1. Gene
  2. PKNOX2 - PBX/knotted 1 homeobox 2 Gene

PKNOX2 - PBX/knotted 1 homeobox 2 Gene

中文名称:PBX/结 1 同源盒 2

种属: Homo sapiens

同用名: PREP2

基因 ID: 63876 | 基因类型: protein coding

关于 PKNOX2

Cytogenetic location: 11q24.2 Genomic coordinates (GRCh38): 11:125,164,751-125,433,389 (from NCBI)

This gene has 14 transcripts (splice variants), 217 orthologues and 12 paralogues. Broad expression in thyroid (RPKM 4.8), ovary (RPKM 4.1) and 21 other tissues.

功能概要

同源域蛋白是序列特异性转录因子,它们共享一个高度保守的 DNA 结合域,并在细胞增殖、分化和死亡中发挥重要作用。 PKNOX2 属于 TALE (3-氨基酸环延伸) 类同源域蛋白,其特征是在同源域内的 α 螺旋 1 和 2 之间有 3-氨基酸延伸 (Imoto 等人,2001 [PubMed 11549286]) 。[由提供 OMIM,2009 年 10 月]

Homeodomain proteins are sequence-specific transcription factors that share a highly conserved DNA-binding domain and play fundamental roles in cell proliferation, differentiation, and death. PKNOX2 belongs to the TALE (3-amino acid loop extension) class of homeodomain proteins characterized by a 3-amino acid extension between alpha helices 1 and 2 within the homeodomain (Imoto et al., 2001 [PubMed 11549286]).[supplied by OMIM, Oct 2009]

PKNOX2 基因产物(19)

mRNA Protein Name
NM_001382323.2 NP_001369252.1 homeobox protein PKNOX2 isoform a
NM_001382324.1 NP_001369253.1 homeobox protein PKNOX2 isoform a
NM_001382325.1 NP_001369254.1 homeobox protein PKNOX2 isoform a
NM_001382326.1 NP_001369255.1 homeobox protein PKNOX2 isoform a
NM_001382327.1 NP_001369256.1 homeobox protein PKNOX2 isoform a
NM_001382328.1 NP_001369257.1 homeobox protein PKNOX2 isoform a
NM_001382329.1 NP_001369258.1 homeobox protein PKNOX2 isoform b
NM_001382330.1 NP_001369259.1 homeobox protein PKNOX2 isoform b
NM_001382331.1 NP_001369260.1 homeobox protein PKNOX2 isoform b
NM_001382332.1 NP_001369261.1 homeobox protein PKNOX2 isoform b
NM_001382333.1 NP_001369262.1 homeobox protein PKNOX2 isoform b
NM_001382334.1 NP_001369263.1 homeobox protein PKNOX2 isoform c
NM_001382335.1 NP_001369264.1 homeobox protein PKNOX2 isoform c
NM_001382336.1 NP_001369265.1 homeobox protein PKNOX2 isoform d
NM_001382337.1 NP_001369266.1 homeobox protein PKNOX2 isoform d
NM_001382338.1 NP_001369267.1 homeobox protein PKNOX2 isoform d
NM_001382339.1 NP_001369268.1 homeobox protein PKNOX2 isoform e
NM_001382340.1 NP_001369269.1 homeobox protein PKNOX2 isoform f
NM_001382341.1 NP_001369270.1 homeobox protein PKNOX2 isoform g
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
20211142 GOA
enables sequence-specific double-stranded DNA binding IDA
IDA: 通过直接分析推断
28473536 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

PKNOX2 蛋白结构

Homeobox_KN

Homeobox_KN: Homeobox KN domain (306 - 345)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 472 a.a.
蛋白主名 其他名称

homeobox protein PKNOX2

PBX/knotted homeobox 2

PKNOX2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
PKNOX2 Q96KN3 PBX4 Homo sapiens Q9BYU1 32296183
种属内
PKNOX2 Q96KN3 CTTNBP2NL Homo sapiens Q9P2B4 32296183
种属内
PKNOX2 Q96KN3 DDA1 Homo sapiens Q9BW61 32296183
种属内
PKNOX2 Q96KN3 NUP58 Homo sapiens Q9BVL2 32296183
种属内
PKNOX2 Q96KN3 PBX1 Homo sapiens P40424 33961781
种属内
PKNOX2 Q96KN3 TSG101 Homo sapiens Q99816 32296183
种属内
PKNOX2 Q96KN3 TRIB3 Homo sapiens Q96RU7 32296183
种属内
PKNOX2 Q96KN3 PAAT Homo sapiens Q9H8K7 32296183
种属内
PKNOX2 Q96KN3 ENKD1 Homo sapiens Q9H0I2 32296183
种属内
PKNOX2 Q96KN3 CSTF2T Homo sapiens Q9H0L4 32296183
种属内
PKNOX2 Q96KN3 PICK1 Homo sapiens Q9NRD5 32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Megalencephalic Leukoencephalopathy With Subcortical Cysts 2a

MLC2A

Leukoencephalopathy, Megalencephalic, With Subcortical Cysts, 2a

Leukoencephalopathy, Megalencephalic, With Subcortical Cysts, Type 2a

Brugada Syndrome 2

BRGDA2

Brugada Syndrome, Type 2

Megalencephalic Leukoencephalopathy With Subcortical Cysts 2b

Megalencephalic Leukoencephalopathy With Subcortical Cysts 2b, Remitting, With Or Without Mental Retardation

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Canis familiaris PKNOX2 VGNC VGNC:44615
Felis catus PKNOX2 VGNC VGNC:64196
Bos taurus PKNOX2 VGNC VGNC:32949
Rattus norvegicus PKNOX2 RGD RGD:1590611
Macaca mulatta PKNOX2 VGNC VGNC:76037
Mus musculus PKNOX2 MGD MGI:2445415