NRIP1 - nuclear receptor interacting protein 1 Gene

中文名称：核受体相互作用蛋白 1

种属: Homo sapiens

同用名: CAKUT3; RIP140

基因 ID: 8204 | 基因类型: protein coding

关于 NRIP1

Cytogenetic location: 21q11.2-q21.1 Genomic coordinates (GRCh38): 21:14,961,235-15,065,936 (from NCBI)

This gene has 7 transcripts (splice variants) and 197 orthologues. Ubiquitous expression in fat (RPKM 19.2), endometrium (RPKM 12.9) and 25 other tissues.

功能概要

核受体相互作用蛋白 1 (NRIP1) 是一种核蛋白，与核受体的激素依赖性激活域 AF2 特异性相互作用。这种蛋白质也称为 RIP140，可调节雌激素受体的转录活性。[RefSeq 提供，2008 年 7 月]

Nuclear receptor interacting protein 1 (NRIP1) is a nuclear protein that specifically interacts with the hormone-dependent activation domain AF2 of nuclear receptors. Also known as RIP140, this protein modulates transcriptional activity of the Estrogen Receptor. [provided by RefSeq, Jul 2008]

NRIP1 基因产物(1)

mRNA	Protein	Name
NM_003489.4	NP_003480.2	nuclear receptor-interacting protein 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: 通过直接分析推断	21628546	GOA
enables nuclear estrogen receptor binding	IPI IPI: 通过物理相互作用推断	7641693	GOA
enables nuclear glucocorticoid receptor binding	IPI IPI: 通过物理相互作用推断	10364267	GOA
enables nuclear receptor binding	IPI IPI: 通过物理相互作用推断	11518808	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	1266503	GOA
enables transcription coactivator activity	IDA IDA: 通过直接分析推断	7641693	GOA
enables transcription corepressor activity	IDA IDA: 通过直接分析推断	10364267	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in cellular response to estradiol stimulus	IDA IDA: 通过直接分析推断	15831516	GOA
involved in circadian regulation of gene expression	IMP IMP: 通过突变表型推断	21628546	GOA
involved in circadian rhythm	IEP IEP: 通过表达模式推断	21628546	GOA
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	10364267	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	7641693	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in chromatin	IDA IDA: 通过直接分析推断	15831516	GOA
located in nucleus	IDA IDA: 通过直接分析推断	7641693	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

蛋白主名

其他名称

nuclear receptor-interacting protein 1

nuclear factor RIP140

NRIP1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	NRIP1	P48552	RARA	Homo sapiens	P10276-2	Y2H Prey Pooling	25416956
Intra	NRIP1	P48552	GPRASP3	Homo sapiens	Q6PI77	Y2H Array	32296183
Intra	NRIP1	P48552	GPRASP3	Homo sapiens	Q6PI77	Y2H Prey Pooling	32296183
Intra	NRIP1	P48552	GPRASP3	Homo sapiens	Q6PI77	Validated Y2H	32296183
Intra	NRIP1	P48552	ESRRG	Homo sapiens	P62508-3	Validated Y2H	32296183
Intra	NRIP1	P48552	PKNOX2	Homo sapiens	Q96KN3	Y2H Prey Pooling	32296183
Intra	NRIP1	P48552	PKNOX2	Homo sapiens	Q96KN3	Validated Y2H	32296183
Intra	NRIP1	P48552	PKNOX2	Homo sapiens	Q96KN3	Y2H Array	32296183
Intra	NRIP1	P48552	ZNF366	Homo sapiens	Q8N895	Pull Down	17085477
Intra	NRIP1	P48552	ARPC3	Homo sapiens	O15145	Y2H Array	25416956
Intra	NRIP1	P48552	ARPC3	Homo sapiens	O15145	Y2H Prey Pooling	25416956
Intra	NRIP1	P48552	RARA	Homo sapiens	P10276	Y2H Prey Pooling	25416956
Intra	NRIP1	P48552	RARA	Homo sapiens	P10276	Y2H Array	25416956
Intra	NRIP1	P48552	GOLGA2	Homo sapiens	Q08379	Y2H Prey Pooling	32296183
Intra	NRIP1	P48552	GOLGA2	Homo sapiens	Q08379	Validated Y2H	32296183
Intra	NRIP1	P48552	GOLGA2	Homo sapiens	Q08379	Y2H Array	32296183
Intra	NRIP1	P48552	DNMT1	Homo sapiens	P26358	Pull Down	17972916
Intra	NRIP1	P48552	DNMT1	Homo sapiens	P26358	Anti Bait CoIP	17972916
Intra	NRIP1	P48552	CEP70	Homo sapiens	Q8NHQ1	Y2H Pooling	16189514
Intra	NRIP1	P48552	CEP70	Homo sapiens	Q8NHQ1	Y2H Fragment Pooling	35914814
Intra	NRIP1	P48552	LDOC1	Homo sapiens	O95751	Y2H Array	19060904
Intra	NRIP1	P48552	LDOC1	Homo sapiens	O95751	Y2H Pooling	16189514
Intra	NRIP1	P48552	LDOC1	Homo sapiens	O95751	Y2H Pooling	19060904
Intra	NRIP1	P48552	PRMT1	Homo sapiens	Q99873	Anti Bait CoIP	17053781
Intra	NRIP1	P48552	PRMT1	Homo sapiens	Q99873	Anti Tag CoIP	17053781
Intra	NRIP1	P48552	CTBP1	Homo sapiens	Q13363	Pull Down	17085477
Intra	NRIP1	P48552	FHL1	Homo sapiens	Q13642	Pull Down	19401155
Intra	NRIP1	P48552	FHL1	Homo sapiens	Q13642	Anti Tag CoIP	19401155

