2. Gene
  3. OAS1 - 2'-5'-oligoadenylate synthetase 1 Gene

OAS1 - 2'-5'-oligoadenylate synthetase 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：2'-5'-寡聚腺苷酸合成酶 1

种属: Homo sapiens

同用名: OIAS; IFI-4; OIASI; IMD100; E18/E16

基因 ID: 4938 | 基因类型: protein coding

关于 OAS1

Cytogenetic location: 12q24.13 Genomic coordinates (GRCh38): 12:112,906,962-112,933,219 (from NCBI)

This gene has 33 transcripts (splice variants), 167 orthologues, 3 paralogues and is associated with 1 phenotype. Ubiquitous expression in spleen (RPKM 18.0), colon (RPKM 15.8) and 24 other tissues.

功能概要

这种干扰素诱导的基因编码一种合成 2',5'-寡聚腺苷酸 (2-5As) 的蛋白质。这种蛋白质在先天细胞抗病毒反应中起着关键作用，并与其他细胞过程如细胞生长和细胞凋亡有关。可变剪接导致具有不同酶活性的多个转录变体。该基因的多态性与病毒感染的易感性有关，包括 SARS-CoV-2 和 1 型糖尿病。该基因位于 12 号染色体上的一组相关基因中。[RefSeq 提供，2022 年 5 月]

This interferon-induced gene encodes a protein that synthesizes 2',5'-oligoadenylates (2-5As). This protein plays a key role in innate cellular Antiviral response, and has been implicated in other cellular processes like cell growth and Apoptosis. Alternative splicing results in multiple transcript variants with different enzymatic activities. Polymorphisms in this gene have been associated with susceptibility to viral Infection, including SARS-CoV-2, and diabetes mellitus, type 1. This gene is located in a cluster of related genes on chromosome 12. [provided by RefSeq, May 2022]

OAS1 基因产物(15)

mRNA Protein Name
NM_001032409.3 NP_001027581.1 2'-5'-oligoadenylate synthase 1 isoform 3
NM_001320151.2 NP_001307080.1 2'-5'-oligoadenylate synthase 1 isoform 4
NM_001406020.1 NP_001392949.1 2'-5'-oligoadenylate synthase 1 isoform 5
NM_001406021.1 NP_001392950.1 2'-5'-oligoadenylate synthase 1 isoform 6
NM_001406022.1 NP_001392951.1 2'-5'-oligoadenylate synthase 1 isoform 7
NM_001406023.1 NP_001392952.1 2'-5'-oligoadenylate synthase 1 isoform 8
NM_001406024.1 NP_001392953.1 2'-5'-oligoadenylate synthase 1 isoform 9
NM_001406025.1 NP_001392954.1 2'-5'-oligoadenylate synthase 1 isoform 10
NM_001406026.1 NP_001392955.1 2'-5'-oligoadenylate synthase 1 isoform 11
NM_001406027.1 NP_001392956.1 2'-5'-oligoadenylate synthase 1 isoform 12
NM_001406029.1 NP_001392958.1 2'-5'-oligoadenylate synthase 1 isoform 13
NM_001406030.1 NP_001392959.1 2'-5'-oligoadenylate synthase 1 isoform 14
NM_001412228.1 NP_001399157.1 2'-5'-oligoadenylate synthase 1 isoform 15
NM_002534.4 NP_002525.2 2'-5'-oligoadenylate synthase 1 isoform 2
NM_016816.4 NP_058132.2 2'-5'-oligoadenylate synthase 1 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables 2'-5'-oligoadenylate synthetase activity IDA
IDA: 通过直接分析推断
2434505 GOA
enables double-stranded RNA binding IDA
IDA: 通过直接分析推断
12799444 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
15039538 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in antiviral innate immune response IDA
IDA: 通过直接分析推断
34581622 GOA
involved in antiviral innate immune response IEP
IEP: 通过表达模式推断
25930096 GOA
involved in cellular response to interferon-alpha IDA
IDA: 通过直接分析推断
3753689 GOA
involved in cellular response to interferon-beta IDA
IDA: 通过直接分析推断
2434505 GOA
involved in cellular response to virus IEP
IEP: 通过表达模式推断
28146100 GOA
involved in defense response to bacterium IMP
IMP: 通过突变表型推断
30822544 GOA
involved in defense response to virus IDA
IDA: 通过直接分析推断
19923450 GOA
involved in glucose homeostasis IMP
IMP: 通过突变表型推断
23575436 GOA
involved in glucose metabolic process IMP
IMP: 通过突变表型推断
23575436 GOA
involved in interleukin-27-mediated signaling pathway IEP
IEP: 通过表达模式推断
32270034 GOA
involved in negative regulation of IP-10 production IMP
IMP: 通过突变表型推断
30078389 GOA
involved in negative regulation of chemokine (C-X-C motif) ligand 2 production IMP
IMP: 通过突变表型推断
30078389 GOA
involved in negative regulation of type I interferon-mediated signaling pathway IMP
IMP: 通过突变表型推断
30078389 GOA
involved in negative regulation of viral genome replication IDA
IDA: 通过直接分析推断
18931074 GOA
involved in positive regulation of cellular respiration IDA
IDA: 通过直接分析推断
31817188 GOA
involved in positive regulation of interferon-beta production IMP
IMP: 通过突变表型推断
30822544 GOA
involved in positive regulation of monocyte chemotactic protein-1 production IMP
IMP: 通过突变表型推断
30822544 GOA
involved in positive regulation of tumor necrosis factor production IMP
IMP: 通过突变表型推断
30822544 GOA
involved in protein complex oligomerization IDA
IDA: 通过直接分析推断
11682059 GOA
involved in regulation of ribonuclease activity IDA
IDA: 通过直接分析推断
19923450 GOA
involved in response to virus IDA
IDA: 通过直接分析推断
18931074 GOA
involved in surfactant homeostasis IMP
IMP: 通过突变表型推断
29455859 GOA
involved in toll-like receptor 3 signaling pathway IMP
IMP: 通过突变表型推断
30078389 GOA
involved in toll-like receptor 4 signaling pathway IMP
IMP: 通过突变表型推断
30078389 GOA
involved in type I interferon-mediated signaling pathway IMP
IMP: 通过突变表型推断
28640813 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
colocalizes with cytoplasm IDA
IDA: 通过直接分析推断
21245038 GOA
located in cytoplasm IDA
IDA: 通过直接分析推断
3753689 GOA
located in cytosol IDA
IDA: 通过直接分析推断
31817188 GOA
located in mitochondrion IDA
IDA: 通过直接分析推断
25205466 GOA
is active in nucleus IDA
IDA: 通过直接分析推断
2434505 GOA
located in nucleus IDA
IDA: 通过直接分析推断
3753689 GOA
located in ribosome IDA
IDA: 通过直接分析推断
2434505 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

