

Male Breast Cancer

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation

Glioblastoma

Glioblastoma Multiforme

Gbm

Adult Glioblastoma Multiforme

Grade Iv Adult Astrocytic Tumor

Primary Glioblastoma Multiforme

Spongioblastoma Multiforme

Adult Glioblastoma

Primary Glioblastoma

Prostate Cancer

Prostate Carcinoma

Prostate Cancer, Familial

Prostate Neoplasm

Prostate Cancer, Somatic

Prostate Cancer, Susceptibility To

Prostatic Cancer

Prostatic Neoplasms

Hereditary Prostate Cancer

Prostatic Neoplasm

Cancer Of Prostate

Carcinoma Of Prostate

Familial Prostate Cancer

Familial Prostate Carcinoma

Malignant Tumor Of Prostate

Malignant Neoplasm Of Prostate

Prostate Cancer, Familial, Susceptibility To

Malignant Tumor Of The Prostate

Ngp - New Growth Of Prostate

Tumor Of The Prostate

Prostate Cancer, Hereditary

Cancer Of The Prostate

Malignant Neoplasm Of The Prostate

Prostatic Carcinoma

PC

Prca

Cancer, Prostate

Malignant Prostatic Tumour

Malignant Tumour Of Prostate

Primary Prostate Cancer

Primary Malignant Neoplasm Of Prostate

Prostate Gland Cancer

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus RHOC RGD RGD:1304965
Mus musculus RHOC MGD MGI:106028
Bos taurus RHOC VGNC VGNC:55672