1. Gene
  2. HOOK3 - hook microtubule tethering protein 3 Gene

HOOK3 - hook microtubule tethering protein 3 Gene

中文名称:钩状微管束缚蛋白 3

种属: Homo sapiens

同用名: HK3

基因 ID: 84376 | 基因类型: protein coding

关于 HOOK3

Cytogenetic location: 8p11.21 Genomic coordinates (GRCh38): 8:42,896,978-43,030,535 (from NCBI)

This gene has 6 transcripts (splice variants), 217 orthologues, 5 paralogues and is associated with 77 phenotypes. Ubiquitous expression in thyroid (RPKM 6.6), fat (RPKM 4.5) and 25 other tissues.

功能概要

Hook 蛋白是胞质卷曲螺旋蛋白,包含附着于微管的保守 N 末端结构域和介导与细胞器结合的更多不同的 C 末端结构域。果蝇 Hook 蛋白是内吞隔室的一个组成部分。[OMIM 提供,2004 年 4 月]

Hook proteins are cytosolic coiled-coil proteins that contain conserved N-terminal domains, which attach to microtubules, and more divergent C-terminal domains, which mediate binding to organelles. The Drosophila Hook protein is a component of the endocytic compartment.[supplied by OMIM, Apr 2004]

HOOK3 基因产物(1)

mRNA Protein Name
NM_032410.4 NP_115786.1 protein Hook homolog 3
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables dynactin binding IDA
IDA: 通过直接分析推断
27482052 GOA
enables dynein intermediate chain binding IDA
IDA: 通过直接分析推断
27482052 GOA
enables dynein light chain binding IPI
IPI: 通过物理相互作用推断
27482052 GOA
enables identical protein binding IPI
IPI: 通过物理相互作用推断
18799622 GOA
enables microtubule binding IDA
IDA: 通过直接分析推断
11238449 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
17237231 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in Golgi localization IMP
IMP: 通过突变表型推断
11238449 GOA
involved in cytoplasmic microtubule organization IMP
IMP: 通过突变表型推断
11238449 GOA
involved in early endosome to late endosome transport IMP
IMP: 通过突变表型推断
18799622 GOA
involved in endosome organization IMP
IMP: 通过突变表型推断
18799622 GOA
involved in endosome to lysosome transport IMP
IMP: 通过突变表型推断
18799622 GOA
involved in lysosome organization IMP
IMP: 通过突变表型推断
18799622 GOA
involved in protein localization to perinuclear region of cytoplasm IMP
IMP: 通过突变表型推断
32073997 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of FHF complex IDA
IDA: 通过直接分析推断
18799622 GOA
part of HOPS complex IDA
IDA: 通过直接分析推断
18799622 GOA
located in cis-Golgi network IDA
IDA: 通过直接分析推断
11238449 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

HOOK3 蛋白结构

HOOK

HOOK: HOOK protein (6 - 717)

