FPR2 - formyl peptide receptor 2 Gene

中文名称：甲酰肽受体 2

种属: Homo sapiens

同用名: ALX; ALXR; HM63; FMLPX; FPR2A; FPRH1; FPRH2; FPRL1; LXA4R; FMLP-R-II

基因 ID: 2358 | 基因类型: protein coding

关于 FPR2

Cytogenetic location: 19q13.41 Genomic coordinates (GRCh38): 19:51,761,180-51,770,531 (from NCBI)

This gene has 6 transcripts (splice variants), 140 orthologues and 8 paralogues. Biased expression in appendix (RPKM 23.5), spleen (RPKM 4.6) and 5 other tissues.

功能概要

启用淀粉样蛋白-β 结合活性；清道夫受体结合活性；和信号受体活性。参与多个过程，包括对淀粉样蛋白-β 的细胞反应；单核细胞趋化性的正调节；和防御反应的调节。位于细胞质和质膜中。 [由基因组资源联盟提供，2022 年 4 月]

Enables amyloid-beta binding activity; scavenger receptor binding activity; and signaling receptor activity. Involved in several processes, including cellular response to amyloid-beta; positive regulation of monocyte chemotaxis; and regulation of defense response. Located in cytoplasm and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

FPR2 基因产物(2)

mRNA	Protein	Name
NM_001005738.2	NP_001005738.1	N-formyl peptide receptor 2
NM_001462.3	NP_001453.1	N-formyl peptide receptor 2

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables amyloid-beta binding	IPI IPI: 通过物理相互作用推断	11316806	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	15465011	GOA
enables scavenger receptor binding	IPI IPI: 通过物理相互作用推断	20141570	GOA
enables signaling receptor activity	IDA IDA: 通过直接分析推断	25505240	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in G protein-coupled receptor signaling pathway	IGI IGI: 通过遗传相互作用推断	11160457	GOA
involved in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	IGI IGI: 通过遗传相互作用推断	20141570	GOA
involved in calcium-mediated signaling	IGI IGI: 通过遗传相互作用推断	11160457	GOA
involved in cell surface receptor signaling pathway	IDA IDA: 通过直接分析推断	25505240	GOA
involved in cellular response to amyloid-beta	IDA IDA: 通过直接分析推断	11316806	GOA
involved in defense response to bacterium	IDA IDA: 通过直接分析推断	25505240	GOA
involved in immune response-regulating cell surface receptor signaling pathway	IDA IDA: 通过直接分析推断	25505240	GOA
involved in negative regulation of inflammatory response	IDA IDA: 通过直接分析推断	25505240	GOA
involved in positive regulation of ERK1 and ERK2 cascade	IGI IGI: 通过遗传相互作用推断	20141570	GOA
involved in positive regulation of ERK1 and ERK2 cascade	IMP IMP: 通过突变表型推断	20141570	GOA
involved in positive regulation of innate immune response	IDA IDA: 通过直接分析推断	25505240	GOA
involved in positive regulation of monocyte chemotaxis	IGI IGI: 通过遗传相互作用推断	11160457	GOA
involved in positive regulation of phagocytosis	IDA IDA: 通过直接分析推断	25505240	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cytoplasm	IDA IDA: 通过直接分析推断	11689470	GOA
located in plasma membrane	IDA IDA: 通过直接分析推断	11689470	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

FPR2 蛋白结构

7tm_1

0
100
200
300
351 a.a.

蛋白主名

其他名称

N-formyl peptide receptor 2

FMLP-R-I

FPR2 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	FPR2	P25090	LRRC25	Homo sapiens	Q8N386	Y2H Prey Pooling	32296183
种属内	FPR2	P25090	LRRC25	Homo sapiens	Q8N386	Validated Y2H	32296183
种属内	FPR2	P25090	LRRC25	Homo sapiens	Q8N386	Y2H Array	32296183
种属内	FPR2	P25090	SSMEM1	Homo sapiens	Q8WWF3	Validated Y2H	32296183
种属内	FPR2	P25090	SSMEM1	Homo sapiens	Q8WWF3	Y2H Prey Pooling	32296183
种属内	FPR2	P25090	SSMEM1	Homo sapiens	Q8WWF3	Y2H Array	32296183
种属内	FPR2	P25090	FXYD6	Homo sapiens	Q9H0Q3	Validated Y2H	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Diamond-Blackfan Anemia 2

