1. Gene
  2. CSNK1D - casein kinase 1 delta Gene

CSNK1D - casein kinase 1 delta Gene

中文名称:酪蛋白激酶 1 δ

种属: Homo sapiens

同用名: ASPS; CKId; HCKID; FASPS2; CKIdelta; CKI-delta

基因 ID: 1453 | 基因类型: protein coding

关于 CSNK1D

Cytogenetic location: 17q25.3 Genomic coordinates (GRCh38): 17:82,239,019-82,273,750 (from NCBI)

This gene has 26 transcripts (splice variants), 264 orthologues, 12 paralogues and is associated with 2 phenotypes. Ubiquitous expression in spleen (RPKM 17.2), prostate (RPKM 17.2) and 25 other tissues.

功能概要

该基因是酪蛋白激酶 I (CKI) 基因家族的成员,其成员参与细胞质和细胞核过程的控制,包括 DNA 复制和修复。编码的蛋白质还可能参与细胞凋亡、昼夜节律、微管动力学、染色体分离和 p53 介导的生长效应的调节。编码的蛋白质与小鼠和大鼠 CK1 delta 同系物高度相似。已发现该基因的三个转录变体编码不同的亚型。[RefSeq 提供,2014 年 2 月]

This gene is a member of the Casein Kinase I (CKI) gene family whose members have been implicated in the control of cytoplasmic and nuclear processes, including DNA replication and repair. The encoded protein may also be involved in the regulation of Apoptosis, circadian rhythm, microtubule dynamics, chromosome segregation, and p53-mediated effects on growth. The encoded protein is highly similar to the mouse and rat CK1 delta homologs. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2014]

CSNK1D 基因产物(3)

mRNA Protein Name
NM_001363749.2 NP_001350678.1 casein kinase I isoform delta isoform 3
NM_001893.6 NP_001884.2 casein kinase I isoform delta isoform 1
NM_139062.4 NP_620693.1 casein kinase I isoform delta isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
16189514 GOA
enables protein kinase activity IDA
IDA: 通过直接分析推断
16618118 GOA
enables protein kinase activity IMP
IMP: 通过突变表型推断
19591487 GOA
enables protein serine kinase activity IDA
IDA: 通过直接分析推断
12270943 GOA
enables protein serine kinase activity IMP
IMP: 通过突变表型推断
19043076 GOA
enables protein serine/threonine kinase activity IDA
IDA: 通过直接分析推断
10606744 GOA
enables tau-protein kinase activity IDA
IDA: 通过直接分析推断
16618118 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within Golgi organization IMP
IMP: 通过突变表型推断
24648492 GOA
acts upstream of or within microtubule nucleation IMP
IMP: 通过突变表型推断
24648492 GOA
acts upstream of or within non-motile cilium assembly IMP
IMP: 通过突变表型推断
24648492 GOA
involved in positive regulation of canonical Wnt signaling pathway IMP
IMP: 通过突变表型推断
20412773 GOA
involved in positive regulation of protein phosphorylation IMP
IMP: 通过突变表型推断
20412773 GOA
acts upstream of or within protein localization to Golgi apparatus IMP
IMP: 通过突变表型推断
24648492 GOA
acts upstream of or within protein localization to centrosome IMP
IMP: 通过突变表型推断
24648492 GOA
acts upstream of or within protein localization to cilium IMP
IMP: 通过突变表型推断
24648492 GOA
involved in protein phosphorylation IDA
IDA: 通过直接分析推断
16618118 GOA
involved in spindle assembly IDA
IDA: 通过直接分析推断
10826492 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in Golgi apparatus IDA
IDA: 通过直接分析推断
10826492 GOA
located in centrosome IDA
IDA: 通过直接分析推断
21399614 GOA
located in ciliary basal body IDA
IDA: 通过直接分析推断
29257953 GOA
located in perinuclear region of cytoplasm IDA
IDA: 通过直接分析推断
16027726 GOA
located in plasma membrane IDA
IDA: 通过直接分析推断
16027726 GOA
located in spindle IDA
IDA: 通过直接分析推断
10826492 GOA
located in spindle microtubule IDA
IDA: 通过直接分析推断
10826492 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

