2. Gene
  3. UBE2E2 - ubiquitin conjugating enzyme E2 E2 Gene

UBE2E2 - ubiquitin conjugating enzyme E2 E2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：泛素结合酶 E2 E2

种属: Homo sapiens

同用名: UBCH8

基因 ID: 7325 | 基因类型: protein coding

关于 UBE2E2

Cytogenetic location: 3p24.3 Genomic coordinates (GRCh38): 3:23,203,098-23,591,925 (from NCBI)

This gene has 7 transcripts (splice variants), 139 orthologues and 12 paralogues. Ubiquitous expression in brain (RPKM 1.5), fat (RPKM 1.2) and 25 other tissues.

功能概要

启用 ISG15 转移酶活性和泛素结合酶活性。通过小蛋白缀合参与蛋白质修饰。在细胞对 DNA 损伤刺激的反应和有丝分裂细胞周期的 G1/S 转换的正调节作用的上游或细胞内起作用。预计活跃于核心。 [由基因组资源联盟提供，2022 年 4 月]

Enables ISG15 transferase activity and ubiquitin conjugating Enzyme activity. Involved in protein modification by small protein conjugation. Acts upstream of or within cellular response to DNA damage stimulus and positive regulation of G1/S transition of mitotic cell cycle. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

UBE2E2 基因产物(5)

mRNA Protein Name
NM_001370225.1 NP_001357154.1 ubiquitin-conjugating enzyme E2 E2 isoform 1
NM_001370226.1 NP_001357155.1 ubiquitin-conjugating enzyme E2 E2 isoform 2
NM_001370227.1 NP_001357156.1 ubiquitin-conjugating enzyme E2 E2 isoform 3
NM_001370228.1 NP_001357157.1 ubiquitin-conjugating enzyme E2 E2 isoform 3
NM_152653.4 NP_689866.1 ubiquitin-conjugating enzyme E2 E2 isoform 1
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables ISG15 transferase activity IDA
IDA: 通过直接分析推断
16428300 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
17460044 GOA
enables ubiquitin conjugating enzyme activity IDA
IDA: 通过直接分析推断
9371400 GOA
enables ubiquitin-protein transferase activity IDA
IDA: 通过直接分析推断
20061386 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within DNA damage response IMP
IMP: 通过突变表型推断
21628527 GOA
involved in ISG15-protein conjugation IDA
IDA: 通过直接分析推断
16428300 GOA
acts upstream of or within positive regulation of G1/S transition of mitotic cell cycle IGI
IGI: 通过遗传相互作用推断
21628527 GOA
involved in protein K11-linked ubiquitination IDA
IDA: 通过直接分析推断
20061386 GOA
involved in protein K48-linked ubiquitination IDA
IDA: 通过直接分析推断
20061386 GOA
involved in protein K63-linked ubiquitination IDA
IDA: 通过直接分析推断
20061386 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

UBE2E2 蛋白结构

UQ_con

UQ_con: Ubiquitin-conjugating enzyme (59 - 195)

