1. Gene
  2. EXOC5 - exocyst complex component 5 Gene

EXOC5 - exocyst complex component 5 Gene

中文名称:exocyst 复杂组件 5

种属: Homo sapiens

同用名: SEC10; HSEC10; SEC10P; PRO1912; SEC10L1

基因 ID: 10640 | 基因类型: protein coding

关于 EXOC5

Cytogenetic location: 14q22.3 Genomic coordinates (GRCh38): 14:57,200,507-57,268,905 (from NCBI)

This gene has 11 transcripts (splice variants) and 214 orthologues. Ubiquitous expression in testis (RPKM 17.5), brain (RPKM 9.4) and 25 other tissues.

功能概要

由该基因编码的蛋白质是胞吐复合物的一个组成部分,胞吐复合物是一种多蛋白复合物,对于将胞吐囊泡靶向质膜上的特定停靠位点至关重要。尽管在酵母中得到了最好的表征,但已证明 exocyst 复合体的成分蛋白质和功能在高等真核生物中高度保守。发现 exocyst 复合物的至少八种成分 (包括这种蛋白质) 与肌动蛋白细胞骨架重塑和囊泡转运机制相互作用。该复合物对于上皮细胞表面极性的生物发生也是必不可少的。[RefSeq 提供,2008 年 7 月]

The protein encoded by this gene is a component of the exocyst complex, a multiple protein complex essential for targeting exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and functions of exocyst complex have been demonstrated to be highly conserved in higher eukaryotes. At least eight components of the exocyst complex, including this protein, are found to interact with the actin cytoskeletal remodeling and vesicle transport machinery. The complex is also essential for the biogenesis of epithelial cell surface polarity. [provided by RefSeq, Jul 2008]

EXOC5 基因产物(1)

mRNA Protein Name
NM_006544.4 NP_006535.1 exocyst complex component 5
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
21516116 GOA
enables small GTPase binding IPI
IPI: 通过物理相互作用推断
24056301 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

EXOC5 蛋白结构

Sec10

Sec10: Exocyst complex component Sec10 (90 - 706)