OAS1 蛋白结构

NTP_transf_2

NTP_transf_2: Nucleotidyltransferase domain (52 - 104)

OAS1_C

OAS1_C: 2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus (163 - 345)

  • 0
  • 100
  • 200
  • 300
  • 400 a.a.
蛋白主名 其他名称

2'-5'-oligoadenylate synthase 1

(2-5')oligo(A) synthase 1

OAS1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra OAS1 P00973 ACTN1 Homo sapiens P12814
Validated Y2H
25416956
Intra OAS1 P00973 TRIM27 Homo sapiens P14373
Y2H Array
31515488
Intra OAS1 P00973 EXOC5 Homo sapiens O00471
Validated Y2H
25416956
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Immunodeficiency 100 With Pulmonary Alveolar Proteinosis And Hypogammaglobulinemia

Pulmonary Alveolar Proteinosis With Hypogammaglobulinemia

IMD100

Paphg
Infantile-Onset Pulmonary Alveolar Proteinosis-Hypogammaglobulinemia

Oas1 Deficiency

Oas1-Related Infantile-Onset Pulmonary Alveolar Proteinosis-Hypogammaglobulinemia
Microphthalmia With Limb Anomalies

Waardenburg Anophthalmia Syndrome

Ophthalmoacromelic Syndrome

OAS

MLA

Anophthalmia-Syndactyly

Anophthalmia-Syndactyly Syndrome

Anophthalmos With Limb Anomalies

Anophthalmia Waardenburg Syndrome

Anophthalmos-Syndactyly

Ophthalmo-Acromelic Syndrome

Anophthalmia-Waardenburg Syndrome

Anophthalmos-Limb Anomalies Syndrome

Syndactyly-Anophthalmos Syndrome

Microphthalmia, With Limb Anomalies
Hand, Foot And Mouth Disease

Vesicular Stomatitis And Exanthem
Measles

Rubeola

Morbilli

Measles Nos

Koplik Spots
West Nile Fever
Yellow Fever

Urban Yellow Fever

Jungle Yellow Fever

Sylvatic Yellow Fever

Yf

Yellow Fever, Sylvan

Bronze John

Yellow Jack

Yf- [Yellow Fever]

Febris Flava
Herpes Simplex

Herpes Simplex Infections

Herpesvirus Hominis Disease

Herpes Simplex Disease

Herpesviral Infection Due To Herpes Simplex

Infections Due To Simplex Virus

Herpes Nos
Pulmonary Alveolar Proteinosis
Viral Infectious Disease

Viral Disease

Arbovirus Infections

Virus Infection

Virus Diseases

Viral Infection

Viral Infections

Virus Infections
Rubella

German Measles

Three Day Measles

Rubella Nos
West Nile Virus

West Nile Virus, Susceptibility To

Wnv

Wnv, Susceptibility To

West Nile Viral Infection

Encephalitis, West Nile Fever

West Nile Fever
Mouth Disease

Mouth Diseases

Mouth Disorders
Diabetes Mellitus

Diabetes
Systemic Lupus Erythematosus

Lupus Nephritis

SLE

Disseminated Lupus Erythematosus

Systemic Lupus Erythematosus, Susceptibility To

Lupus Erythematosus, Systemic

Lupus Nephritis, Susceptibility To

Libman-Sacks Disease

Systemic Lupus Erythematosus Susceptibility To

Sle - Lupus Erythematosus, Systemic

Le Syndrome

Lupus

Lupus Erythematosus Systemic

Lupus Erythematosus, Systemic, Susceptibility To

Lupus Vulgaris

Lupus Erythematosus, Discoid

Lupus Erythematosus

Systemic Lupus Erythematosus Nos

Sle - [Systemic Lupus Erythematosus]
Aicardi-Goutieres Syndrome

Aicardi Goutieres Syndrome

Cree Encephalitis

Aicardi-Goutières Syndrome

Encephalopathy With Basal Ganglia Calcification

Ags

Encephalopathy With Intracranial Calcification And Chronic Lymphocytosis Of Cerebrospinal Fluid

Pseudotoxoplasmosis Syndrome

Encephalopathy, Familial Infantile, With Calcification Of Basal Ganglia And Chronic Cerebrospinal Fluid Lymphocytosis

Familial Infantile Encephalopathy With Intracranial Calcification And Chronic Cerebrospinal Fluid Lymphocytosis

Aicardi-Goutieres Syndrome 1
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS09727 OAS1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus OAS1 VGNC VGNC:68606
Macaca mulatta OAS1 VGNC VGNC:75570
Rattus norvegicus OAS1 RGD RGD:621760
Canis familiaris OAS1 VGNC VGNC:44086
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