RAB4A - RAB4A, member RAS oncogene family Gene

中文名称：RAB4A，RAS 致癌基因家族成员

种属: Homo sapiens

同用名: RAB4; HRES1; HRES-1; HRES-1/RAB4

基因 ID: 5867 | 基因类型: protein coding

关于 RAB4A

Cytogenetic location: 1q42.13 Genomic coordinates (GRCh38): 1:229,271,111-229,305,894 (from NCBI)

This gene has 5 transcripts (splice variants), 206 orthologues and 68 paralogues. Ubiquitous expression in prostate (RPKM 22.3), heart (RPKM 17.5) and 25 other tissues.

功能概要

该基因是小 GTP 酶 Ras 超家族中最大的一个基因组的成员，它调节膜运输。编码的蛋白质与早期内体相关，并参与它们的分类和回收。该蛋白质还在调节受体从核内体到质膜的再循环中发挥作用。已观察到该基因的可变剪接转录物变体。[RefSeq 提供，2012 年 12 月]

This gene is a member of the largest group in the Ras superfamily of small GTPases, which regulate membrane trafficking. The encoded protein is associated with early endosomes and is involved in their sorting and recycling. The protein also plays a role in regulating the recycling of receptors from endosomes to the plasma membrane. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2012]

RAB4A 基因产物(2)

mRNA	Protein	Name
NM_001271998.2	NP_001258927.1	ras-related protein Rab-4A isoform 2
NM_004578.4	NP_004569.2	ras-related protein Rab-4A isoform 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables GDP binding	IDA IDA: 通过直接分析推断	15907487	GOA
enables GTP binding	IDA IDA: 通过直接分析推断	15907487	GOA
enables GTPase activity	IDA IDA: 通过直接分析推断	15907487	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	16034420	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in antigen processing and presentation	IMP IMP: 通过突变表型推断	19717423	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in extracellular exosome	IDA IDA: 通过直接分析推断	15326289	GOA
located in perinuclear region of cytoplasm	IDA IDA: 通过直接分析推断	19590752	GOA
located in vesicle	IDA IDA: 通过直接分析推断	19590752	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

蛋白主名

其他名称

ras-related protein Rab-4A

HTLV-1 related endogenous sequence

RAB4A 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	RAB4A	P20338	GDI2	Homo sapiens	P50395	Anti Tag CoIP	33961781
Intra	RAB4A	P20338	GDI2	Homo sapiens	P50395	Anti Tag CoIP	19570034
Intra	RAB4A	P20338	GDI2	Homo sapiens	P50395	Anti Tag CoIP	35271311
Intra	RAB4A	P20338	RBSN	Homo sapiens	Q9H1K0	Validated Y2H	32296183
Intra	RAB4A	P20338	RBSN	Homo sapiens	Q9H1K0	BRET	29997244
Intra	RAB4A	P20338	RBSN	Homo sapiens	Q9H1K0	Y2H Prey Pooling	32296183
Intra	RAB4A	P20338	RBSN	Homo sapiens	Q9H1K0	Y2H Array	32296183
Intra	RAB4A	P20338	KCTD7	Homo sapiens	Q96MP8-2	Validated Y2H	32296183
Intra	RAB4A	P20338	HACE1	Homo sapiens	Q8IYU2	Y2H Array	32296183
Intra	RAB4A	P20338	HACE1	Homo sapiens	Q8IYU2	Y2H Prey Pooling	32296183
Intra	RAB4A	P20338	HACE1	Homo sapiens	Q8IYU2	Validated Y2H	32296183
Intra	RAB4A	P20338	RABEP1	Homo sapiens	Q15276	Y2H Prey Pooling	32296183
Intra	RAB4A	P20338	RABEP1	Homo sapiens	Q15276	Validated Y2H	32296183
Intra	RAB4A	P20338	RABEP1	Homo sapiens	Q15276	Y2H Array	32296183
Intra	RAB4A	P20338	GRIPAP1	Homo sapiens	Q4V328	Y2H	21988832
Intra	RAB4A	P20338	GRIPAP1	Homo sapiens	Q4V328	Validated Y2H	32296183
Intra	RAB4A	P20338	GRIPAP1	Homo sapiens	Q4V328	Y2H Array	32296183
Intra	RAB4A	P20338	GRIPAP1	Homo sapiens	Q4V328	Y2H Prey Pooling	32296183
Intra	RAB4A	P20338	GARIN6	Homo sapiens	Q8NEG0	Y2H Array	32296183
Intra	RAB4A	P20338	GARIN6	Homo sapiens	Q8NEG0	Y2H Prey Pooling	32296183
Intra	RAB4A	P20338	GARIN6	Homo sapiens	Q8NEG0	Validated Y2H	32296183
Intra	RAB4A	P20338	GDI1	Homo sapiens	P31150	Anti Tag CoIP	35271311
Intra	RAB4A	P20338	EXOC5	Homo sapiens	O00471	Y2H Array	25416956
Intra	RAB4A	P20338	EXOC5	Homo sapiens	O00471	Y2H Prey Pooling	32296183
Intra	RAB4A	P20338	EXOC5	Homo sapiens	O00471	Y2H Array	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Pontocerebellar Hypoplasia, Type 2e

