2. Gene
  3. SH2D3C - SH2 domain containing 3C Gene

SH2D3C - SH2 domain containing 3C Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：含 SH2 域 3C

种属: Homo sapiens

同用名: CHAT; NSP3; SHEP1; PRO34088

基因 ID: 10044 | 基因类型: protein coding

关于 SH2D3C

Cytogenetic location: 9q34.11 Genomic coordinates (GRCh38): 9:127,738,317-127,778,666 (from NCBI)

This gene has 13 transcripts (splice variants), 278 orthologues and 2 paralogues. Broad expression in spleen (RPKM 12.4), lung (RPKM 10.5) and 22 other tissues.

功能概要

该基因编码衔接蛋白和参与细胞迁移的细胞质蛋白家族成员。编码的蛋白质包含一个推定的 Src 同源 2 (SH2) 结构域和鸟嘌呤核苷酸交换因子样结构域，这允许该信号蛋白与支架蛋白 Crk 相关底物形成复合物。已发现该基因编码不同异构体的多个转录变体。[RefSeq 提供，2011 年 11 月]

This gene encodes an adaptor protein and member of a cytoplasmic protein family involved in cell migration. The encoded protein contains a putative Src homology 2 (SH2) domain and guanine nucleotide exchange factor-like domain which allows this signaling protein to form a complex with scaffolding protein Crk-associated substrate. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

SH2D3C 基因产物(7)

mRNA Protein Name
NM_001142531.1 NP_001136003.1 SH2 domain-containing protein 3C isoform c
NM_001142532.1 NP_001136004.1 SH2 domain-containing protein 3C isoform c
NM_001142533.1 NP_001136005.1 SH2 domain-containing protein 3C isoform d
NM_001142534.1 NP_001136006.1 SH2 domain-containing protein 3C isoform e
NM_001252334.2 NP_001239263.1 SH2 domain-containing protein 3C isoform f
NM_005489.4 NP_005480.2 SH2 domain-containing protein 3C isoform b
NM_170600.3 NP_733745.1 SH2 domain-containing protein 3C isoform a
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
22081014 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SH2D3C 蛋白结构

SH2

SH2: SH2 domain (220 - 300)

RasGEF

RasGEF: RasGEF domain (586 - 713)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 860 a.a.
蛋白主名 其他名称

SH2 domain-containing protein 3C

SH2 domain-containing Eph receptor-binding protein 1

SH2D3C 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
SH2D3C Q8N5H7 MET Homo sapiens P08581
FPS
24728074
种属内
SH2D3C Q8N5H7 KIT Homo sapiens P10721
FPS
24728074
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Eastern Equine Encephalitis

Eee

Neuroinvasive Eastern Equine Encephalitis Virus Infection

Eastern Equine Encephalomyelitis

Encephalomyelitis, Eastern Equine

Triple E

Eastern Equine Encephalitis Virus Infection

Neuroinvasive Eastern Equine Encephalitis Virus Disease

Eee - [Eastern Equine Encephalitis]
Western Equine Encephalitis

Western Equine Encephalomyelitis

Wee

Encephalomyelitis, Western Equine

Western Equine Encephalitis Virus Infection

Wee - [Western Equine Encephalitis]

Western Equine Encephalitis Virus
Blue Toe Syndrome
Noonan Syndrome 12

NS12
Venezuelan Equine Encephalitis

Venezuelan Equine Fever

Venezuelan Equine Encephalomyelitis

Encephalitis Venezuelan Equine

Encephalomyelitis, Venezuelan Equine

Venezuelan Encephalitis

Disorder Due To Venezuelan Equine Encephalitis Virus

Venezuelan Equine Encephalitis Virus Infection

Venezuelan Equine Encephalomyelitis Virus Disease
Ross River Fever

Ross River Virus Disease

Ross River Virus Infection
Noonan Syndrome 7

NS7

Noonan Syndrome, Type 7
Acute Diarrhea
Middle East Respiratory Syndrome

Mers

Mers - [Middle East Respiratory Syndrome]
Griscelli Syndrome, Type 3

Griscelli Syndrome Type 3

GS3

Griscelli-Prunieras Syndrome Type 3

Hypomelanosis With No Immunologic Or Neurologic Manifestations

Griscelli Syndrome 3
Coronavirus Infectious Disease
Ebola Hemorrhagic Fever

Ebola Virus Disease

Viral Hemorrhagic Fever

Hemorrhagic Fever, Ebola

Ebola

Ehf

Ebola Fever

Hemorrhagic Fevers, Viral

Ebola Haemorrhagic Fever

Ebod - [Ebola Disease]

Evd - [Ebola Virus Disease]

Ebola Virus Haemorrhagic Fever

Vhf - [Viral Haemorrhagic Fever] Nos

Viral Haemorrhagic Fever, Not Otherwise Specified
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS12824 SH2D3C Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus SH2D3C MGD MGI:1351631
Macaca mulatta SH2D3C VGNC VGNC:77253
Rattus norvegicus SH2D3C RGD RGD:1307287
Bos taurus SH2D3C VGNC VGNC:34559
Canis familiaris SH2D3C VGNC VGNC:46113
Felis catus SH2D3C VGNC VGNC:65094
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