CSNK1D 蛋白结构

Pkinase

Pkinase: Protein kinase domain (9 - 246)

  • 0
  • 100
  • 200
  • 300
  • 415 a.a.
蛋白主名 其他名称

casein kinase I isoform delta

casein kinase I

tau-protein kinase CSNK1D

CSNK1D 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
CSNK1D P48730 DRICH1 Homo sapiens Q6PGQ1
Validated Y2H
32296183
种属内
CSNK1D P48730 DRICH1 Homo sapiens Q6PGQ1
Y2H Array
32296183
种属内
CSNK1D P48730 GAPVD1 Homo sapiens Q14C86
Anti Tag CoIP
33961781
种属内
CSNK1D P48730 GAPVD1 Homo sapiens Q14C86
Pull Down
32707033
种属内
CSNK1D P48730 GAPVD1 Homo sapiens Q14C86
Anti Tag CoIP
35271311
种属内
CSNK1D P48730 PER2 Homo sapiens O15055
Y2H Prey Pooling
32296183
种属内
CSNK1D P48730 PER2 Homo sapiens O15055
Anti Tag CoIP
33961781
种属内
CSNK1D P48730 PER2 Homo sapiens O15055
Y2H Array
32296183
种属内
CSNK1D P48730 PER2 Homo sapiens O15055
Protein Kinase Assay
21179498
种属内
CSNK1D P48730 CCDC14 Homo sapiens Q49A88-3
Validated Y2H
32296183
种属内
CSNK1D P48730 CCDC14 Homo sapiens Q49A88-3
Y2H Array
32296183
种属内
CSNK1D P48730 CCDC14 Homo sapiens Q49A88-3
Y2H Prey Pooling
32296183
种属内
CSNK1D P48730 IKZF4 Homo sapiens Q9H2S9
Y2H Array
32296183
种属内
CSNK1D P48730 IKZF4 Homo sapiens Q9H2S9
Y2H Prey Pooling
32296183
种属内
CSNK1D P48730 IKZF4 Homo sapiens Q9H2S9
Validated Y2H
32296183
种属内
CSNK1D P48730 TRIM3 Homo sapiens O75382
Y2H Array
32296183
种属内
CSNK1D P48730 TRIM3 Homo sapiens O75382
Y2H Prey Pooling
32296183
种属内
CSNK1D P48730 MDM2 Homo sapiens Q00987
Pull Down
20708156
种属内
CSNK1D P48730 MDM2 Homo sapiens Q00987
Anti Tag CoIP
20708156
种属内
CSNK1D P48730 MDM2 Homo sapiens Q00987
Anti Bait CoIP
20708156
种属内
CSNK1D P48730 ZNF618 Homo sapiens Q5T7W0
Y2H Array
32296183
种属内
CSNK1D P48730 ZNF618 Homo sapiens Q5T7W0
Anti Tag CoIP
33961781
种属内
CSNK1D P48730 ZNF618 Homo sapiens Q5T7W0
Validated Y2H
32296183
种属内
CSNK1D P48730 ZNF618 Homo sapiens Q5T7W0
Y2H Prey Pooling
32296183
种属间
CSNK1D P48730 Dvl2 Mus musculus Q60838
Protein Kinase Assay
22609948
种属内
CSNK1D P48730 TRIM9 Homo sapiens Q9C026
Validated Y2H
25416956
种属内
CSNK1D P48730 TRIM9 Homo sapiens Q9C026
Y2H Prey Pooling
25416956
种属内
CSNK1D P48730 TRIM9 Homo sapiens Q9C026
Y2H Array
25416956
种属内
CSNK1D P48730 DVL3 Homo sapiens Q92997
Y2H Prey Pooling
25416956
种属内
CSNK1D P48730 DVL3 Homo sapiens Q92997
Y2H Pooling
16189514
种属内
CSNK1D P48730 DVL3 Homo sapiens Q92997
Validated Y2H
25416956
种属内
CSNK1D P48730 LZTS2 Homo sapiens Q9BRK4
Y2H Array
32296183
种属内
CSNK1D P48730 LZTS2 Homo sapiens Q9BRK4
Y2H Prey Pooling
32296183
种属内
CSNK1D P48730 LZTS2 Homo sapiens Q9BRK4
Validated Y2H
32296183
种属内
CSNK1D P48730 LURAP1 Homo sapiens Q96LR2
Validated Y2H
25416956
种属内
CSNK1D P48730 LURAP1 Homo sapiens Q96LR2
Anti Tag CoIP
25416956
种属内
CSNK1D P48730 LURAP1 Homo sapiens Q96LR2
Y2H Prey Pooling
25416956
种属内
CSNK1D P48730 PAK5 Homo sapiens Q9P286
Validated Y2H
32296183
种属内
CSNK1D P48730 PAK5 Homo sapiens Q9P286
Y2H Array
32296183
种属内
CSNK1D P48730 PAK5 Homo sapiens Q9P286
Y2H Prey Pooling
32296183
种属内
CSNK1D P48730 ZBTB8A Homo sapiens Q96BR9
Y2H Prey Pooling
32296183
种属内
CSNK1D P48730 ZBTB8A Homo sapiens Q96BR9
Validated Y2H
32296183
种属内
CSNK1D P48730 ZBTB8A Homo sapiens Q96BR9
Y2H Array
32296183
种属内
CSNK1D P48730 EVI5 Homo sapiens O60447
Y2H Array
32296183
种属内
CSNK1D P48730 EVI5 Homo sapiens O60447
Y2H Prey Pooling
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Advanced Sleep Phase Syndrome, Familial, 2

