1. Gene
  2. DTX3 - deltex E3 ubiquitin ligase 3 Gene

DTX3 - deltex E3 ubiquitin ligase 3 Gene

中文名称:deltex E3 泛素连接酶 3

种属: Homo sapiens

同用名: RNF154; deltex3

基因 ID: 196403 | 基因类型: protein coding

关于 DTX3

Cytogenetic location: 12q13.3 Genomic coordinates (GRCh38): 12:57,604,824-57,609,802 (from NCBI)

This gene has 9 transcripts (splice variants), 183 orthologues and 4 paralogues. Ubiquitous expression in brain (RPKM 21.6), endometrium (RPKM 16.7) and 24 other tissues.

功能概要

DTX3 作为 E3 泛素连接酶发挥作用 (Takeyama 等人,2003 [PubMed 12670957]) 。[OMIM 提供,2009 年 11 月]

DTX3 functions as an E3 ubiquitin Ligase (Takeyama et al., 2003 [PubMed 12670957]).[supplied by OMIM, Nov 2009]

DTX3 基因产物(3)

mRNA Protein Name
NM_001286245.2 NP_001273174.1 probable E3 ubiquitin-protein ligase DTX3 isoform b
NM_001286246.2 NP_001273175.1 probable E3 ubiquitin-protein ligase DTX3 isoform a
NM_178502.4 NP_848597.1 probable E3 ubiquitin-protein ligase DTX3 isoform a
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
19549727 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

DTX3 蛋白结构

zf-RING_2

zf-RING_2: Ring finger domain (163 - 202)

  • 0
  • 100
  • 200
  • 300
  • 347 a.a.
蛋白主名 其他名称

probable E3 ubiquitin-protein ligase DTX3

RING finger protein 154

DTX3 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra DTX3 Q8N9I9 NFKBID Homo sapiens Q8NI38
Validated Y2H
32296183
Intra DTX3 Q8N9I9 FYN Homo sapiens P06241-3
MAPPIT
32296183
Intra DTX3 Q8N9I9 UBASH3B Homo sapiens Q8TF42
Validated Y2H
32296183
Intra DTX3 Q8N9I9 PARP11 Homo sapiens Q9NR21-1
Validated Y2H
32296183
Intra DTX3 Q8N9I9 UBE2L6 Homo sapiens O14933
Y2H Array
19549727
Intra DTX3 Q8N9I9 TRAF4 Homo sapiens Q9BUZ4
Validated Y2H
32296183
Intra DTX3 Q8N9I9 UBE2K Homo sapiens P61086
Validated Y2H
25416956
Intra DTX3 Q8N9I9 SPRED1 Homo sapiens Q7Z699
Validated Y2H
32814053
Intra DTX3 Q8N9I9 SPRED1 Homo sapiens Q7Z699
Y2H Array
32814053
Intra DTX3 Q8N9I9 SPRED1 Homo sapiens Q7Z699
Y2H Pooling
32814053
Intra DTX3 Q8N9I9 UBE2D1 Homo sapiens P51668
Y2H Array
19549727
Intra DTX3 Q8N9I9 UBE2D4 Homo sapiens Q9Y2X8
Validated Y2H
32296183
Intra DTX3 Q8N9I9 ZMYND19 Homo sapiens Q96E35
Validated Y2H
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Cutaneous Diphtheria

Diphtheria Wound Infection

Arteriovenous Malformations Of The Brain

Cerebral Arteriovenous Malformation

Intracranial Arteriovenous Malformation

Intracranial Hemorrhage In Brain Cerebrovascular Malformations, Susceptibility To

Intracranial Arteriovenous Malformations

Bavm

Cerebral Arteriovenous Malformations

Intracranial Hemorrhage In Brain Cerebrovascular Malformations

Arteriovenous Malformation Of The Brain, Somatic

Intracranial Avm

Arteriovenous Malformations Cerebral

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Bos taurus DTX3 VGNC VGNC:28238
Mus musculus DTX3 MGD MGI:2135752
Rattus norvegicus DTX3 RGD RGD:1566181
Canis familiaris DTX3 VGNC VGNC:40117
Macaca mulatta DTX3 VGNC VGNC:71896
Felis catus DTX3 VGNC VGNC:61650
Others DTX3 NCBI