2. Gene
  3. LCORL - ligand dependent nuclear receptor corepressor like Gene

LCORL - ligand dependent nuclear receptor corepressor like Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：配体依赖性核受体辅阻遏物

种属: Homo sapiens

同用名: MLR1

基因 ID: 254251 | 基因类型: protein coding

关于 LCORL

Cytogenetic location: 4p15.31 Genomic coordinates (GRCh38): 4:17,841,187-18,021,875 (from NCBI)

This gene has 15 transcripts (splice variants), 96 orthologues and 1 paralogue. Ubiquitous expression in testis (RPKM 2.1), small intestine (RPKM 1.8) and 25 other tissues.

功能概要

该基因编码的转录因子似乎在精子发生中发挥作用。该基因的多态性与骨骼尺寸和成年身高的测量有关。可变剪接导致多个转录本变体。[RefSeq 提供，2009 年 10 月]

This gene encodes a transcription factor that appears to function in spermatogenesis. Polymorphisms in this gene are associated with measures of skeletal frame size and adult height. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]

LCORL 基因产物(10)

mRNA Protein Name
NM_001166139.2 NP_001159611.1 ligand-dependent nuclear receptor corepressor-like protein isoform 1
NM_001365658.1 NP_001352587.1 ligand-dependent nuclear receptor corepressor-like protein isoform 3
NM_001365659.1 NP_001352588.1 ligand-dependent nuclear receptor corepressor-like protein isoform 3
NM_001365660.1 NP_001352589.1 ligand-dependent nuclear receptor corepressor-like protein isoform 4
NM_001365661.1 NP_001352590.1 ligand-dependent nuclear receptor corepressor-like protein isoform 5
NM_001365662.1 NP_001352591.1 ligand-dependent nuclear receptor corepressor-like protein isoform 6
NM_001365663.1 NP_001352592.1 ligand-dependent nuclear receptor corepressor-like protein isoform 7
NM_001365665.1 NP_001352594.1 ligand-dependent nuclear receptor corepressor-like protein isoform 8
NM_001394446.1 NP_001381375.1 ligand-dependent nuclear receptor corepressor-like protein isoform 9
NM_153686.8 NP_710153.2 ligand-dependent nuclear receptor corepressor-like protein isoform 2
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables histone methyltransferase binding IPI
IPI: 通过物理相互作用推断
29628311 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
21900206 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

LCORL 蛋白结构

HTH_psq

HTH_psq: helix-turn-helix, Psq domain (527 - 570)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 602 a.a.
蛋白主名 其他名称

ligand-dependent nuclear receptor corepressor-like protein

LCOR-like protein

LCORL 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
LCORL Q8N3X6 MAGEA6 Homo sapiens P43360
Y2H Array
25416956
种属内
LCORL Q8N3X6 MAGEA6 Homo sapiens P43360
Y2H Prey Pooling
25416956
种属内
LCORL Q8N3X6 CTBP1 Homo sapiens Q13363
TAP
24981860
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Croup

Acute Obstructive Laryngitis

Laryngotracheobronchitis

Acute Laryngotracheobronchitis

Croup Syndrome

Acute Laryngitis With Obstruction

Obstructive Laryngitis

Obstructive Laryngitis Nos

Obstructive Laryngotracheitis Nos
Acromesomelic Dysplasia 2b

Fibular Hypoplasia And Complex Brachydactyly

Du Pan Syndrome

AMD2B

Dupans

Acromesomelic Dysplasia-2b

Fibular Aplasia-Complex Brachydactyly Syndrome
Acromesomelic Dysplasia

Acromesomelic Dwarfism

Dysplasia, Acromesomelic

Acromesomelic Dysplasia Hunter-Thompson Type
Osteochondrosis

Osteochondritis

Apophysitis

Epiphysitis

Osteochondritis Juvenilis

Epiphyseal Necrosis

Juvenile Osteochondrosis Of Tibial Tubercle
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS07562 LCORL Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus LCORL RGD RGD:1561241
Felis catus LCORL VGNC VGNC:78520
Mus musculus LCORL MGD MGI:2651932
Canis familiaris LCORL VGNC VGNC:59023
Macaca mulatta LCORL VGNC VGNC:106624
Bos taurus LCORL VGNC VGNC:30816
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