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Congenital Anomalies Of Kidney And Urinary Tract 3

CAKUT3

Cakut

Renal Or Urinary Tract Malformation	Congenital Anomalies Of Kidney And Urinary Tract
Congenital Anomaly Of Kidney And Urinary Tract	Congenital Anomalies Of The Kidney And Urinary Tract
Kidney And Urinary Tract, Anomalies, Congenital	Renal Hypodysplasia, Nonsyndromic, 1

Posterior Urethral Valves

Posterior Urethral Valve	Congenital Posterior Urethral Valves
Puv

Embryonal Carcinoma

Embryonal Neoplasm	Embryonal Cancer
Primary Extragonadal Embryonal Carcinoma	Embryo Neoplasm
Carcinoma Embryonal	Cancer Embryonal
Carcinoma, Embryonal	Extragonadal Embryonal Carcinoma
Cancer, Embryonal

Infertility

Down Syndrome

Trisomy 21	Complete Trisomy 21 Syndrome
Down'S Syndrome	Trisomy 21 Syndrome
Down'S Syndrome - Trisomy 21	Downs Syndrome
G Trisomy	47,Xx,+21
47,Xy,+21	Trisomy G
Down Syndrome, Susceptibility To	Chromosome 21 Trisomy
Trisomy 21 Nos	Abnormal Autosomes 21

Chronic Kidney Disease

Chronic Renal Disease	Chronic Kidney Failure
Ckd	Chronic Renal Failure
Kidney Failure, Chronic	Chronic Renal Failure Syndrome
Crf	Renal Failure - Chronic
Renal Failure Chronic	Chronic Kidney Diseases
Chronic Kidney Disease Stage 5	Ckd - [Chronic Kidney Disease]
Crf - [Chronic Renal Failure]	Chronic Kidney Impairment
Chronic Renal Impairment	Chronic Kidney Shutdown
Chronic Hypoxic Kidney Failure	Chronic Kidney Collapse
Chronic Renal Insufficiency	Chronic Kidney Toxaemia
Chronic Kidney Hypofunction	Chronic Renal Suppression
Chronic Renal Failure, Stage 5	Ckd - [Chronic Kidney Disease] Stage 5
End Stage Kidney Failure	End Stage Renal Failure
End Stage Kidney Disease	End Stage Renal Disease
End Stage Chronic Renal Failure	Esrf - [End Stage Renal Failure]
Esrd - [End Stage Renal Diseases]	Egfr - [Estimated Glomerular Filtration Rate] < 15 Ml/Min/1.73m²

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS09571	NRIP1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Canis familiaris	NRIP1	VGNC	VGNC:43969
Bos taurus	NRIP1	VGNC	VGNC:32263
Mus musculus	NRIP1	MGD	MGI:1315213
Rattus norvegicus	NRIP1	RGD	RGD:1311850
Felis catus	NRIP1	VGNC	VGNC:68567
Macaca mulatta	NRIP1	VGNC	VGNC:75529

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