2. Gene
  3. DUSP13 - dual specificity phosphatase 13 Gene

DUSP13 - dual specificity phosphatase 13 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：双特异性磷酸酶 13

种属: Homo sapiens

同用名: BEDP; MDSP; TMDP; SKRP4; DUSP13A; DUSP13B

基因 ID: 51207 | 基因类型: protein coding

关于 DUSP13

Cytogenetic location: 10q22.2 Genomic coordinates (GRCh38): 10:75,094,434-75,109,191 (from NCBI)

This gene has 15 transcripts (splice variants), 242 orthologues and 30 paralogues. Biased expression in testis (RPKM 6.3), heart (RPKM 1.5) and 3 other tissues.

功能概要

蛋白酪氨酸磷酸酶超家族的成员与蛋白激酶协同调节细胞增殖和分化。根据去磷酸化的底物，该超家族分为两个家族。一个家族，双特异性磷酸酶 (DSP) 作用于磷酸酪氨酸和磷酸丝氨酸/苏氨酸残基。该基因通过使用非重叠的开放阅读框、交替剪接和假定的不同转录启动子来编码不同但相关的 DSP 蛋白。已发现来自该基因的不同蛋白质的表达具有组织特异性，并且这些蛋白质可能参与特定组织的出生后发育。在骨骼肌中发现了由上游 ORF 编码的蛋白质，而来自下游 ORF 的编码蛋白质仅在睾丸中发现。在小鼠中，发现了类似的表达模式。描述了多个选择性剪接的转录变体，但仅确定了其中一些的全长序列。[RefSeq 提供，2008 年 7 月]

Members of the protein-tyrosine Phosphatase superfamily cooperate with protein kinases to regulate cell proliferation and differentiation. This superfamily is separated into two families based on the substrate that is dephosphorylated. One family, the dual specificity phosphatases (DSPs) acts on both phosphotyrosine and phosphoserine/threonine residues. This gene encodes different but related DSP proteins through the use of non-overlapping open reading frames, alternate splicing, and presumed different transcription promoters. Expression of the distinct proteins from this gene has been found to be tissue specific and the proteins may be involved in postnatal development of specific tissues. A protein encoded by the upstream ORF was found in skeletal muscle, whereas the encoded protein from the downstream ORF was found only in testis. In mouse, a similar pattern of expression was found. Multiple alternatively spliced transcript variants were described, but the full-length sequence of only some were determined. [provided by RefSeq, Jul 2008]

DUSP13 基因产物(8)

mRNA Protein Name
NM_001007271.2 NP_001007272.1 dual specificity protein phosphatase 13 isoform 1
NM_001007272.2 NP_001007273.1 dual specificity protein phosphatase 13 isoform 2
NM_001007273.2 NP_001007274.1 dual specificity protein phosphatase 13 isoform 3 precursor
NM_001320842.2 NP_001307771.1 dual specificity protein phosphatase 13 isoform 3 precursor
NM_001320843.2 NP_001307772.1 dual specificity protein phosphatase 13 isoform 6
NM_001363514.2 NP_001350443.1 dual specificity protein phosphatase 13 isoform 9
NM_001412227.1 NP_001399156.1 dual specificity protein phosphatase 13 isoform 10
NM_016364.3 NP_057448.3 dual specificity protein phosphatase 13 isoform 6
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables phosphatase activity IDA
IDA: 通过直接分析推断
24531476 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
25416956 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in dephosphorylation IDA
IDA: 通过直接分析推断
24531476 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

DUSP13 蛋白结构

DSPc

DSPc: Dual specificity phosphatase, catalytic domain (45 - 180)

