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  2. GPR161 - G protein-coupled receptor 161 Gene

GPR161 - G protein-coupled receptor 161 Gene

中文名称:G 蛋白偶联受体 161

种属: Homo sapiens

同用名: RE2

基因 ID: 23432 | 基因类型: protein coding

关于 GPR161

Cytogenetic location: 1q24.2 Genomic coordinates (GRCh38): 1:168,079,542-168,137,667 (from NCBI)

This gene has 11 transcripts (splice variants), 207 orthologues, 25 paralogues and is associated with 1 phenotype. Broad expression in endometrium (RPKM 8.0), esophagus (RPKM 3.6) and 20 other tissues.

功能概要

该基因编码的蛋白质是一种孤儿 G 蛋白偶联受体,其配体未知。该基因在三阴性乳腺癌中过度表达,破坏该基因会减缓基底乳腺癌细胞的增殖。因此,该基因是三阴性乳腺癌潜在的药物靶点。[RefSeq 提供,2017 年 3 月]

The protein encoded by this gene is an orphan G protein-coupled receptor whose ligand is unknown. This gene is overexpressed in triple-negative breast Cancer, and disruption of this gene slows the proliferation of basal breast Cancer cells. Therefore, this gene is a potential drug target for triple-negative breast Cancer. [provided by RefSeq, Mar 2017]

GPR161 基因产物(15)

mRNA Protein Name
NM_001267609.1 NP_001254538.1 G-protein coupled receptor 161 isoform 1
NM_001267610.2 NP_001254539.1 G-protein coupled receptor 161 isoform 2
NM_001267611.1 NP_001254540.1 G-protein coupled receptor 161 isoform 3
NM_001267612.2 NP_001254541.1 G-protein coupled receptor 161 isoform 4
NM_001267613.1 NP_001254542.1 G-protein coupled receptor 161 isoform 5
NM_001267614.1 NP_001254543.1 G-protein coupled receptor 161 isoform 6
NM_001349632.1 NP_001336561.1 G-protein coupled receptor 161 isoform 2
NM_001349633.1 NP_001336562.1 G-protein coupled receptor 161 isoform 2
NM_001349634.1 NP_001336563.1 G-protein coupled receptor 161 isoform 2
NM_001349635.1 NP_001336564.1 G-protein coupled receptor 161 isoform 4
NM_001375883.1 NP_001362812.1 G-protein coupled receptor 161 isoform 2
NM_001375884.1 NP_001362813.1 G-protein coupled receptor 161 isoform 2
NM_001375885.1 NP_001362814.1 G-protein coupled receptor 161 isoform 2
NM_001381909.1 NP_001368838.1 G-protein coupled receptor 161 isoform 2
NM_153832.3 NP_722561.1 G-protein coupled receptor 161 isoform 2
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

GPR161 蛋白结构

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (44 - 324)

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  • 500
  • 529 a.a.
蛋白主名 其他名称

G-protein coupled receptor 161

G-protein coupled receptor RE2

GPR161 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra GPR161 Q8N6U8 SLC30A2 Homo sapiens Q9BRI3
Validated Y2H
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Medulloblastoma

MDB

Cpnet

Localized Primitive Neuroectodermal Tumor

Classic Medulloblastoma

Medulloblastoma Predisposition Syndrome

Medulloblastoma, Somatic

Brain Medulloblastoma

Cns Pnet

Infratentorial Primitive Neuroectodermal Tumor

Neuroectodermal Tumors, Primitive

Medulloblastomas

Desmoplastic Medulloblastoma

Medulloblastoma, With Extensive Nodularity

Medulloblastoma Of Unspecified Site

Medullomyoblastoma Of Unspecified Site

Pituitary Stalk Interruption Syndrome

Ectopic Neurohypophysis

Psis

Pituitary Adenoma 2, Growth Hormone-Secreting

PITA2

Acromegaly Due To Pituitary Adenoma 2

Acromegaly, X-Linked

Growth Hormone Secreting Pituitary Adenoma 2

Pituitary Adenoma, Growth Hormone-Secreting, 2

Pituitary Adenoma 2, Gh-Secreting

Gh-Secreting Pituitary Adenoma 2

X-Linked Acromegaly

Adenoma, Pituitary, Growth Hormone-Secreting, Type 2

Alstrom Syndrome

ALMS

Alström Syndrome

Alss

Alstrom-Hallgren Syndrome

Alstroem Syndrome

Bardet-Biedl Syndrome

Bbs

Biedl-Bardet Syndrome

Joubert Syndrome 32

JBTS32

Joubert Syndrome 1

Joubert Syndrome

Jbts

Cerebellooculorenal Syndrome 1

JBTS1

Joubert-Boltshauser Syndrome

Cerebelloparenchymal Disorder Iv

Cpd4

Cors1

Joubert Syndrome And Related Disorders

Jsrd

Familial Aplasia Of The Vermis

Joubert Syndrome Related Disorders

Js

Cerebellar Vermis Agenesis

Cerebelloparenchymal Disorder 4

Agenesis Of Cerebellar Vermis

Cerebello-Oculo-Renal Syndrome

Cors

Joubert-Bolthauser Syndrome

Cpd Iv

Classic Joubert Syndrome

Joubert Syndrome Type A

Pure Joubert Syndrome

Cerebello-Oculo-Renal Syndrome 1

Joubert Syndrome-1

Joubert Syndrome, Type 1

Joubert'S Syndrome

Basal Cell Nevus Syndrome

Nevoid Basal Cell Carcinoma Syndrome

Gorlin Syndrome

Nbccs

BCNS

Gorlin-Goltz Syndrome

Multiple Basal Cell Nevi, Odontogenic Keratocysts, And Skeletal Anomalies

Cerebral Gigantism Jaw Cysts

Cramer Niederdellmann Syndrome

Gorlin Syndrome Or Gorlin-Goltz Syndrome

Naevoid Basal Cell Carcinoma Syndrome

Breast Cancer

Breast Carcinoma

Male Breast Cancer

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation

Ellis-Van Creveld Syndrome

Chondroectodermal Dysplasia

Mesoectodermal Dysplasia

EVC

Ellis Van Creveld Syndrome

Mesodermic Dysplasia

Ellis-Van Creveld Dysplasia

Meckel Syndrome, Type 1

Meckel-Gruber Syndrome

Meckel Syndrome

Dysencephalia Splanchnocystica

Meckel Syndrome 1

MKS1

Mks

Gruber Syndrome

Meckel-Gruber Syndrome, Type 1

Mes

Dysencephalia Splachnocystica

Meckel Gruber Syndrome

Meckel Syndrome Type 1

Nephronophthisis

Medullary Cystic Disease

Medullary Cystic Kidney

Nph

Nphp

Kidney Disease, Cystic, Medullary

Fundus Dystrophy

Retinal Dystrophy

Retinal Dystrophies

Dystrophy, Retinal

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta GPR161 VGNC VGNC:72991
Bos taurus GPR161 VGNC VGNC:29566
Canis familiaris GPR161 VGNC VGNC:41412
Rattus norvegicus GPR161 RGD RGD:1563245
Mus musculus GPR161 MGD MGI:2685054
Felis catus GPR161 VGNC VGNC:62684