2. Gene
  3. EVI5 - ecotropic viral integration site 5 Gene

EVI5 - ecotropic viral integration site 5 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：生态病毒整合位点 5

种属: Homo sapiens

同用名: NB4S; EVI-5

基因 ID: 7813 | 基因类型: protein coding

关于 EVI5

Cytogenetic location: 1p22.1 Genomic coordinates (GRCh38): 1:92,508,696-92,792,410 (from NCBI)

This gene has 9 transcripts (splice variants), 211 orthologues and 45 paralogues. Ubiquitous expression in testis (RPKM 3.8), placenta (RPKM 3.5) and 25 other tissues.

功能概要

启用 GTPase 激活剂活性和小 GTPase 结合活性。参与 GTPase 活性的正向调节和逆行转运，高尔基体的核内体。位于胞质溶胶中。 [由基因组资源联盟提供，2022 年 4 月]

Enables GTPase activator activity and small GTPase binding activity. Involved in positive regulation of GTPase activity and retrograde transport, endosome to Golgi. Located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]

EVI5 基因产物(8)

mRNA Protein Name
NM_001308248.2 NP_001295177.1 ecotropic viral integration site 5 protein homolog isoform 1
NM_001350197.2 NP_001337126.1 ecotropic viral integration site 5 protein homolog isoform 3
NM_001350198.2 NP_001337127.1 ecotropic viral integration site 5 protein homolog isoform 4
NM_001377210.1 NP_001364139.1 ecotropic viral integration site 5 protein homolog isoform 5
NM_001377211.1 NP_001364140.1 ecotropic viral integration site 5 protein homolog isoform 6
NM_001377212.1 NP_001364141.1 ecotropic viral integration site 5 protein homolog isoform 7
NM_001377213.1 NP_001364142.1 ecotropic viral integration site 5 protein homolog isoform 8
NM_005665.6 NP_005656.4 ecotropic viral integration site 5 protein homolog isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables GTPase activator activity IDA
IDA: 通过直接分析推断
17562788 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
16439210 GOA
enables small GTPase binding IPI
IPI: 通过物理相互作用推断
17562788 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in positive regulation of GTPase activity IDA
IDA: 通过直接分析推断
17562788 GOA
NOT involved in regulation of cilium assembly IMP
IMP: 通过突变表型推断
17646400 GOA
involved in retrograde transport, endosome to Golgi IMP
IMP: 通过突变表型推断
17562788 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytosol IDA
IDA: 通过直接分析推断
17562788 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

EVI5 蛋白结构

RabGAP-TBC

RabGAP-TBC: Rab-GTPase-TBC domain (167 - 368)

  • 0
  • 200
  • 400
  • 600
  • 810 a.a.
蛋白主名 其他名称

ecotropic viral integration site 5 protein homolog

dJ846D11.1 (ecotropic viral integration site 5)

EVI5 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra EVI5 O60447 MB21D2 Homo sapiens Q8IYB1
Anti Tag CoIP
33961781
Intra EVI5 O60447 MB21D2 Homo sapiens Q8IYB1
Validated Y2H
32296183
Intra EVI5 O60447 TCEANC Homo sapiens Q8N8B7-2
Validated Y2H
32296183
Intra EVI5 O60447 REP15 Homo sapiens Q6BDI9
Validated Y2H
32296183
Intra EVI5 O60447 PRPF31 Homo sapiens Q8WWY3
Validated Y2H
32296183
Intra EVI5 O60447 ARL4A Homo sapiens P40617
Validated Y2H
32296183
Intra EVI5 O60447 MCRS1 Homo sapiens Q96EZ8
Validated Y2H
32296183
Intra EVI5 O60447 MORF4L2 Homo sapiens Q15014
Validated Y2H
32296183
Intra EVI5 O60447 FAM161A Homo sapiens Q3B820
Validated Y2H
32296183
Intra EVI5 O60447 LENG1 Homo sapiens Q96BZ8
Validated Y2H
32296183
Intra EVI5 O60447 ZNF446 Homo sapiens Q9NWS9-2
Validated Y2H
32296183
Intra EVI5 O60447 CCDC185 Homo sapiens Q8N715
Validated Y2H
32296183
Intra EVI5 O60447 CEP19 Homo sapiens Q96LK0
Validated Y2H
32296183
Intra EVI5 O60447 ELOA Homo sapiens Q14241
Validated Y2H
32296183
Intra EVI5 O60447 RAB11A Homo sapiens P62491
SPR
17229837
Intra EVI5 O60447 RAB11A Homo sapiens P62491
Y2H
17229837
Intra EVI5 O60447 RAB11A Homo sapiens P62491
Pull Down
17229837
Intra EVI5 O60447 RAB11A Homo sapiens P62491
Anti Bait CoIP
17229837
Intra EVI5 O60447 IMP3 Homo sapiens Q9NV31
Validated Y2H
32296183
Intra EVI5 O60447 CSNK1D Homo sapiens P48730
Validated Y2H
32296183
Intra EVI5 O60447 TNFAIP8L1 Homo sapiens Q8WVP5
Validated Y2H
32296183
Intra EVI5 O60447 FBXO5 Homo sapiens Q9UKT4
Anti Bait CoIP
16439210
Intra EVI5 O60447 FBXO5 Homo sapiens Q9UKT4
Anti Tag CoIP
16439210
Intra EVI5 O60447 LMO1 Homo sapiens P25800
Validated Y2H
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Neuroblastoma

Nb

Neuroblastoma, Susceptibility To

Neuroblastomas

Central Neuroblastoma
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS04576 EVI5 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta EVI5 VGNC VGNC:99919
Bos taurus EVI5 VGNC VGNC:55170
Rattus norvegicus EVI5 RGD RGD:2322879
Mus musculus EVI5 MGD MGI:104736
Felis catus EVI5 VGNC VGNC:80209
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