2. Gene
  3. HOOK2 - hook microtubule tethering protein 2 Gene

HOOK2 - hook microtubule tethering protein 2 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：钩状微管束缚蛋白 2

种属: Homo sapiens

同用名: HK2

基因 ID: 29911 | 基因类型: protein coding

关于 HOOK2

Cytogenetic location: 19p13.13 Genomic coordinates (GRCh38): 19:12,763,003-12,792,350 (from NCBI)

This gene has 25 transcripts (splice variants), 192 orthologues and 5 paralogues. Ubiquitous expression in fat (RPKM 18.1), duodenum (RPKM 14.2) and 24 other tissues.

功能概要

Hook 蛋白是胞质卷曲螺旋蛋白，包含附着于微管的保守 N 末端结构域和介导与细胞器结合的更多不同的 C 末端结构域。果蝇 Hook 蛋白是内吞隔室的一个组成部分。[OMIM 提供，2004 年 4 月]

Hook proteins are cytosolic coiled-coil proteins that contain conserved N-terminal domains, which attach to microtubules, and more divergent C-terminal domains, which mediate binding to organelles. The Drosophila Hook protein is a component of the endocytic compartment.[supplied by OMIM, Apr 2004]

HOOK2 基因产物(9)

mRNA Protein Name
NM_001100176.2 NP_001093646.1 protein Hook homolog 2 isoform 2
NM_001400041.1 NP_001386970.1 protein Hook homolog 2 isoform 3
NM_001400043.1 NP_001386972.1 protein Hook homolog 2 isoform 4
NM_001400044.1 NP_001386973.1 protein Hook homolog 2 isoform 4
NM_001400045.1 NP_001386974.1 protein Hook homolog 2 isoform 4
NM_001400046.1 NP_001386975.1 protein Hook homolog 2 isoform 4
NM_001400047.1 NP_001386976.1 protein Hook homolog 2 isoform 4
NM_001400048.1 NP_001386977.1 protein Hook homolog 2 isoform 4
NM_013312.3 NP_037444.2 protein Hook homolog 2 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables identical protein binding IPI
IPI: 通过物理相互作用推断
18799622 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
16189514 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in early endosome to late endosome transport IMP
IMP: 通过突变表型推断
18799622 GOA
involved in endosome organization IMP
IMP: 通过突变表型推断
18799622 GOA
involved in endosome to lysosome transport IMP
IMP: 通过突变表型推断
18799622 GOA
involved in lysosome organization IMP
IMP: 通过突变表型推断
18799622 GOA
involved in protein localization to perinuclear region of cytoplasm IMP
IMP: 通过突变表型推断
32073997 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of FHF complex IDA
IDA: 通过直接分析推断
18799622 GOA
part of HOPS complex IDA
IDA: 通过直接分析推断
18799622 GOA
located in centrosome IDA
IDA: 通过直接分析推断
17140400 GOA
located in trans-Golgi network IDA
IDA: 通过直接分析推断
32073997 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

HOOK2 蛋白结构

HOOK

HOOK: HOOK protein (1 - 710)

  • 0
  • 200
  • 400
  • 600
  • 719 a.a.
蛋白主名 其他名称

protein Hook homolog 2

h-hook2

HOOK2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
HOOK2 Q96ED9 UTP14C Homo sapiens Q08E77
Y2H Prey Pooling
25416956
种属内
HOOK2 Q96ED9 UTP14C Homo sapiens Q08E77
Validated Y2H
25416956
种属内
HOOK2 Q96ED9 UTP14C Homo sapiens Q08E77
Y2H Array
25416956
种属内
HOOK2 Q96ED9 SUV39H1 Homo sapiens O43463
Y2H
21516116
种属内
HOOK2 Q96ED9 SUV39H1 Homo sapiens O43463
Y2H Prey Pooling
25416956
种属内
HOOK2 Q96ED9 SUV39H1 Homo sapiens O43463
Validated Y2H
25416956
种属内
HOOK2 Q96ED9 SUV39H1 Homo sapiens O43463
Y2H Array
25416956
种属内
HOOK2 Q96ED9 AP1M1 Homo sapiens Q9BXS5
Validated Y2H
25416956
种属内
HOOK2 Q96ED9 CWF19L2 Homo sapiens Q2TBE0
Y2H Prey Pooling
25416956
种属内
HOOK2 Q96ED9 CWF19L2 Homo sapiens Q2TBE0
Validated Y2H
25416956
种属内
HOOK2 Q96ED9 CWF19L2 Homo sapiens Q2TBE0
Y2H Array
25416956
种属内
HOOK2 Q96ED9 FHIP2A Homo sapiens Q5W0V3
Anti Tag CoIP
34882091
种属内
HOOK2 Q96ED9 FHIP2A Homo sapiens Q5W0V3
BioID
34882091
种属内
HOOK2 Q96ED9 AKTIP Homo sapiens Q9H8T0
Y2H Array
31515488
种属内
HOOK2 Q96ED9 AKTIP Homo sapiens Q9H8T0
BioID
34882091
种属内
HOOK2 Q96ED9 AKTIP Homo sapiens Q9H8T0
Y2H Pooling
16189514
种属内
HOOK2 Q96ED9 AKTIP Homo sapiens Q9H8T0
Y2H Fragment Pooling
23414517
种属内
HOOK2 Q96ED9 AKTIP Homo sapiens Q9H8T0
Y2H
32073997
种属内
HOOK2 Q96ED9 KANSL1 Homo sapiens Q7Z3B3
Y2H Prey Pooling
25416956
种属内
HOOK2 Q96ED9 KANSL1 Homo sapiens Q7Z3B3
Y2H Array
25416956
种属内
HOOK2 Q96ED9 ZC2HC1C Homo sapiens Q53FD0
Y2H Prey Pooling
25416956
种属内
HOOK2 Q96ED9 ZC2HC1C Homo sapiens Q53FD0
Y2H Array
25416956
种属内
HOOK2 Q96ED9 ZC2HC1C Homo sapiens Q53FD0
Validated Y2H
25416956
种属内
HOOK2 Q96ED9 CCDC33 Homo sapiens Q8N5R6
Y2H Pooling
16189514
种属内
HOOK2 Q96ED9 ANKRD36BP1 Homo sapiens Q96IX9
Y2H Prey Pooling
25416956
种属内
HOOK2 Q96ED9 DUSP13B Homo sapiens Q9UII6
Validated Y2H
25416956
种属内
HOOK2 Q96ED9 DUSP13B Homo sapiens Q9UII6
Y2H Array
25416956
种属内
HOOK2 Q96ED9 DUSP13B Homo sapiens Q9UII6
Y2H Prey Pooling
25416956
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS06288 HOOK2 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus HOOK2 RGD RGD:1310171
Canis familiaris HOOK2 VGNC VGNC:41741
Felis catus HOOK2 VGNC VGNC:62833
Macaca mulatta HOOK2 VGNC VGNC:73425
Mus musculus HOOK2 MGD MGI:2181664
Bos taurus HOOK2 VGNC VGNC:29906
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