TRIM3 - tripartite motif containing 3 Gene

中文名称：含三方基序 3

种属: Homo sapiens

同用名: BERP; HAC1; RNF22; RNF97

关于 TRIM3

功能概要

该基因编码的蛋白质是三联基序 (TRIM) 家族的成员，也称为 RING 指蛋白的“RING-B-box-coiled-coil” (RBCC) 亚组。 TRIM 基序包括三个锌结合域、一个 RING、一个 B-box 类型 1 和一个 B-box 类型 2，以及一个卷曲螺旋区域。这种蛋白质定位于细胞质丝。它类似于大鼠蛋白，它是肌球蛋白 V 尾部结构域的特定伙伴，肌球蛋白 V 是一类参与细胞器靶向运输的肌球蛋白。大鼠蛋白还可以与 alpha-actinin-4 相互作用。因此表明这种人类蛋白质可能在肌球蛋白 V 介导的货物运输中发挥作用。已经鉴定出编码相同亚型的可变剪接转录本变体。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene is a member of the tripartite motif (TRIM) family, also called the 'RING-B-box-coiled-coil' (RBCC) subgroup of RING finger proteins. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to cytoplasmic filaments. It is similar to a rat protein which is a specific partner for the tail domain of Myosin V, a class of myosins which are involved in the targeted transport of organelles. The rat protein can also interact with alpha-actinin-4. Thus it is suggested that this human protein may play a role in Myosin V-mediated cargo transport. Alternatively spliced transcript variants encoding the same isoform have been identified. [provided by RefSeq, Jul 2008]