ARHGAP1 - Rho GTPase activating protein 1 Gene

中文名称：Rho GTP 酶激活蛋白 1

种属: Homo sapiens

同用名: RHOGAP; RHOGAP1; CDC42GAP; p50rhoGAP

基因 ID: 392 | 基因类型: protein coding

关于 ARHGAP1

Cytogenetic location: 11p11.2 Genomic coordinates (GRCh38): 11:46,677,080-46,700,619 (from NCBI)

This gene has 7 transcripts (splice variants), 166 orthologues and 1 paralogue. Ubiquitous expression in urinary bladder (RPKM 39.6), heart (RPKM 37.9) and 25 other tissues.

功能概要

该基因编码一大类蛋白质的成员，这些蛋白质可激活 Rho 型三磷酸鸟苷 (GTP) 代谢酶。编码的蛋白质包含一个 Src 同源 3 结构域，并与 Bcl-2 相关蛋白家族成员相互作用。[RefSeq 提供，2012 年 8 月]

This gene encodes a member of a large family of proteins that activate Rho-type guanosine triphosphate (GTP) metabolizing Enzymes. The encoded protein contains a Src homology 3 domain and interacts with Bcl-2-associated protein family members. [provided by RefSeq, Aug 2012]

ARHGAP1 基因产物(1)

mRNA	Protein	Name
NM_004308.5	NP_004299.1	rho GTPase-activating protein 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables GTPase activator activity	IDA IDA: 通过直接分析推断	8253717	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	9262406	GOA
enables small GTPase binding	IPI IPI: 通过物理相互作用推断	16380373	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in endosomal transport	IMP IMP: 通过突变表型推断	16380373	GOA
involved in negative regulation of endocytic recycling	IMP IMP: 通过突变表型推断	16380373	GOA
acts upstream of or within small GTPase-mediated signal transduction	IDA IDA: 通过直接分析推断	8253717	GOA
involved in transferrin transport	IMP IMP: 通过突变表型推断	16380373	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cytoplasm	IDA IDA: 通过直接分析推断	25468996	GOA
located in endosome membrane	IDA IDA: 通过直接分析推断	16380373	GOA
located in perinuclear region of cytoplasm	IDA IDA: 通过直接分析推断	16380373	GOA
colocalizes with sorting endosome	IMP IMP: 通过突变表型推断	16380373	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ARHGAP1 蛋白结构

CRAL_TRIO_2

RhoGAP

0
100
200
300
400
439 a.a.

蛋白主名

其他名称

rho GTPase-activating protein 1

CDC42 GTPase-activating protein

ARHGAP1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	ARHGAP1	Q07960	CDC42	Homo sapiens	P60953-2	X-Ray Diffraction	9846874
种属内	ARHGAP1	Q07960	CDC42	Homo sapiens	P60953-2	X-Ray Diffraction	9262406
种属内	ARHGAP1	Q07960	SH3GL1	Homo sapiens	Q99961	Validated Y2H	32296183
种属内	ARHGAP1	Q07960	RHOC	Homo sapiens	P08134	Anti Tag CoIP	35271311

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Nephrogenic Diabetes Insipidus

Vasopressin-Resistant Diabetes Insipidus	Diabetes Insipidus, Nephrogenic
Diabetes Insipidus Nephrogenic	Congenital Nephrogenic Diabetes Insipidus
Adh Resistant Diabetes Insipidus	Diabetes Insipidus Nephrogenic X-Linked
Diabetes Insipidus Nephrogenic Type 1	Adh-Resistant Diabetes Insipidus
Diabetes Insipidus Renalis	Ndi
Renal Diabetes Insipidus	Familial Nephrogenic Diabetes
Antidiuretic-Hormone-Resistant Diabetes Insipidus	Adiuretin-Resistant Diabetes Insipidus
Ndi - [Nephrogenic Diabetes Insipidus]	Diabetes Tenuifluus
Adh - [Antidiuretic-Hormone] Resistant Diabetes Insipidus	Hereditary Nephrogenic Diabetes Insipidus
Familial Nephrogenic Diabetes Insipidus	Primary Nephrogenic Diabetes Insipidus

Lowe Oculocerebrorenal Syndrome

Lowe Syndrome	Oculocerebrorenal Syndrome
OCRL	Oculocerebrorenal Syndrome Of Lowe
Ocrl1	Phosphatidylinositol 4,5-Bisphosphate 5-Phosphatase Deficiency
Lowe Disease	Phosphatidylinositol 4,5-Biphosphate 5-Phosphatase Deficiency
Cerebrooculorenal Syndrome	Phosphatidylinositol-4,5-Bisphosphate-5-Phosphatase Deficiency
Lowe Oculo-Cerebro-Renal Dystrophy	Lowe Oculo-Cerebro-Renal Syndrome
Lowe Oculocerebrorenal Dystrophy	Low
Chromosome 11p Deletion Syndrome	Oculocerebrorenal Dystrophy
Cerebro-Oculorenal Dystrophy	Ocrl1 - [Oculocerebrorenal Syndrome]
Lowe-Terrey-Maclachlan Syndrome	Renal-Oculocerebrodystrophy

Brain Cancer

Adult Brain Tumor	Malignant Neoplasm Of Brain
Brain Neoplasms	Brain Neoplasm
Neoplasm Of Brain	Primary Malignant Neoplasm Of Brain
Brain Tumors	Adult Malignant Brain Neoplasm
Brain Neoplasm, Adult	Bt - Brain Tumour
Malignant Brain Tumour	Malignant Primary Brain Neoplasm
Malignant Primary Brain Tumor	Malignant Tumor Of Adult Brain
Malignant Tumor Of Brain	Primary Brain Neoplasm
Primary Brain Tumor	Tumor Of The Brain
Brain Tumor, Adult	Brain Tumor Primary
Malignant Primary Brain Tumors	Primary Brain Tumors
Cancer, Brain	Brain Tumor, Primary

Microphthalmia

Microphthalmos	Isolated Anophthalmia-Microphthalmia Syndrome
Isolated Microphthalmia-Anophthalmia-Coloboma	Simple Microphthalmos
Clinical Anophthalmia	Isolated Anophthalmia - Microphthalmia
Isolated Pure Microphthalmia	Mac Spectrum
Microphthalmia-Anophthalmia-Coloboma Spectrum	Primitive Anophthalmia
Globe Of Eye Small	Small Eyeball
Hypoplasia Of Eye	Isolated Nanophthalmos
Rudimentary Eye	Dysplasia Of Eye

Non-Syndromic X-Linked Intellectual Disability

X-Linked Non-Syndromic Intellectual Disability	Non-Specific X-Linked Mental Retardation
X-Linked Non-Specific Intellectual Disability

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS00911	ARHGAP1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Felis catus	ARHGAP1	VGNC	VGNC:68110
Mus musculus	ARHGAP1	MGD	MGI:2445003
Macaca mulatta	ARHGAP1	VGNC	VGNC:70006
Canis familiaris	ARHGAP1	VGNC	VGNC:38044
Bos taurus	ARHGAP1	VGNC	VGNC:26073
Rattus norvegicus	ARHGAP1	RGD	RGD:1306068

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

ARHGAP1 - Rho GTPase activating protein 1 Gene

关于 ARHGAP1

功能概要

ARHGAP1 基因产物(1)

ARHGAP1 蛋白结构

ARHGAP1 蛋白互作信息

关联疾病

直系同源

热门区域

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ARHGAP1 - Rho GTPase activating protein 1 Gene

关于 ARHGAP1

功能概要

ARHGAP1 基因产物(1)

ARHGAP1 蛋白结构

ARHGAP1 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z