2. Gene
  3. FDPS - farnesyl diphosphate synthase Gene

FDPS - farnesyl diphosphate synthase Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：法尼基二磷酸合酶

种属: Homo sapiens

同用名: FPS; FPPS; POROK9

基因 ID: 2224 | 基因类型: protein coding

关于 FDPS

Cytogenetic location: 1q22 Genomic coordinates (GRCh38): 1:155,308,866-155,320,665 (from NCBI)

This gene has 21 transcripts (splice variants), 229 orthologues and is associated with 2 phenotypes. Ubiquitous expression in liver (RPKM 72.6), duodenum (RPKM 62.1) and 25 other tissues.

功能概要

该基因编码的酶可催化异戊烯焦磷酸和二甲基烯丙基焦磷酸生成香叶基焦磷酸和法尼基焦磷酸。所得产物法尼基焦磷酸是胆固醇和甾醇生物合成的关键中间体，是蛋白质法尼基化和香叶基香叶基化的底物，以及某些激素受体和生长受体的配体或激动剂。抑制这种酶的药物可防止小 GTP 酶的翻译后修饰，并已用于治疗与骨吸收相关的疾病。在 1、7、14、15、21 和 X 号染色体上发现了多个假基因。已经为该基因发现了编码不同亚型的多个转录变体。[RefSeq 提供，2008 年 10 月]

This gene encodes an Enzyme that catalyzes the production of geranyl pyrophosphate and farnesyl pyrophosphate from isopentenyl pyrophosphate and dimethylallyl pyrophosphate. The resulting product, farnesyl pyrophosphate, is a key intermediate in Cholesterol and sterol biosynthesis, a substrate for protein farnesylation and geranylgeranylation, and a ligand or agonist for certain hormone receptors and growth receptors. Drugs that inhibit this Enzyme prevent the post-translational modifications of small GTPases and have been used to treat diseases related to bone resorption. Multiple pseudogenes have been found on chromosomes 1, 7, 14, 15, 21 and X. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2008]

FDPS 基因产物(7)

mRNA Protein Name
NM_001135821.2 NP_001129293.1 farnesyl pyrophosphate synthase isoform a
NM_001135822.2 NP_001129294.1 farnesyl pyrophosphate synthase isoform b
NM_001242824.2 NP_001229753.1 farnesyl pyrophosphate synthase isoform b
NM_001242825.2 NP_001229754.1 farnesyl pyrophosphate synthase isoform c
NM_001378424.1 NP_001365353.1 farnesyl pyrophosphate synthase isoform b
NM_001378425.1 NP_001365354.1 farnesyl pyrophosphate synthase isoform b
NM_002004.4 NP_001995.1 farnesyl pyrophosphate synthase isoform a
基因本体论
  • 分子功能
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
16713569 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytosol IDA
IDA: 通过直接分析推断
17198737 GOA
located in mitochondrial matrix IDA
IDA: 通过直接分析推断
17198737 GOA
located in peroxisome IDA
IDA: 通过直接分析推断
17198737 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

FDPS 蛋白结构

polyprenyl_synt

polyprenyl_synt: Polyprenyl synthetase (111 - 380)

  • 0
  • 100
  • 200
  • 300
  • 419 a.a.
蛋白主名 其他名称

farnesyl pyrophosphate synthase

(2E,6E)-farnesyl diphosphate synthase

FDPS 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
FDPS P14324 SSMEM1 Homo sapiens Q8WWF3
Validated Y2H
32296183
种属内
FDPS P14324 SSMEM1 Homo sapiens Q8WWF3
Y2H Prey Pooling
32296183
种属内
FDPS P14324 SSMEM1 Homo sapiens Q8WWF3
Y2H Array
32296183
种属内
FDPS P14324 RNF19B Homo sapiens Q6ZMZ0
Y2H Prey Pooling
32296183
种属内
FDPS P14324 RNF19B Homo sapiens Q6ZMZ0
Validated Y2H
32296183
种属内
FDPS P14324 RNF19B Homo sapiens Q6ZMZ0
Y2H Array
32296183
种属内
FDPS P14324 ABHD16A Homo sapiens O95870
Y2H Prey Pooling
32296183
种属内
FDPS P14324 ABHD16A Homo sapiens O95870
Y2H Array
32296183
种属内
FDPS P14324 SLC30A2 Homo sapiens Q9BRI3
Validated Y2H
32296183
种属内
FDPS P14324 ATXN1 Homo sapiens P54253
Y2H Array
32814053
种属内
FDPS P14324 ATXN1 Homo sapiens P54253
Y2H Pooling
32814053
种属内
FDPS P14324 ATXN1 Homo sapiens P54253
Y2H
16713569
种属内
FDPS P14324 ATXN1 Homo sapiens P54253
Validated Y2H
32814053
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 FDPS 蛋白

