2. Gene
  3. TMEM9 - transmembrane protein 9 Gene

TMEM9 - transmembrane protein 9 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：跨膜蛋白 9

种属: Homo sapiens

同用名: DERM4; TMEM9A

基因 ID: 252839 | 基因类型: protein coding

关于 TMEM9

Cytogenetic location: 1q32.1 Genomic coordinates (GRCh38): 1:201,134,772-201,171,558 (from NCBI)

This gene has 11 transcripts (splice variants), 206 orthologues and 1 paralogue. Ubiquitous expression in brain (RPKM 25.4), thyroid (RPKM 25.3) and 25 other tissues.

功能概要

参与细胞内 pH 值降低；正向调控经典 Wnt 信号通路；和质子传输 V 型 ATPase 复合体组装。位于细胞器的界膜；细胞间桥；和有丝分裂纺锤体。 [由基因组资源联盟提供，2022 年 4 月]

Involved in intracellular pH reduction; positive regulation of canonical Wnt signaling pathway; and proton-transporting V-type ATPase complex assembly. Located in bounding membrane of organelle; intercellular bridge; and mitotic spindle. [provided by Alliance of Genome Resources, Apr 2022]

TMEM9 基因产物(9)

mRNA Protein Name
NM_001288564.2 NP_001275493.1 proton-transporting V-type ATPase complex assembly regulator TMEM9 isoform a precursor
NM_001288565.2 NP_001275494.1 proton-transporting V-type ATPase complex assembly regulator TMEM9 isoform a precursor
NM_001288566.2 NP_001275495.1 proton-transporting V-type ATPase complex assembly regulator TMEM9 isoform a precursor
NM_001288567.2 NP_001275496.1 proton-transporting V-type ATPase complex assembly regulator TMEM9 isoform a precursor
NM_001288568.2 NP_001275497.1 proton-transporting V-type ATPase complex assembly regulator TMEM9 isoform a precursor
NM_001288569.2 NP_001275498.1 proton-transporting V-type ATPase complex assembly regulator TMEM9 isoform a precursor
NM_001288570.2 NP_001275499.1 proton-transporting V-type ATPase complex assembly regulator TMEM9 isoform b precursor
NM_001288571.2 NP_001275500.1 proton-transporting V-type ATPase complex assembly regulator TMEM9 isoform c precursor
NM_016456.5 NP_057540.1 proton-transporting V-type ATPase complex assembly regulator TMEM9 isoform a precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
30374053 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in endosomal lumen acidification IDA
IDA: 通过直接分析推断
30374053 GOA
involved in lysosomal lumen acidification IDA
IDA: 通过直接分析推断
30374053 GOA
involved in positive regulation of canonical Wnt signaling pathway IDA
IDA: 通过直接分析推断
30374053 GOA
involved in proton-transporting V-type ATPase complex assembly IDA
IDA: 通过直接分析推断
30374053 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in late endosome IDA
IDA: 通过直接分析推断
12359240 GOA
located in lysosomal membrane IDA
IDA: 通过直接分析推断
30374053 GOA
located in lysosome IDA
IDA: 通过直接分析推断
12359240 GOA
located in multivesicular body membrane IDA
IDA: 通过直接分析推断
30374053 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

TMEM9 蛋白结构

Tmemb_9

Tmemb_9: TMEM9 (35 - 182)

  • 0
  • 100
  • 183 a.a.
蛋白主名 其他名称

proton-transporting V-type ATPase complex assembly regulator TMEM9

dermal papilla-derived protein 4

TMEM9 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra TMEM9 Q9P0T7 PGAP2 Homo sapiens Q9UHJ9-5
Validated Y2H
32296183
Intra TMEM9 Q9P0T7 STX6 Homo sapiens O43752
Anti Tag CoIP
33961781
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Snail Allergy
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS14746 TMEM9 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus TMEM9 RGD RGD:1307922
Mus musculus TMEM9 MGD MGI:1913491
Macaca mulatta TMEM9 VGNC VGNC:79162
Bos taurus TMEM9 VGNC VGNC:36125
Felis catus TMEM9 VGNC VGNC:66370
Others TMEM9 NCBI
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