  • 0
  • 100
  • 201 a.a.
蛋白主名 其他名称

ubiquitin-conjugating enzyme E2 E2

E2 ubiquitin-conjugating enzyme E2

UBE2E2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra UBE2E2 Q96LR5 MID2 Homo sapiens Q9UJV3-2
Y2H Prey Pooling
25416956
Intra UBE2E2 Q96LR5 MID2 Homo sapiens Q9UJV3-2
Validated Y2H
25416956
Intra UBE2E2 Q96LR5 MID2 Homo sapiens Q9UJV3-2
Y2H Prey Pooling
32296183
Intra UBE2E2 Q96LR5 MID2 Homo sapiens Q9UJV3-2
Validated Y2H
32296183
Intra UBE2E2 Q96LR5 MID2 Homo sapiens Q9UJV3-2
Y2H Array
25416956
Intra UBE2E2 Q96LR5 MID2 Homo sapiens Q9UJV3-2
Y2H Array
32296183
Intra UBE2E2 Q96LR5 FAM9B Homo sapiens Q8IZU0
Validated Y2H
25416956
Intra UBE2E2 Q96LR5 FAM9B Homo sapiens Q8IZU0
Y2H Array
25416956
Intra UBE2E2 Q96LR5 FAM9B Homo sapiens Q8IZU0
Y2H Prey Pooling
25416956
Intra UBE2E2 Q96LR5 OTUB1 Homo sapiens Q96FW1
Anti Tag CoIP
33961781
Intra UBE2E2 Q96LR5 OTUB1 Homo sapiens Q96FW1
Anti Tag CoIP
28514442
Intra UBE2E2 Q96LR5 TRIM39 Homo sapiens Q9HCM9-2
Y2H Array
32296183
Intra UBE2E2 Q96LR5 TRIM39 Homo sapiens Q9HCM9-2
Validated Y2H
32296183
Intra UBE2E2 Q96LR5 TRIM39 Homo sapiens Q9HCM9-2
Y2H Prey Pooling
32296183
Intra UBE2E2 Q96LR5 CHFR Homo sapiens Q96EP1-2
Y2H Array
32296183
Intra UBE2E2 Q96LR5 CHFR Homo sapiens Q96EP1-2
Y2H Prey Pooling
32296183
Intra UBE2E2 Q96LR5 PGPEP1 Homo sapiens Q9NXJ5-2
Validated Y2H
32296183
Intra UBE2E2 Q96LR5 PGPEP1 Homo sapiens Q9NXJ5-2
Y2H Array
32296183
Intra UBE2E2 Q96LR5 PGPEP1 Homo sapiens Q9NXJ5-2
Y2H Prey Pooling
32296183
Intra UBE2E2 Q96LR5 RNF25 Homo sapiens Q96BH1
Anti Tag CoIP
33961781
Intra UBE2E2 Q96LR5 RNF25 Homo sapiens Q96BH1
Anti Tag CoIP
28514442
Intra UBE2E2 Q96LR5 RNF25 Homo sapiens Q96BH1
Y2H Array
19549727
Intra UBE2E2 Q96LR5 RNF115 Homo sapiens Q9Y4L5
Y2H Prey Pooling
32296183
Intra UBE2E2 Q96LR5 RNF115 Homo sapiens Q9Y4L5
Validated Y2H
32296183
Intra UBE2E2 Q96LR5 RNF115 Homo sapiens Q9Y4L5
Y2H Array
32296183
Intra UBE2E2 Q96LR5 TRIM3 Homo sapiens O75382
Y2H Prey Pooling
32296183
Intra UBE2E2 Q96LR5 TRIM3 Homo sapiens O75382
Y2H Array
32296183
Intra UBE2E2 Q96LR5 RNF125 Homo sapiens Q96EQ8
Y2H Array
19549727
Intra UBE2E2 Q96LR5 RNF185 Homo sapiens Q96GF1
Y2H Prey Pooling
32296183
Intra UBE2E2 Q96LR5 RNF185 Homo sapiens Q96GF1
Y2H Array
32296183
Intra UBE2E2 Q96LR5 MID1 Homo sapiens O15344
Y2H Array
31515488
Intra UBE2E2 Q96LR5 MID1 Homo sapiens O15344
Y2H Prey Pooling
32296183
Intra UBE2E2 Q96LR5 MID1 Homo sapiens O15344
Y2H Prey Pooling
25416956
Intra UBE2E2 Q96LR5 MID1 Homo sapiens O15344
Y2H Array
25416956
Intra UBE2E2 Q96LR5 MID1 Homo sapiens O15344
Y2H Array
32296183
Intra UBE2E2 Q96LR5 MID1 Homo sapiens O15344
Y2H
21516116
Intra UBE2E2 Q96LR5 ARRDC3 Homo sapiens Q96B67
Y2H Prey Pooling
25416956
Intra UBE2E2 Q96LR5 ARRDC3 Homo sapiens Q96B67
Y2H Prey Pooling
32296183
Intra UBE2E2 Q96LR5 ARRDC3 Homo sapiens Q96B67
Y2H Array
32296183
Intra UBE2E2 Q96LR5 RNF5 Homo sapiens Q99942
Y2H Array
19549727
Intra UBE2E2 Q96LR5 RNF5 Homo sapiens Q99942
Y2H
19549727
Intra UBE2E2 Q96LR5 RNF5 Homo sapiens Q99942
Validated Y2H
32296183
Intra UBE2E2 Q96LR5 RNF5 Homo sapiens Q99942
Y2H Array
32296183
Intra UBE2E2 Q96LR5 RNF5 Homo sapiens Q99942
Y2H Prey Pooling
32296183
Intra UBE2E2 Q96LR5 CUEDC1 Homo sapiens Q9NWM3
Y2H Prey Pooling
32296183
Intra UBE2E2 Q96LR5 CUEDC1 Homo sapiens Q9NWM3
Y2H Array
32296183
Intra UBE2E2 Q96LR5 CUEDC1 Homo sapiens Q9NWM3
Validated Y2H
32296183
Intra UBE2E2 Q96LR5 RNF2 Homo sapiens Q99496
Y2H Prey Pooling
32296183
Intra UBE2E2 Q96LR5 RNF2 Homo sapiens Q99496
Validated Y2H
32296183
Intra UBE2E2 Q96LR5 RNF2 Homo sapiens Q99496
Y2H Array
32296183
Intra UBE2E2 Q96LR5 DAZAP2 Homo sapiens Q15038
Y2H Array
25416956
Intra UBE2E2 Q96LR5 TRIM39 Homo sapiens Q9HCM9
Y2H
21516116
Intra UBE2E2 Q96LR5 TRIM39 Homo sapiens Q9HCM9
Y2H Array
31515488
Intra UBE2E2 Q96LR5 WWP2 Homo sapiens O00308
Y2H Prey Pooling
32296183
Intra UBE2E2 Q96LR5 WWP2 Homo sapiens O00308
Y2H Array
32296183
Intra UBE2E2 Q96LR5 DZIP3 Homo sapiens Q86Y13
Y2H Array
29892012
Intra UBE2E2 Q96LR5 DZIP3 Homo sapiens Q86Y13
Y2H
21516116
Intra UBE2E2 Q96LR5 DZIP3 Homo sapiens Q86Y13
Y2H Array
31515488
Intra UBE2E2 Q96LR5 TRIM50 Homo sapiens Q86XT4
Y2H Prey Pooling
32296183
Intra UBE2E2 Q96LR5 TRIM50 Homo sapiens Q86XT4
Y2H Array
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Immunodeficiency 38 With Basal Ganglia Calcification

Mendelian Susceptibility To Mycobacterial Diseases Due To Complete Isg15 Deficiency

IMD38

Immunodeficiency 38, Mycobacteriosis, Autosomal Recessive

Immunodeficiency 38

Isg15 Deficiency, Autosomal Recessive

Immunodeficiency 38, With Basal Ganglia Calcification

Autosomal Recessive Isg15 Deficiency

Msmd Due To Complete Isg15 Deficiency

Immunodeficiency, Type 38
Intracranial Arteriosclerosis
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS15343 UBE2E2 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta UBE2E2 VGNC VGNC:78415
Rattus norvegicus UBE2E2 RGD RGD:1305644
Mus musculus UBE2E2 MGD MGI:2384997
Bos taurus UBE2E2 VGNC VGNC:107010
Others UBE2E2 NCBI
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