目录号 产品名 蛋白编号 纯度
HY-P75197 FDPS Protein, Human (His) P14324-2/NP_001129294.1 (M1-K353) ≥95%

关联疾病

疾病名称 别名
Porokeratosis 9, Multiple Types

POROK9
Porokeratosis

Disseminated Superficial Actinic Porokeratosis

Dsap

Porokeratosis Of Mibelli

Porokeratosis, Disseminated Superficial Actinic

Porokeratosis, Disseminated Superficial Actinic, 1
Punctate Porokeratosis

Porokeratosis, Punctate

Keratoderma, Palmoplantar, Punctate Type Ii
Osteonecrosis

Bone Necrosis

Avascular Necrosis Of Bone

Aseptic Necrosis

Necrosis Of Bone Nos

Aseptic Osteonecrosis

Aseptic Necrosis Of Bone, Site Unspecified

Aseptic Or Avascular Bone Necrosis

Aseptic Necrosis Of Bone

Necrotic Bone

Necrotizing Bone

Spontaneous Osteonecrosis

Osteoradionecrosis
Linear Porokeratosis

Congenital Facial Linear Porokeratosis

Porokeratosis, Linear
Osteoporosis

Postmenopausal Osteoporosis

Osteoporosis, Postmenopausal

Bone Mineral Density Quantitative Trait Locus

Bmnd

Osteoporosis, Involutional

Osteoporosis, Susceptibility To

Osteoporosis, Postmenopausal, Susceptibility

Bone Mineral Density Variation Qtl, Osteoporosis

OSTEOP

Involutional Osteoporosis

Senile Osteoporosis

Osteoporosis Postmenopausal

Bone Mineral Density, Quantitative Trait Locus

Osteoporosis, Senile

Idiopathic Osteoporosis

Bone Rarefaction Nos

Type 1 Osteoporosis
Myasthenic Syndrome, Congenital, 2c, Associated With Acetylcholine Receptor Deficiency

Congenital Myasthenic Syndrome 2c

CMS2C

Congenital Myasthenic Syndrome 2c Associated With Acetylcholine Receptor Deficiency

Myasthenic Syndrome, Congenital, Type 2c, Associated With Acetylcholine Receptor Deficiency
Mammary Paget'S Disease

Paget'S Disease

Mammary Paget Disease

Paget'S Disease Of The Breast

Paget Disease Of The Breast

Paget'S Disease Of The Nipple

Paget'S Disease, Mammary

Paget Cell Neoplasm

Paget Disease Of The Nipple

Pagets Disease Mammary

Osteitis Deformans
Ischemic Bone Disease
Bone Disease

Bone Diseases

Skeletal Disease

Skeletal Disorder

Disorder Of Skeletal System
Glucocorticoid-Induced Osteoporosis

Steroid-Induced Osteoporosis
Breast Adenocarcinoma

Mammary Adenocarcinoma

Adenocarcinoma Of Breast
Paget'S Disease Of Bone

Osteitis Deformans

Paget Disease Of Bone

Osseous Paget'S Disease

Paget Disease Of Bone, Familial

Bone Paget Disease

Familial Paget'S Disease Of Bone

Paget'S Bone Disease

Familial Paget Disease Of Bone

Paget Disease, Bone

Pdb

Pagets Bone Disease
Bone Resorption Disease

Bone Resorption
Bone Remodeling Disease
Trypanosomiasis
Brittle Bone Disorder

Osteogenesis Imperfecta

Brittle Bone Disease

Fragilitas Ossium

Osteopsathyrosis

Lobstein Disease

Oi

Vrolik Disease

Lobstein'S Disease

Lobstein'S Syndrome

Vrolik'S Disease

Porak And Durante Disease

Glass Bone Disease

Osteogenesis Imperfecta, Dominant Perinatal Lethal

Osteogenesis Imperfecta, Recessive Perinatal Lethal

Brittle Bone Syndrome

Oi - [Osteogenesis Imperfecta]

Ossium Fragility

Osteitis Fragilitans

Bony Fragility

Blue Sclera With Fragility Of Bone And Deafness

White Blue Sclera - Fragility Of Bone - Deafness
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Approval
生物活性分子 (1)
目录号 产品名 作用方式
纯度 是否罕见病
HY-B0631 Alendronic acid Inhibitor ≥98.0% 是
Pre-clinical Phase
生物活性分子 (5)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-106950A Fosfructose trisodium ≥99.0% 否
HY-148077 Phosphoglycolohydroxamic acid Inhibitor ≥98.0% 否
HY-B0631S Alendronic acid-d6 ≥98.0% 否
HY-RS04853 FDPS Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-106950 Fosfructose / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus FDPS RGD RGD:68953
Mus musculus FDPS MGD MGI:104888
Macaca mulatta FDPS VGNC VGNC:106366
Canis familiaris FDPS VGNC VGNC:40812
Others FDPS NCBI
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