BCAR1 - BCAR1 scaffold protein, Cas family member Gene

中文名称：BCAR1 支架蛋白，Cas 家族成员

种属: Homo sapiens

同用名: CAS; CAS1; CASS1; CRKAS; P130Cas

基因 ID: 9564 | 基因类型: protein coding

关于 BCAR1

Cytogenetic location: 16q23.1 Genomic coordinates (GRCh38): 16:75,228,181-75,268,007 (from NCBI)

This gene has 22 transcripts (splice variants), 1 gene allele, 201 orthologues and 3 paralogues. Broad expression in spleen (RPKM 6.5), kidney (RPKM 6.3) and 24 other tissues.

功能概要

由该基因编码的蛋白质是支架蛋白 Crk 相关底物 (CAS) 家族的成员，其特征是存在多个蛋白质-蛋白质相互作用结构域以及许多丝氨酸和酪氨酸磷酸化位点。编码的蛋白质包含一个 Src 同源 3 (SH3) 结构域、一个富含脯氨酸的结构域、一个底物结构域，其中包含 Src 家族激酶的 YxxP 共有磷酸化基序的 15 个重复、一个富含丝氨酸的结构域和一个二分体 Src 结合域，它可以绑定 SH2 和 SH3 域。这种衔接蛋白在多种细胞通路中发挥作用，包括细胞运动、细胞凋亡和细胞周期控制。该基因的失调会产生广泛的影响，影响不同的途径，包括心脏发育、血管平滑肌细胞、肝肾功能、内皮细胞迁移和癌症。[RefSeq 提供，2017 年 9 月]

The protein encoded by this gene is a member of the Crk-associated substrate (CAS) family of scaffold proteins, characterized by the presence of multiple protein-protein interaction domains and many serine and tyrosine phosphorylation sites. The encoded protein contains a Src-homology 3 (SH3) domain, a proline-rich domain, a substrate domain which contains 15 repeat of the YxxP consensus phosphorylation motif for Src family kinases, a serine-rich domain, and a bipartite Src-binding domain, which can bind both SH2 and SH3 domains. This adaptor protein functions in multiple cellular pathways, including in cell motility, Apoptosis and cell cycle control. Dysregulation of this gene can have a wide range of effects, affecting different pathways, including cardiac development, vascular smooth muscle cells, liver and kidney function, endothelial migration, and Cancer. [provided by RefSeq, Sep 2017]

BCAR1 基因产物(9)

mRNA	Protein	Name
NM_001170714.3	NP_001164185.1	breast cancer anti-estrogen resistance protein 1 isoform 1
NM_001170715.3	NP_001164186.1	breast cancer anti-estrogen resistance protein 1 isoform 2
NM_001170716.3	NP_001164187.1	breast cancer anti-estrogen resistance protein 1 isoform 3
NM_001170717.3	NP_001164188.1	breast cancer anti-estrogen resistance protein 1 isoform 4
NM_001170718.3	NP_001164189.1	breast cancer anti-estrogen resistance protein 1 isoform 5
NM_001170719.3	NP_001164190.1	breast cancer anti-estrogen resistance protein 1 isoform 7
NM_001170720.3	NP_001164191.1	breast cancer anti-estrogen resistance protein 1 isoform 8
NM_001170721.3	NP_001164192.1	breast cancer anti-estrogen resistance protein 1 isoform 9
NM_014567.5	NP_055382.2	breast cancer anti-estrogen resistance protein 1 isoform 6