DBA2	Anemia, Diamond-Blackfan, 2
Anemia Diamond-Blackfan 2

Prion Disease

Spongiform Encephalopathy	Transmissible Spongiform Encephalopathies
Prion Diseases	Prion Disease Pathway
Transmissible Spongiform Encephalopathy	Prion Induced Disorder
Prion Protein Disease	Inherited Human Transmissible Spongiform Encephalopathies
Prion Protein Diseases	Prion-Associated Disorders
Prion-Induced Disorders	Transmissible Dementias
Tses	Human Prion Disease
Tse	Encephalopathy, Transmissible Spongiform
Prion Disease, Susceptibility To	Spongiform Encephalopathies
Human Transmissible Spongiform Encephalopathies, Inherited

Severe Congenital Neutropenia 2

Scn2

Anaerobic Meningitis

Bacterial Infectious Disease

Bacterial Infections	Bacterial Infection Nos
Disease Caused By Bacteria	Bacterial Disease Or Disorder

Rheumatoid Arthritis

RA	Arthritis, Rheumatoid
Rheumatoid Arthritis, Susceptibility To	Arthritis Or Polyarthritis, Rheumatic
Atrophic Arthritis	Rheumatism Arthritis
Rheumatoid Polyarthritis

Alzheimer Disease, Familial, 1

Alzheimer Disease	Alzheimer'S Disease
Presenile And Senile Dementia	AD1
Alzheimer Disease, Susceptibility To	Alzheimer Disease, Late-Onset, Susceptibility To
Alzheimer Disease 1, Familial	AD
Familial Alzheimer Disease	Alzheimer Disease, Late-Onset
Alzheimers Dementia	Alzheimer Dementia
Alzheimer Sclerosis	Alzheimer Syndrome
Alzheimer-Type Dementia	Dat
Primary Senile Degenerative Dementia	Sdat
Alzheimer Disease 1	Autosomal Dominant Alzheimer Disease
Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy	Late Onset Alzheimer Disease
Alzheimers Disease	Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy
Late-Onset Alzheimers Disease	Alzheimer'S Disease Pathway Kegg
Dementia Due To Alzheimer'S Disease	Alzheimer Disease Type 1
Alzheimers

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

目录号	产品名	作用方式	纯度	Phase
HY-131180	BMS-986235		99.48%	Phase 1
HY-124071	ACT-389949		99.96%	Phase 1

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-P1120	WKYMVm		99.88%	否
HY-103286	PD176252	Antagonist	99.38%	否
HY-116216	PD 168368	Antagonist	≥99.0%	否
HY-19574	FPR Agonist 43		99.79%	否
HY-P1116A	PBP10 TFA	Inhibitor	98.14%	否
HY-155335	FPR2 agonist 3	Agonist	99.39%	否
HY-110246	Quin C1	Agonist	98.47%	否
HY-144604	FPR2 agonist 2	Agonist	99.59%	否
HY-P1117	MMK1		99.22%	否
HY-P1744	N-Formyl-Met-Leu-Phe-Lys		98.98%	否
HY-P1120A	WKYMVm TFA		/	否
HY-159583	FPR2 agonist 4	Agonist	/	否
HY-P10432	SHAAGtide	Activator	/	否
HY-P1116	PBP10	Inhibitor	/	否
HY-P1117A	MMK1 TFA		/	否
HY-RS05086	FPR2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	FPR2	MGD	MGI:1278319
Rattus norvegicus	FPR2	RGD	RGD:1584013
Macaca mulatta	FPR2	VGNC	VGNC:109506

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。	站点地图隐私声明
沪ICP备15051369号-4 上海工商沪公网安备31011502019417 沪(浦)应急管危经许[2021]201709(QFYS) 营业执照（三证合一）
Copyright © 2013-2025 MedChemExpress. All Rights Reserved.

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

FPR2 - formyl peptide receptor 2 Gene

关于 FPR2

功能概要

FPR2 基因产物(2)

FPR2 蛋白结构

FPR2 蛋白互作信息

关联疾病

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

姓名
邮箱 *

Sorry, but the email address you supplied was invalid.

FPR2 - formyl peptide receptor 2 Gene

关于 FPR2

功能概要

FPR2 基因产物(2)

FPR2 蛋白结构

FPR2 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z