Advanced Sleep Phase Syndrome 2

FASPS2

Advanced Sleep-Phase Syndrome, Familial, 2

Familial Advanced Sleep Phase Syndrome 2

Sleep Phase Syndrome, Advanced, Familial, Type 2

Advanced Sleep Phase Syndrome

Fasps

Familial Advanced Sleep-Phase Syndrome

Advanced Sleep Phase Syndrome, Familial

Familial Advanced Sleep Phase Syndrome

Sleep Phase Syndrome, Advanced, Familial

Advanced Sleep-Phase Syndrome, Familial

Migraine, Familial Hemiplegic, 1

FHM1

Mhp1

Fhm

Familial Hemiplegic Migraine 1

Migraine, Familial Hemiplegic, 1, With Progressive Cerebellar Ataxia

Familial Hemiplegic Migraine1 With Progressive Cerebellar Ataxia

Migraine Familial Hemiplegic With Progressive Cerebellar Ataxia

Migraine, Hemiplegic, Familial, Type 1

Hemiplegic Migraine, Familial Type 1

Delayed Sleep Phase Disorder

Delayed Sleep Phase Syndrome

Delayed Sleep Phase Syndrome, Susceptibility To

DSPD

Delayed Sleep Phase Disorder, Susceptibility To

DSPS

Sleep Phase, Delayed, Disorder

Sleep Phase Syndrome, Delayed, Susceptibility To

Migraine, Familial Hemiplegic, 2

FHM2

Mhp2

Migraine, Familial Basilar

Familial Hemiplegic Migraine 2

Familial Hemiplegic Migraine-2

Familiar Basilar Migraine

Migraine, Hemiplegic, Familial, Type 2

Sleep Disorder

Sleep Disorders

Non-Organic Sleep Disorder

Migraine, Familial Hemiplegic, 3

FHM3

Familial Hemiplegic Migraine 3

Mhp3

Migraine, Hemiplegic, Familial, Type 3

Hepatocellular Carcinoma

Liver Cancer

Primary Liver Cancer

HCC

Hepatoma

Malignant Neoplasm Of Liver

Liver Neoplasms

Cancer, Hepatocellular

Liver Cell Carcinoma

Lcc

Hepatoblastoma, Somatic

Hepatic Cancer

Primary Malignant Neoplasm Of Liver

Rare Tumor Of Liver And Intrahepatic Biliary Tract

Hepatocellular Carcinoma, Somatic

Hepatocellular Carcinoma, Childhood Type, Somatic

Hepatocellular Cancer, Somatic

Ca Liver - Primary

Hepatic Neoplasm

Malignant Hepato-Biliary Neoplasm

Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary

Malignant Neoplasm Of Liver, Primary

Malignant Tumor Of Liver

Neoplasm Of Liver

Non-Resectable Primary Hepatic Malignant Neoplasm

Resectable Malignant Neoplasm Of Liver

Resectable Malignant Neoplasm Of The Liver

Primary Liver Carcinoma

Primary Malignant Liver Neoplasm

Primary Cancer Of Liver

Primary Tumor Of The Liver

Rare Tumor Of Liver And Ibt

Hepatocellular Cancer

Neoplasm Of The Liver

Carcinoma, Hepatocellular

Hepatomas

Liver Neoplasm

Liver Carcinoma

Liver And Intrahepatic Biliary Tract Carcinoma

Malignant Hepatobiliary Neoplasm