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	9285683	GOA
enables protein kinase binding	IPI IPI: 通过物理相互作用推断	8070403	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in B cell receptor signaling pathway	IDA IDA: 通过直接分析推断	9020138	GOA
involved in actin filament organization	IDA IDA: 通过直接分析推断	16105984	GOA
involved in antigen receptor-mediated signaling pathway	IDA IDA: 通过直接分析推断	10587647	GOA
involved in cell chemotaxis	IMP IMP: 通过突变表型推断	21245381	GOA
involved in cell migration	IDA IDA: 通过直接分析推断	9425168	GOA
involved in cellular response to hepatocyte growth factor stimulus	IMP IMP: 通过突变表型推断	21245381	GOA
involved in endothelin receptor signaling pathway	IDA IDA: 通过直接分析推断	19086031	GOA
involved in hepatocyte growth factor receptor signaling pathway	IMP IMP: 通过突变表型推断	21245381	GOA
involved in integrin-mediated signaling pathway	IDA IDA: 通过直接分析推断	8649368	GOA
involved in positive regulation of cell migration	IDA IDA: 通过直接分析推断	9472046	GOA
involved in positive regulation of endothelial cell migration	IDA IDA: 通过直接分析推断	21245381	GOA
involved in vascular endothelial growth factor receptor signaling pathway	IMP IMP: 通过突变表型推断	21245381	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cytoplasm	IDA IDA: 通过直接分析推断	8070403	GOA
located in focal adhesion	IDA IDA: 通过直接分析推断	21245381	GOA
colocalizes with plasma membrane	IDA IDA: 通过直接分析推断	21245381	GOA
located in ruffle	IDA IDA: 通过直接分析推断	9472046	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

BCAR1 蛋白结构

SH3_1

Serine_rich

DUF3513

0
200
400
600
800
870 a.a.

蛋白主名

其他名称

breast cancer anti-estrogen resistance protein 1

BCAR1, Cas family scaffold protein

BCAR1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	BCAR1	P56945	ANKS1A	Homo sapiens	Q49AR9	Validated Y2H	32296183
种属内	BCAR1	P56945	EEIG1	Homo sapiens	Q5T9C2-3	Validated Y2H	32296183
种属内	BCAR1	P56945	TNS3	Homo sapiens	Q68CZ2	Pull Down	19732724
种属内	BCAR1	P56945	TNS3	Homo sapiens	Q68CZ2	IF	19732724
种属内	BCAR1	P56945	INPPL1	Homo sapiens	O15357	Anti Bait CoIP	11158326
种属内	BCAR1	P56945	SRCIN1	Homo sapiens	Q9C0H9	Anti Bait CoIP	14657239
种属内	BCAR1	P56945	BCAR3	Homo sapiens	O75815-1	ITC	22081014
种属内	BCAR1	P56945	BCAR3	Homo sapiens	O75815-1	GMS	22081014
种属内	BCAR1	P56945	BCAR3	Homo sapiens	O75815-1	Anti Bait CoIP	22081014
种属内	BCAR1	P56945	PTPN12	Homo sapiens	Q05209	Affinity Chrom	9285683
种属内	BCAR1	P56945	PRAM1	Homo sapiens	Q96QH2	Validated Y2H	32296183
种属内	BCAR1	P56945	IQGAP1	Homo sapiens	P46940	Anti Bait CoIP	28007913
种属内	BCAR1	P56945	FYN	Homo sapiens	P06241	Pull Down	9360983
种属内	BCAR1	P56945	TNK2	Homo sapiens	Q07912	Pull Down	17038317
种属内	BCAR1	P56945	TNK2	Homo sapiens	Q07912	Anti Bait CoIP	17038317
种属内	BCAR1	P56945	SRC	Homo sapiens	P12931	Pull Down	17038317
种属内	BCAR1	P56945	SRC	Homo sapiens	P12931	CoIP	21034468
种属内	BCAR1	P56945	SRC	Homo sapiens	P12931	Fluorescence	10542110
种属内	BCAR1	P56945	FAM90A1	Homo sapiens	Q86YD7	Validated Y2H	32296183
种属内	BCAR1	P56945	GLIS2	Homo sapiens	Q9BZE0	Validated Y2H	32296183
种属内	BCAR1	P56945	SH2D3C	Homo sapiens	Q8N5H7	Anti Tag CoIP	33961781
种属间	BCAR1	P56945	Srcin1	Mus musculus	Q9QWI6	Anti Bait CoIP	14657239
种属内	BCAR1	P56945	CRK	Homo sapiens	P46108	Anti Bait CoIP	14657239
种属内	BCAR1	P56945	CRK	Homo sapiens	P46108	Pull Down	17038317
种属内	BCAR1	P56945	PTPN1	Homo sapiens	P18031	Anti Bait CoIP	9407132
种属内	BCAR1	P56945	PTPN1	Homo sapiens	P18031	Filter Binding	9418872
种属内	BCAR1	P56945	PTPN1	Homo sapiens	P18031	Phosphatase Assay	10889023
种属内	BCAR1	P56945	MMP14	Homo sapiens	P50281	Anti Bait CoIP	18164686

