AKTIP - AKT interacting protein Gene

中文名称：AKT 相互作用蛋白

种属: Homo sapiens

同用名: FT1; FTS

关于 AKTIP

功能概要

该基因的小鼠同系物在杂合突变动物中产生融合脚趾和胸腺增生，而纯合突变动物在早期发育中死亡。该基因可能在细胞凋亡中发挥作用，因为这些形态学异常是由程序性细胞死亡模式改变引起的。该基因编码的蛋白质类似于其他泛素结合酶的泛素连接酶结构域，但缺少使这些酶能够将泛素结合到靶蛋白的保守半胱氨酸残基。该蛋白直接与丝氨酸/苏氨酸激酶蛋白激酶 B (PKB) /Akt 相互作用，并通过增强 PKB 调节位点的磷酸化来调节 PKB 活性。可变剪接导致编码相同蛋白质的两个转录变体。[RefSeq 提供，2008 年 7 月]

The mouse homolog of this gene produces fused toes and thymic hyperplasia in heterozygous mutant Animals while homozygous mutants die in early development. This gene may play a role in Apoptosis as these morphological abnormalities are caused by altered patterns of programmed cell death. The protein encoded by this gene is similar to the ubiquitin Ligase domain of other ubiquitin-conjugating Enzymes but lacks the conserved cysteine residue that enables those Enzymes to conjugate ubiquitin to the target protein. This protein interacts directly with serine/threonine kinase protein kinase B (PKB)/Akt and modulates PKB activity by enhancing the phosphorylation of PKB's regulatory sites. Alternative splicing results in two transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]