Adult Primary Hepatocellular Carcinoma

Hepatoblastoma

Carcinoma Of Liver

Malignant Liver Tumour

Malignant Hepatic Tumour

Major Depressive Disorder

Seasonal Affective Disorder

Unipolar Depression

Depression

MDD

Depressive Disorder

Unipolar Depression, Susceptibility To

Major Depressive Disorder 1

Major Depressive Disorder, Response To Citalopram Therapy In

Major Depressive Disorder 2

Winter Depression

Single Major Depressive Episode

Sad

Clinical Depression

Major Depression

Depressive Syndrome

Major Depressive Disorder And Accelerated Response To Antidepressant Drug Treatment

Seasonal Affective Disorder, Susceptibility To

Recurrent Major Depression

Affective Disorder, Seasonal

Depression In A Seasonal Pattern

Depression

Seasonal

Major Depressive Disorder With A Seasonal Pattern

Seasonal Depression

Seasonal Mood Disorder

Mental Depression

Recurrent Major Depressive Episodes

Breast Cancer

Breast Carcinoma

Male Breast Cancer

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation

Alzheimer Disease, Familial, 1

Alzheimer Disease

Alzheimer'S Disease

Presenile And Senile Dementia

AD1

Alzheimer Disease, Susceptibility To

Alzheimer Disease, Late-Onset, Susceptibility To

Alzheimer Disease 1, Familial

AD

Familial Alzheimer Disease

Alzheimer Disease, Late-Onset

Alzheimers Dementia

Alzheimer Dementia

Alzheimer Sclerosis

Alzheimer Syndrome

Alzheimer-Type Dementia

Dat

Primary Senile Degenerative Dementia

Sdat

Alzheimer Disease 1

Autosomal Dominant Alzheimer Disease

Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy

Late Onset Alzheimer Disease

Alzheimers Disease

Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy

Late-Onset Alzheimers Disease

Alzheimer'S Disease Pathway Kegg

Dementia Due To Alzheimer'S Disease

Alzheimer Disease Type 1

Alzheimers

Migraine With Or Without Aura 1

Migraine

Migraine With Or Without Aura, Susceptibility To, 1

Migraine Disorder

Migraine Variant

Migraines

Migraine Disorders

Mgr1

Mgau

Ma

Migraine With Or Without Aura

Classic Migraine

Common Migraine

Disorder, Migraine

Headache Migraine

Headache Migrainous

Migraine Headache

Migraine Syndrome

Headache Including Migraine

Migraine, Susceptibility To

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Canis familiaris CSNK1D VGNC VGNC:39667
Felis catus CSNK1D VGNC VGNC:97391
Macaca mulatta CSNK1D VGNC VGNC:81382
Mus musculus CSNK1D MGD MGI:1355272
Rattus norvegicus CSNK1D RGD RGD:71031
Bos taurus CSNK1D VGNC VGNC:27766
Others CSNK1D NCBI