种属间: 跨种属相互作用 种属内: 同种属相互作用

BCAR1 抗体

目录号	产品名	应用	反应物种
HY-P82815	BCAR1 Antibody (YA2560)	WB	Human, Mouse, Rat

关联疾病

疾病名称

别名

Estrogen Resistance

Estrogen Resistance Syndrome	ESTRR
Estrogen Insensitivity

Cystic Kidney Disease

Renal Cyst	Simple Renal Cyst
Kidney Cysts	Kidney Diseases, Cystic
Renal Cysts	Kidney Cyst
Cystic Kidney	Congenital Cystic Kidney Disease
Cystic Kidney Diseases	Bosniak 1 Cyst

Nephronophthisis 1

NPHP1	Nephronophthisis, Familial Juvenile
Nph1	Nephronophthisis 1, Juvenile
Juvenile Nephronophthisis 1	Familial Juvenile Nephronophthisis 1
Nephronophthisis, Type 1

Hereditary Breast Ovarian Cancer Syndrome

Hereditary Breast And Ovarian Cancer Syndrome	Brca1- And Brca2-Associated Hereditary Breast And Ovarian Cancer
Breast And/Or Ovarian Cancer	Breast And Ovarian Cancer Syndrome
Hboc Syndrome	Hereditary Breast And Ovarian Cancer
Brca1- Brca2-Associated Hboc

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Pancreatic Cancer

Pancreatic Carcinoma	Carcinoma Of Pancreas
Familial Pancreatic Carcinoma	Pancreatic Neoplasm
Pancreatic Carcinoma, Familial	Malignant Neoplasm Of Pancreas
Pancreatic Acinar Carcinoma	Pancreatic Tumor
Familial Pancreatic Cancer	Neoplasm Of The Pancreas
Cancer Of The Pancreas	Pancreatic Carcinoma, Somatic
Pancreatic Cancer, Somatic	Ca Body Of Pancreas
Ca Head Of Pancreas	Ca Tail Of Pancreas
Malignant Neoplasm Of Body Of Pancreas	Malignant Neoplasm Of Head Of Pancreas
Malignant Neoplasm Of Tail Of Pancreas	Pancreas Neoplasm
Exocrine Cancer	Exocrine Pancreas Carcinoma
Hereditary Pancreatic Cancer	Hereditary Pancreatic Carcinoma
PNCA	Pancreatic Cancer, Susceptibility To
Carcinoma Of Head Of Pancreas	Pancreatic Neoplasms
Pancreatic Tumors	Cancer, Pancreatic
Cancer Of Pancreas	Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site

Nephronophthisis

Medullary Cystic Disease	Medullary Cystic Kidney
Nph	Nphp
Kidney Disease, Cystic, Medullary

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS01397	BCAR1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Canis familiaris	BCAR1	VGNC	VGNC:38398
Felis catus	BCAR1	VGNC	VGNC:69188
Mus musculus	BCAR1	MGD	MGI:108091
Macaca mulatta	BCAR1	VGNC	VGNC:70234
Rattus norvegicus	BCAR1	RGD	RGD:2406
Bos taurus	BCAR1	VGNC	VGNC:26437

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