  • 0
  • 100
  • 188 a.a.
蛋白主名 其他名称

dual specificity protein phosphatase 13

Testis- and skeletal muscle-specific DUSP

DUSP13 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra DUSP13B Q9UII6 CARD9 Homo sapiens Q9H257-2
Y2H Prey Pooling
32296183
Intra DUSP13B Q9UII6 CARD9 Homo sapiens Q9H257-2
Y2H Array
32296183
Intra DUSP13B Q9UII6 SH2B2 Homo sapiens O14492-2
Y2H Prey Pooling
32296183
Intra DUSP13B Q9UII6 SH2B2 Homo sapiens O14492-2
Y2H Array
32296183
Intra DUSP13B Q9UII6 LMNA Homo sapiens P02545
Y2H Array
32296183
Intra DUSP13B Q9UII6 LMNA Homo sapiens P02545
Y2H Prey Pooling
25416956
Intra DUSP13B Q9UII6 LMNA Homo sapiens P02545
Y2H Prey Pooling
32296183
Intra DUSP13B Q9UII6 LMNA Homo sapiens P02545
Y2H Array
31515488
Intra DUSP13B Q9UII6 TRAF1 Homo sapiens Q13077
Y2H Array
32296183
Intra DUSP13B Q9UII6 TRAF1 Homo sapiens Q13077
Y2H Prey Pooling
32296183
Intra DUSP13B Q9UII6 ZRANB1 Homo sapiens Q9UGI0
Y2H Prey Pooling
32296183
Intra DUSP13B Q9UII6 ZRANB1 Homo sapiens Q9UGI0
Y2H Array
32296183
Intra DUSP13B Q9UII6 INCA1 Homo sapiens Q0VD86
Y2H Prey Pooling
32296183
Intra DUSP13B Q9UII6 INCA1 Homo sapiens Q0VD86
Y2H Array
32296183
Intra DUSP13B Q9UII6 HSF2BP Homo sapiens O75031
Y2H Prey Pooling
32296183
Intra DUSP13B Q9UII6 HSF2BP Homo sapiens O75031
Y2H Array
32296183
Intra DUSP13B Q9UII6 CALCOCO1 Homo sapiens Q9P1Z2
Y2H Prey Pooling
32296183
Intra DUSP13B Q9UII6 CALCOCO1 Homo sapiens Q9P1Z2
Y2H Array
32296183
Intra DUSP13B Q9UII6 CALCOCO1 Homo sapiens Q9P1Z2
Y2H Array
25416956
Intra DUSP13B Q9UII6 CARD9 Homo sapiens Q9H257
Y2H Array
25416956
Intra DUSP13B Q9UII6 PLEKHG4 Homo sapiens Q58EX7
Y2H Prey Pooling
32296183
Intra DUSP13B Q9UII6 PLEKHG4 Homo sapiens Q58EX7
Y2H Array
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Myoclonic Epilepsy Of Lafora

Lafora Disease

Epilepsy, Progressive Myoclonic 2b

EPM2

Melf

Epilepsy, Progressive Myoclonic 2a

Epm2a

Lafora'S Disease

Lafora Body Disease

Lbd

Epilepsy, Progressive Myoclonic, 2a

Lafora Progressive Myoclonic Epilepsy

Epilepsy Progressive Myoclonic 2

Lafora Body Disorder

Pme Type 2

Progressive Myoclonic Epilepsy Type 2

Progressive Myoclonus Epilepsy Type 2

Epilepsy, Progressive Myoclonic 2

Epm2b

Ld

Progressive Myoclonic Epilepsy 2

Progressive Myoclonic Epilepsy 2a

Progressive Myoclonic Epilepsy 2b

Progressive Myoclonic Epilepsy Lafora Type

Epilepsy, Myoclonic, Of Lafora
Juvenile Polyposis Syndrome

JPS

Juvenile Intestinal Polyposis

Jip

Pji

Juvenile Gastrointestinal Polyposis

Juvenile Polyposis

Polyposis, Juvenile Intestinal

Polyposis, Familial, Of Entire Gastrointestinal Tract

Polyposis Familial Of Entire Gastrointestinal Tract

Polyposis Juvenile Intestinal

Polyposis Syndrome, Juvenile
Dystonia 3, Torsion, X-Linked

X-Linked Dystonia-Parkinsonism

DYT3

Xdp

Lubag

Dystonia-Parkinsonism, X-Linked

Torsion Dystonia-Parkinsonism, Filipino Type

Dyt-Taf1

X-Linked Dystonia-Parkinsonism Syndrome

X-Linked Torsion Dystonia-Parkinsonism Syndrome

Dystonia Musculorum Deformans

X-Linked Dystonia-Parkinsonism/Lubag

Lubag Syndrome

Dystonia-3

Torsion Dystonia-Parkinsonism Filipino Type

X-Linked Torsion Dystonia 3

Dystonia, Torsion, X-Linked, Type 3
Bruxism

Sleep Bruxism

Sleep-Related Bruxism

Bruxism - Teeth Grinding

Grinding Teeth

Sleep Related Bruxism

Teeth Grinding

Sleep Related Teeth Grinding
Myopathy

Muscular Diseases

Myopathies
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS04054 DUSP13 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus DUSP13 RGD RGD:1359712
Mus musculus DUSP13 MGD MGI:1351599
Bos taurus DUSP13 VGNC VGNC:107306
Canis familiaris DUSP13 VGNC VGNC:106597
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