2. GPCR/G Protein Cell Cycle/DNA Damage Apoptosis
  3. Formyl Peptide Receptor (FPR) PERK Apoptosis
  4. WKYMVm

WKYMVm 是一种选择性地甲酰肽受体 2 (FPR2) 激动剂。WKYMVm 具有强大的抗炎作用，可减轻肺损伤和脊髓损伤。WKYMVm 能够通过调控脂质代谢和瘦素信号传导改善肥胖。WKYMVm 通过激活 FPRs 参与免疫细胞的调控，WKYMVm 能促进免疫细胞的趋化迁移，抑制吞噬细胞的凋亡 (apoptosis)。此外，WKYMVm 在肿瘤中可能发挥有利或不利的作用，这取决于肿瘤的类型。

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Custom Peptide Synthesis

WKYMVm Chemical Structure

WKYMVm Chemical Structure

CAS No. : 187986-17-0

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规格 价格 是否有货 数量
1 mg ￥1636
In-stock
5 mg ￥3600
In-stock
10 mg ￥5580
In-stock
50 mg   询价  
100 mg   询价  

* Please select Quantity before adding items.

Customer Review

Other Forms of WKYMVm:

WKYMVm 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

WKYMVm is a selective formylpeptide receptor 2 (FPR2) agonist. WKYMVm has a powerful anti-inflammatory effect that can reduce lung injury and spinal cord injury. WKYMVm ameliorates obesity by regulating lipid metabolism and leptin signaling. WKYMVm is involved in the regulation of immune cells by activating FPRs. WKYMVm can promote the chemotactic migration of immune cells and inhibit the apoptosis of phagocytes. In addition, WKYMVm may play a favorable or unfavorable role in tumors, depending on the type of tumor[1][2][3][4][5][6][7].

IC50 & Target

FPR1, FPRL1[1], FPRL2[2]
细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HL-60 EC50
0.001 μM
Compound: WKYMVm
Agonist activity at FPRL1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
Agonist activity at FPRL1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
[PMID: 19639995]
HL-60 EC50
0.01 μM
Compound: WKYMVm
Agonist activity at FPRL2 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
Agonist activity at FPRL2 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
[PMID: 19639995]
HL-60 EC50
0.5 μM
Compound: WKYMVm
Agonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
Agonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
[PMID: 19639995]
体外研究
(In Vitro)

WKYMVm (0-5 μmol/L；2 小时 ) 在 LPS (HY-D1056) 处理的小胶质细胞中抑制炎性细胞因子 (TNF-α, IL-6和 IL-1β) 的产生[3]。
WKYMVm (1-100 µM；0-24 小时) 在 HUVECs 细胞中可以增加 FPR2 mRNA 水平和 ERK 磷酸化水平，促进 HUVECs 管形成和细胞增殖[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

WKYMVm 相关抗体:
体内研究
(In Vivo)

WKYMVm (4 mg/kg；腹腔注射；3 次；间隔 24 h) 在大鼠脊髓损伤模型中具有保护作用[3]。
WKYMVm (2.5 mg/kg；腹腔注射；4 天) 可减轻新生小鼠高氧诱导的肺损伤[4]。
WKYMVm (8 mg/kg；皮下注射；两天一次；2-5 周) 可在高脂饲养的小鼠模型中改善肥胖[5]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Adult female Sprague-Dawley rats (200-220 g) with spinal cord injury[3]
Dosage: 4 mg/kg
Administration: Intraperitoneal injection (i.p.); 3 times with 24 hours intervals
Result: Reduce structural disorders and neuronal loss.
Reduced the phosphorylation of ERK1/2 and NF-κB p65 but not p38.
Animal Model: Normoxia or hyperoxic treated newborn mouse pups of C57/BL6[4]
Dosage: 2.5 mg/kg
Administration: Intraperitoneal injection (i.p.); daily from postnatal day (P) 5 to P8.
Result: Significantly attenuated hyperoxia-induced lung inflammation, as evidenced by increased inflammatory cytokines, neutrophils, and alveolar macrophages, and resultant lung injuries, which included impaired alveolarization and angiogenesis, an increased number of apoptotic cells, and reduced levels of growth factors in vivo, such as vascular endothelial growth factor and hepatocyte growth factor.
Animal Model: High fat diet treated male wild-type C57BL/6N mice aged 8 weeks old (21 ± 2 g)[5]
Dosage: 8 mg/kg
Administration: Subcutaneous injection (i.h.); once every 2 days; 2 or 5 weeks
Result: Significantly attenuated body weight gain, food intake and increased insulin sensitivity.
Markedly ameliorated HFD-induced hepatic steatosis and adipose tissue hypertrophy.
Improved lipid metabolism in adipose tissue.
Improved leptin signalling in the hypothalamus.
分子量

856.11

Formula

C41H61N9O7S2
CAS 号
性状

固体

颜色

White to off-white

Sequence

Trp-Lys-Tyr-Met-Val-{d-Met}-NH2
Sequence Shortening

WKYMV-{d-Met}-NH2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Sealed storage, away from moisture and light

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

溶解性数据
细胞实验： 

H2O 中的溶解度 : 12.5 mg/mL (14.60 mM; 超声助溶)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.1681 mL 5.8404 mL 11.6807 mL
5 mM 0.2336 mL 1.1681 mL 2.3361 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
您所需的储备液浓度超过该产品的实测溶解度，如有需要，请与 MCE 中国技术支持联系。
纯度 & 产品资料
参考文献

WKYMVm 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 1.1681 mL 5.8404 mL 11.6807 mL 29.2019 mL
5 mM 0.2336 mL 1.1681 mL 2.3361 mL 5.8404 mL
10 mM 0.1168 mL 0.5840 mL 1.1681 mL 2.9202 mL

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

WKYMVm187986-17-0Formyl Peptide Receptor (FPR)PERKApoptosisProtein kinase R-like endoplasmic reticulum kinasePKR-like endoplasmic reticulum kinaseMicrogliaHUVECsSpinal cord injury modelHigh-fat fed mouse modelFormyl Peptide Receptor AgonistInhibitorinhibitorinhibit

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目录号：
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