2. Cell Cycle/DNA Damage Epigenetics
  3. PARP
  4. TNKS1/2-IN-2

TNKS1/2-IN-2 (Compound 21) 是一种有效的选择性端锚聚合酶抑制剂。在酶测定中，TNKS1/2-IN-2 对 TNK1 和TNK2 的 IC50 值分别为 4 nM 和 63 nM。 TNKS1/2-IN-2 抑制 A549 和 H292 细胞系的增殖，IC50 值分别为 39.5 nM 和 12.8 nM。 TNKS1/2-IN-2 可用于癌症研究。

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TNKS1/2-IN-2 Chemical Structure

TNKS1/2-IN-2 Chemical Structure

CAS No. : 1498300-35-8

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TNKS1/2-IN-2 相关抗体

Top Publications Citing Use of Products

查看 PARP 亚型特异性产品:

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PARP PARP1 PARP2 PARP3 PARP4 TNKS1/PARP5A TNKS2/PARP5B PARP7 PARP10 PARP14 PARP15 PARP12 PARP16

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

TNKS1/2-IN-2 (Compound 21) is a potent and selective tankyrases inhibitor. TNKS1/2-IN-2 exhibits IC50 values of 4 nM and 63 nM against TNK1 and TNK2 in the enzymatic assay, respectively. TNKS1/2-IN-2 inhibits proliferation of A549 and H292 cell lines with IC50 values of 39.5 nM and 12.8 nM, respectively. TNKS1/2-IN-2 can be used for the research of cancer[1].
IC50 & Target

IC50: 4 nM (TNK1); 63 nM (TNK2); 39.5 nM (A549 cell); 12.8 nM (H292 cell)[1].
分子量

499.48

Formula

C26H24F3N3O4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

TNKS1/2-IN-2 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TNKS1/2-IN-21498300-35-8PARPpoly ADP ribose polymerasetankyrasesTNK1TNK2A549 cellH292 cellcancerInhibitorinhibitorinhibit

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