  • 0
  • 200
  • 400
  • 600
  • 708 a.a.
蛋白主名 其他名称

exocyst complex component 5

SEC10-like 1

EXOC5 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
EXOC5 O00471 CCDC102B Homo sapiens Q68D86 25416956
种属内
EXOC5 O00471 TTC23L Homo sapiens Q6PF05-3 25416956
种属内
EXOC5 O00471 TTC23L Homo sapiens Q6PF05-3 25416956
种属内
EXOC5 O00471 RAB4B Homo sapiens P61018 32296183
种属内
EXOC5 O00471 EDRF1 Homo sapiens Q3B7T1-5 25416956
种属内
EXOC5 O00471 EDRF1 Homo sapiens Q3B7T1-5 25416956
种属内
EXOC5 O00471 MAGEA6 Homo sapiens P43360 32296183
种属内
EXOC5 O00471 MAGEA6 Homo sapiens P43360 32296183
种属内
EXOC5 O00471 MAGEA6 Homo sapiens P43360 32296183
种属内
EXOC5 O00471 RAB14 Homo sapiens P61106 25416956
种属内
EXOC5 O00471 RAB14 Homo sapiens P61106 32296183
种属内
EXOC5 O00471 RAB14 Homo sapiens P61106 25416956
种属内
EXOC5 O00471 OAS1 Homo sapiens P00973-2 32296183
种属内
EXOC5 O00471 EXOC6 Homo sapiens Q8TAG9
TAP
27173435
种属内
EXOC5 O00471 EXOC6 Homo sapiens Q8TAG9 32296183
种属内
EXOC5 O00471 BDNF Homo sapiens P23560-2 32814053
种属内
EXOC5 O00471 BDNF Homo sapiens P23560-2 32814053
种属内
EXOC5 O00471 BDNF Homo sapiens P23560-2 32814053
种属内
EXOC5 O00471 TSC1 Homo sapiens Q86WV8 32814053
种属内
EXOC5 O00471 TSC1 Homo sapiens Q86WV8 32814053
种属内
EXOC5 O00471 TSC1 Homo sapiens Q86WV8 32814053
种属内
EXOC5 O00471 PTK6 Homo sapiens Q13882 25416956
种属内
EXOC5 O00471 PTK6 Homo sapiens Q13882 32296183
种属内
EXOC5 O00471 PTK6 Homo sapiens Q13882 25416956
种属内
EXOC5 O00471 KIFC3 Homo sapiens Q9BVG8-5 32296183
种属内
EXOC5 O00471 KIFC3 Homo sapiens Q9BVG8-5 32296183
种属内
EXOC5 O00471 KIFC3 Homo sapiens Q9BVG8-5 32296183
种属内
EXOC5 O00471 THOC1 Homo sapiens Q96FV9 32296183
种属内
EXOC5 O00471 EXOC6B Homo sapiens Q9Y2D4 32296183
种属内
EXOC5 O00471 EXOC6B Homo sapiens Q9Y2D4 32296183
种属内
EXOC5 O00471 EXOC6B Homo sapiens Q9Y2D4 32296183
种属内
EXOC5 O00471 EXOC6B Homo sapiens Q9Y2D4
TAP
27173435
种属内
EXOC5 O00471 GAPDH Homo sapiens P04406 32814053
种属内
EXOC5 O00471 GAPDH Homo sapiens P04406 32814053
种属内
EXOC5 O00471 GAPDH Homo sapiens P04406 32814053
种属内
EXOC5 O00471 STUB1 Homo sapiens Q9UNE7 32814053
种属内
EXOC5 O00471 STUB1 Homo sapiens Q9UNE7 32814053
种属内
EXOC5 O00471 STUB1 Homo sapiens Q9UNE7 32814053
种属内
EXOC5 O00471 TARDBP Homo sapiens Q13148 32814053
种属内
EXOC5 O00471 TARDBP Homo sapiens Q13148 32814053
种属内
EXOC5 O00471 TARDBP Homo sapiens Q13148 32814053
种属内
EXOC5 O00471 OAS1 Homo sapiens P00973 25416956
种属内
EXOC5 O00471 OAS1 Homo sapiens P00973 25416956
种属内
EXOC5 O00471 TNPO2 Homo sapiens O14787 25416956
种属内
EXOC5 O00471 TNPO2 Homo sapiens O14787
Y2H
21516116
种属内
EXOC5 O00471 HTT Homo sapiens P42858 32814053
种属内
EXOC5 O00471 HTT Homo sapiens P42858 32814053
种属内
EXOC5 O00471 HTT Homo sapiens P42858 32814053
种属内
EXOC5 O00471 BARD1 Homo sapiens Q99728 25416956
种属内
EXOC5 O00471 PMP22 Homo sapiens A0A6Q8PF08 32814053
种属内
EXOC5 O00471 PMP22 Homo sapiens A0A6Q8PF08 32814053
种属内
EXOC5 O00471 PMP22 Homo sapiens A0A6Q8PF08 32814053
种属内
EXOC5 O00471 SPRED1 Homo sapiens Q7Z699 32814053
种属内
EXOC5 O00471 SPRED1 Homo sapiens Q7Z699 32814053
种属内
EXOC5 O00471 SPRED1 Homo sapiens Q7Z699 32814053
种属内
EXOC5 O00471 MAGEA3 Homo sapiens P43357 32296183
种属内
EXOC5 O00471 MAGEA3 Homo sapiens P43357 32296183
种属内
EXOC5 O00471 MAGEA3 Homo sapiens P43357 32296183
种属内
EXOC5 O00471 BRMS1L Homo sapiens Q5PSV4 25416956
种属内
EXOC5 O00471 BRMS1L Homo sapiens Q5PSV4 25416956
种属内
EXOC5 O00471 TXLNB Homo sapiens Q8N3L3 25416956
种属内
EXOC5 O00471 TXLNB Homo sapiens Q8N3L3 31515488
种属内
EXOC5 O00471 WFS1 Homo sapiens O76024 32814053
种属内
EXOC5 O00471 WFS1 Homo sapiens O76024 32814053
种属内
EXOC5 O00471 WFS1 Homo sapiens O76024 32814053
种属内
EXOC5 O00471 RAB4A Homo sapiens P20338 25416956
种属内
EXOC5 O00471 RAB4A Homo sapiens P20338 32296183
种属内
EXOC5 O00471 RAB4A Homo sapiens P20338 25416956
种属内
EXOC5 O00471 SPACA9 Homo sapiens Q96E40 25416956
种属内
EXOC5 O00471 SPACA9 Homo sapiens Q96E40 25416956
种属内
EXOC5 O00471 IFT57 Homo sapiens Q9NWB7 32296183
种属内
EXOC5 O00471 IFT57 Homo sapiens Q9NWB7 32296183
种属内
EXOC5 O00471 IFT57 Homo sapiens Q9NWB7 32296183
种属内
EXOC5 O00471 CRYAB Homo sapiens P02511 32814053
种属内
EXOC5 O00471 CRYAB Homo sapiens P02511 32814053
种属内
EXOC5 O00471 CRYAB Homo sapiens P02511 32814053
种属内
EXOC5 O00471 KXD1 Homo sapiens Q9BQD3 25416956
种属内
EXOC5 O00471 KXD1 Homo sapiens Q9BQD3 25416956
种属内
EXOC5 O00471 KXD1 Homo sapiens Q9BQD3 25416956
种属内
EXOC5 O00471 FRMD6 Homo sapiens Q96NE9 25416956
种属内
EXOC5 O00471 USP2 Homo sapiens O75604 32296183
种属内
EXOC5 O00471 TXNL4A Homo sapiens P83876 25416956
种属内
EXOC5 O00471 C1orf216 Homo sapiens Q8TAB5 32296183
种属内
EXOC5 O00471 DEUP1 Homo sapiens Q05D60 32296183
种属内
EXOC5 O00471 DEUP1 Homo sapiens Q05D60 25416956
种属内
EXOC5 O00471 DEUP1 Homo sapiens Q05D60 25416956
种属内
EXOC5 O00471 DEUP1 Homo sapiens Q05D60 32296183
种属内
EXOC5 O00471 DEUP1 Homo sapiens Q05D60 32296183
种属内
EXOC5 O00471 DEUP1 Homo sapiens Q05D60 25416956
种属内
EXOC5 O00471 HDDC3 Homo sapiens Q8N4P3 25416956
种属内
EXOC5 O00471 HDDC3 Homo sapiens Q8N4P3 25416956
种属内
EXOC5 O00471 PYCARD Homo sapiens Q9ULZ3 25416956
种属内
EXOC5 O00471 PYCARD Homo sapiens Q9ULZ3 25416956
种属内
EXOC5 O00471 PYCARD Homo sapiens Q9ULZ3 25416956
种属内
EXOC5 O00471 CRYBB1 Homo sapiens P53674 32296183
种属内
EXOC5 O00471 FGA Homo sapiens P02671-2 32296183
种属内
EXOC5 O00471 FGA Homo sapiens P02671-2 32296183
种属内
EXOC5 O00471 FGA Homo sapiens P02671-2 32296183
种属内
EXOC5 O00471 SNCA Homo sapiens P37840 32814053
种属内
EXOC5 O00471 SNCA Homo sapiens P37840 32814053
种属内
EXOC5 O00471 SNCA Homo sapiens P37840 32814053
种属内
EXOC5 O00471 BARD1 Homo sapiens A0AVN2 25416956
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Meckel Syndrome, Type 1