Pontocerebellar Hypoplasia Type 2	Pontocerebellar Hypoplasia Type 2e
Pch2	PCH2E
Progressive Microcephaly From Birth Extrapyramidal Dyskinesia Chorea Epilepsy	Pontocerebellar Hypoplasia 2e
Pcca2	Progressive Cerebello-Cerebral Atrophy Type 2
Doid:0112328	Hypoplasia, Pontocerebellar, Type 2e
Pontocerebellar Hypoplasia, Type 2d	Pontocerebellar Hypoplasia Type 2a

Diffuse Infiltrative Lymphocytosis Syndrome

Charcot-Marie-Tooth Disease, Type 4d

Charcot-Marie-Tooth Disease Type 4d	CMT4D
Hmsnl	Hmsn4d
Charcot-Marie-Tooth Neuropathy Type 4d	Hereditary Motor And Sensory Neuropathy Lom Type
Hmsn-Lom	Neuropathy, Hereditary Motor And Sensory, Lom Type
Charcot-Marie-Tooth Disease, Demyelinating, Autosomal Recessive, Type 4d	Charcot-Marie-Tooth Neuropathy, Type 4d
Autosomal Recessive Demyelinating Charcot-Marie-Tooth Disease Type 4d	Hmsn Lom Type
Hmsn, Lom Type	Hereditary Motor And Sensory Neuropathy, Lom Type
Charcot-Marie-Tooth Disease 4d	Charcot-Marie-Tooth Disease Demyelinating Autosomal Recessive 4d
Hereditary Motor And Sensory Neuropathy Ivd	Hmsn Ivd

Charcot-Marie-Tooth Disease, Axonal, Type 2b

Charcot-Marie-Tooth Disease Type 2b	CMT2B
Hmsn Iib	Hmsn2b
Charcot-Marie-Tooth Disease, Type 2b	Hereditary Motor And Sensory Neuropathy Iib
Autosomal Dominant Charcot-Marie-Tooth Disease Type 2b	Charcot-Marie-Tooth Neuropathy Type 2b
Charcot-Marie-Tooth Disease, Autosomal Dominant, Type 2b	Charcot-Marie-Tooth Neuropathy, Type 2b
Hereditary Motor And Sensory Nueropathy Iib	Cmt 2b
Charcot Marie Tooth Disease Type 2b	Charcot-Marie-Tooth Disease, Neuronal, Type 2b
Hereditary Motor And Sensory Neuropathy 2 B	Peripheral Sensory Neuropathy, Autosomal Dominant
Charcot-Marie-Tooth Disease 2b	Charcot-Marie-Tooth Disease Axonal Type 2b
Charcot-Marie-Tooth Disease Neuronal Type 2b	Peripheral Sensory Neuropathy Autosomal Dominant
Psn

Chronic Myelomonocytic Leukemia

Leukemia, Myelomonocytic, Chronic	Cmml
Leukemia Myelomonocytic Chronic	Cmml - [Chronic Myelomonocytic Leukaemia]
Chronic Myelomonocytic Leukaemia Without Mention Of Remission	Chronic Monocytic Leukaemia
Chronic Monocytoid Leukaemia

Neuropathy, Congenital Hypomyelinating, 1, Autosomal Recessive

Charcot-Marie-Tooth Disease Type 4	Charcot-Marie-Tooth Disease Type 4e
Hereditary Motor And Sensory Neuropathy	Cmt4e
CHN1	Hypomyelinating Neuropathy, Congenital, 1
Charcot-Marie-Tooth Neuropathy Type 4e	Neuropathy, Congenital Hypomyelinating, 1
Ar-Cmt1	Autosomal Recessive Demyelinating Charcot-Marie-Tooth
Cmt4	Neuropathy, Congenital Hypomyelinating Or Amyelinating, Autosomal Recessive
Hypomyelination, Severe Congenital	Charcot-Marie-Tooth Disease, Type 4e
Charcot-Marie-Tooth Neuropathy, Type 4e	Autosomal Recessive Congenital Hypomyelinating Or Amyelinating Neuropathy
Autosomal Recessive Congenital Hypomyelinating Neuropathy	Congenital Amyelinating Neuropathy
Congenital Hypomyelinating Neuropathy Autosomal Recessive	Neuropathy, Congenital Hypomyelinating Or Amyelinating
Severe Congenital Hypomyelination	Hereditary Sensory Motor Neuropathy
Charcot-Marie-Tooth Disease, Demyelinating, Autosomal Recessive	Neuropathy, Hypomyelinating, Congenital, Type 1
Neuropathy, Motor And Sensory, Hereditary	Congenital Hypomyelinating Neuropathy
Hereditary Motor And Sensory Neuropathies	Hereditary Sensorimotor Neuropathy
Hmsn - [Hereditary Motor And Sensory Neuropathy]	Hsmn - [Hereditary Sensory And Motor Neuropathy]
Hereditary Motor And Sensory Neuropathy, Types I-Iv

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS11569	RAB4A Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Macaca mulatta	RAB4A	VGNC	VGNC:81545
Rattus norvegicus	RAB4A	RGD	RGD:3529
Canis familiaris	RAB4A	VGNC	VGNC:45290
Mus musculus	RAB4A	MGD	MGI:105069
Bos taurus	RAB4A	VGNC	VGNC:33657

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

RAB4A - RAB4A, member RAS oncogene family Gene

关于 RAB4A

功能概要

RAB4A 基因产物(2)

RAB4A 蛋白互作信息

关联疾病

直系同源

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RAB4A - RAB4A, member RAS oncogene family Gene

关于 RAB4A

功能概要

RAB4A 基因产物(2)

RAB4A 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z