  • 0
  • 200
  • 400
  • 600
  • 718 a.a.
蛋白主名 其他名称

protein Hook homolog 3

h-hook3

HOOK3 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra HOOK3 Q86VS8 PNMA5 Homo sapiens Q96PV4
Validated Y2H
32296183
Intra HOOK3 Q86VS8 PNMA5 Homo sapiens Q96PV4
Y2H Array
32296183
Intra HOOK3 Q86VS8 PNMA5 Homo sapiens Q96PV4
Y2H Prey Pooling
32296183
Intra HOOK3 Q86VS8 CTIF Homo sapiens O43310-2
Y2H Prey Pooling
32296183
Intra HOOK3 Q86VS8 CTIF Homo sapiens O43310-2
Y2H Array
32296183
Intra HOOK3 Q86VS8 KRT13 Homo sapiens P13646
Y2H Prey Pooling
32296183
Intra HOOK3 Q86VS8 KRT13 Homo sapiens P13646
Y2H Array
32296183
Intra HOOK3 Q86VS8 MEOX2 Homo sapiens Q6FHY5
Y2H Prey Pooling
32296183
Intra HOOK3 Q86VS8 MEOX2 Homo sapiens Q6FHY5
Y2H Array
32296183
Intra HOOK3 Q86VS8 MSR1 Homo sapiens P21757
Pull Down
17237231
Intra HOOK3 Q86VS8 MSR1 Homo sapiens P21757
Anti Tag CoIP
17237231
Intra HOOK3 Q86VS8 KRT27 Homo sapiens Q7Z3Y8
Y2H Array
32296183
Intra HOOK3 Q86VS8 KRT27 Homo sapiens Q7Z3Y8
Y2H Prey Pooling
32296183
Intra HOOK3 Q86VS8 AKTIP Homo sapiens Q9H8T0
Y2H
32073997
Intra HOOK3 Q86VS8 HOOK1 Homo sapiens Q9UJC3
Y2H
32073997
Intra HOOK3 Q86VS8 HOOK1 Homo sapiens Q9UJC3
Anti Tag CoIP
33961781
Intra HOOK3 Q86VS8 HOOK1 Homo sapiens Q9UJC3
Y2H Prey Pooling
32296183
Intra HOOK3 Q86VS8 HOOK1 Homo sapiens Q9UJC3
Anti Tag CoIP
28514442
Intra HOOK3 Q86VS8 HOOK1 Homo sapiens Q9UJC3
Validated Y2H
32296183
Intra HOOK3 Q86VS8 HOOK1 Homo sapiens Q9UJC3
Y2H Array
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Small Intestine Neuroendocrine Neoplasm

Small Intestine Neuroendocrine Tumor

Neuroendocrine Tumor Of The Small Intestine

Net Of The Small Intestine

Neuroendocrine Neoplasm Of The Small Intestine

Neuroendocrine Tumor Of Small Bowel

Small Intestinal Neuroendocrine Neoplasm

Dystonia 6, Torsion

DYT6

Torsion Dystonia 6

Dystonia 6

Idiopathic Torsion Dystonia Of Mixed Type

Primary Dystonia, Dyt6 Type

Torsion Dystonia, Adult-Onset, Mixed Type

Dyt-Thap1

Adolescent-Onset Dystonia Of Mixed Type

Torsion Dystonia Adult Onset Mixed Type

Dyt6 Dystonia

Thap1 Dystonia

Generalized Cervical And Upper-Limb-Onset Dystonia

Adult-Onset Torsion Dystonia Mixed Type

Autosomal Dominant Torsion Dystonia 6

Dystonia-6

Torsion Dystonia Type 6

Dystonia, Type 6, Torsion

Hermansky-Pudlak Syndrome 9

HPS9

Albinism With Hemorrhagic Diathesis And Pigmented Reticuloendothelial

Delta Storage Pool Disease

Hermansky-Pudlak Syndrome, Type 9

Platelet Storage Pool Deficiency

Albinism With Hemorrhagic Diathesis And Pigmented Reticuloendothelial Cells

Small Intestine Benign Neoplasm

Neoplasm Of Small Intestine

Small Intestinal Neoplasm

Neoplasm Of The Small Intestine

Small Bowel Cancer

Small Intestine Cancer

Malignant Neoplasm Of Small Intestine, Unspecified

Malignant Tumour Of Small Bowel

Malignant Tumour Of Small Intestine

Primary Malignant Neoplasm Of Meckel Diverticulum

Spinal Muscular Atrophy With Lower Extremity Predominant

Spinal Muscular Atrophy With Lower Extremity Predominance

Autosomal Dominant Childhood-Onset Proximal Spinal Muscular Atrophy With Contractures

Kugelberg-Welander Syndrome, Autosomal Dominant

Lower Extremity-Predominant Autosomal Dominant Proximal Spinal Muscular Atrophy With Contractures

Sma-Led

Spinal Muscular Atrophy, Childhood, Proximal, Autosomal Dominant

Spinal Muscular Atrophy, Juvenile, Proximal, Autosomal Dominant

Spinal Muscular Atrophy, Lower Extremity, Autosomal Dominant

Spinal Muscular Atrophy, Lower Extremity, Dominant

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Mus musculus HOOK3 MGD MGI:2443554
Rattus norvegicus HOOK3 RGD RGD:1560960
Macaca mulatta HOOK3 VGNC VGNC:73433
Bos taurus HOOK3 VGNC VGNC:50090
Canis familiaris HOOK3 VGNC VGNC:41742
Felis catus HOOK3 VGNC VGNC:62834