Meckel-Gruber Syndrome

Meckel Syndrome

Dysencephalia Splanchnocystica

Meckel Syndrome 1

MKS1

Mks

Gruber Syndrome

Meckel-Gruber Syndrome, Type 1

Mes

Dysencephalia Splachnocystica

Meckel Gruber Syndrome

Meckel Syndrome Type 1

Autosomal Dominant Polycystic Kidney Disease

Polycystic Kidney Disease, Adult Type

Adpkd

Polycystic Kidney Diseases

Polycystic Kidney, Autosomal Dominant

Congenital Biliary Ectasias

Polycystic Kidney And Hepatic Disease 1

Polycystic Kidney Disease, Autosomal Dominant

Kidney, Polycystic, Disease, Autosomal Dominant

Adult Polycystic Kidney Disease

Polycystic Kidney, Adult Type

Apckd - [Autosomal Polycystic Kidney Disease]

Nephronophthisis

Medullary Cystic Disease

Medullary Cystic Kidney

Nph

Nphp

Kidney Disease, Cystic, Medullary

Joubert Syndrome 1

Joubert Syndrome

Jbts

Cerebellooculorenal Syndrome 1

JBTS1

Joubert-Boltshauser Syndrome

Cerebelloparenchymal Disorder Iv

Cpd4

Cors1

Joubert Syndrome And Related Disorders

Jsrd

Familial Aplasia Of The Vermis

Joubert Syndrome Related Disorders

Js

Cerebellar Vermis Agenesis

Cerebelloparenchymal Disorder 4

Agenesis Of Cerebellar Vermis

Cerebello-Oculo-Renal Syndrome

Cors

Joubert-Bolthauser Syndrome

Cpd Iv

Classic Joubert Syndrome

Joubert Syndrome Type A

Pure Joubert Syndrome

Cerebello-Oculo-Renal Syndrome 1

Joubert Syndrome-1

Joubert Syndrome, Type 1

Joubert'S Syndrome

Polycystic Kidney Disease

Polycystic Kidney Diseases

Pkd

Polycystic Renal Disease

Kidney Disease, Polycystic

Polycystic Kidney, Autosomal Dominant

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta EXOC5 VGNC VGNC:72260
Mus musculus EXOC5 MGD MGI:2145645
Bos taurus EXOC5 VGNC VGNC:28649
Felis catus EXOC5 VGNC VGNC:62001
Rattus norvegicus EXOC5 RGD RGD:708408
Canis familiaris EXOC5 VGNC VGNC:40515
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