MMK1 TFA 

MMK1 TFA is a potent and selective human formyl peptide receptor like-1 (FPRL-1/FPR2) agonist with EC₅₀s of <2 nM and >10000 nM for FPRL-1 and FPR1, respectively. MMK1 TFA is a potent chemotactic and calcium-mobilizing agonist. MMK1 TFA potently activates phagocytic leukocytes and enhances Pertussis Toxin-sensitive production by human monocytes of proinflammatory cytokines IL-1b and IL-6. MMK1 TFA exerts anxiolytic-like activity^[1][2][3][4].

MMK1 TFA 在人 FPRL1 转染的 HEK 293 (FPRL1/293) 细胞中诱导钙动员，EC₅₀ 为 2 nM^[1]。
MMK1 (1μM; 4 小时) TFA 诱导表达 FPR2 的 RBL-2H3 细胞的选择性迁移^[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

MMK1 (10-1000 pmol; 侧脑室注射; 测试前 20 分钟) TFA 以每只小鼠 100 pmol 的剂量发挥抗焦虑作用^[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

1610.96 (free acid)

C₇₅H₁₂₃N₁₉O₁₈S.xC₂HF₃O₂

Leu-Glu-Ser-Ile-Phe-Arg-Ser-Leu-Leu-Phe-Arg-Val-Met

LESIFRSLLFRVM

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. C Klein, et al. Identification of surrogate agonists for the human FPRL-1 receptor by autocrine selection in yeast. Nat Biotechnol. 1998 Dec;16(13):1334-7.  [Content Brief]

  [2]. Phuong Doan, et al. Alkylaminophenol and GPR17 Agonist for Glioblastoma Therapy: A Combinational Approach for Enhanced Cell Death Activity. Cells. 2021 Aug 3;10(8):1975.  [Content Brief]

  [3]. Yoo Jung Park, et al. A novel antimicrobial peptide acting via formyl peptide receptor 2 shows therapeutic effects against rheumatoid arthritis. Sci Rep. 2018 Oct 2;8(1):14664.  [Content Brief]

  [4]. Hui Zhao, et al. Rubimetide, humanin, and MMK1 exert anxiolytic-like activities via the formyl peptide receptor 2 in mice followed by the successive activation of DP1, A2A, and GABAA receptors. Peptides. 2016 Sep;83:16-20.  [Content Brief]