2. Gene
  3. PCGF3 - polycomb group ring finger 3 Gene

PCGF3 - polycomb group ring finger 3 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：Polycomb 组无名指 3

种属: Homo sapiens

同用名: RNF3; DONG1; RNF3A

基因 ID: 10336 | 基因类型: protein coding

关于 PCGF3

Cytogenetic location: 4p16.3 Genomic coordinates (GRCh38): 4:705,832-770,089 (from NCBI)

This gene has 13 transcripts (splice variants), 212 orthologues and 7 paralogues. Ubiquitous expression in skin (RPKM 24.1), endometrium (RPKM 13.1) and 25 other tissues.

功能概要

该基因编码的蛋白质包含一个 C3HC4 型环指，这是已知参与蛋白质-蛋白质相互作用的基序。这种蛋白质的具体功能尚未确定。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene contains a C3HC4 type RING finger, which is a motif known to be involved in protein-protein interactions. The specific function of this protein has not yet been determined. [provided by RefSeq, Jul 2008]

PCGF3 基因产物(9)

mRNA Protein Name
NM_001317836.3 NP_001304765.1 polycomb group RING finger protein 3 isoform a
NM_001395245.1 NP_001382174.1 polycomb group RING finger protein 3 isoform a
NM_001395246.1 NP_001382175.1 polycomb group RING finger protein 3 isoform a
NM_001395247.1 NP_001382176.1 polycomb group RING finger protein 3 isoform a
NM_001395248.1 NP_001382177.1 polycomb group RING finger protein 3 isoform a
NM_001395249.1 NP_001382178.1 polycomb group RING finger protein 3 isoform a
NM_001395250.1 NP_001382179.1 polycomb group RING finger protein 3 isoform b
NM_001395251.1 NP_001382180.1 polycomb group RING finger protein 3 isoform b
NM_006315.7 NP_006306.2 polycomb group RING finger protein 3 isoform a
基因本体论
  • 分子功能
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
21282530 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of PcG protein complex IDA
IDA: 通过直接分析推断
21282530 GOA
located in nucleus IDA
IDA: 通过直接分析推断
21282530 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PCGF3 蛋白结构

zf-C3HC4

zf-C3HC4: Zinc finger, C3HC4 type (RING finger) (17 - 55)

  • 0
  • 100
  • 200
  • 242 a.a.
蛋白主名 其他名称

polycomb group RING finger protein 3

RING finger protein 3A

PCGF3 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
PCGF3 Q3KNV8 CBX7 Homo sapiens O95931
Pull Down
21282530
种属内
PCGF3 Q3KNV8 CBX6 Homo sapiens O95503
Pull Down
21282530
种属内
PCGF3 Q3KNV8 CBX8 Homo sapiens Q9HC52
Pull Down
21282530
种属内
PCGF3 Q3KNV8 PHC2 Homo sapiens Q8IXK0
Y2H Prey Pooling
25416956
种属内
PCGF3 Q3KNV8 RNF2 Homo sapiens Q99496
TAP
27705803
种属内
PCGF3 Q3KNV8 RNF2 Homo sapiens Q99496
Y2H Array
22493164
种属内
PCGF3 Q3KNV8 RING1 Homo sapiens Q06587
TAP
27705803
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Shukla-Vernon Syndrome

SHUVER
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS10147 PCGF3 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus PCGF3 RGD RGD:1311479
Bos taurus PCGF3 VGNC VGNC:97295
Canis familiaris PCGF3 VGNC VGNC:44302
Mus musculus PCGF3 MGD MGI:1916837
Felis catus PCGF3 VGNC VGNC:64067
Macaca mulatta PCGF3 VGNC VGNC:75593
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