1. Gene
  2. FBXO5 - F-box protein 5 Gene

FBXO5 - F-box protein 5 Gene

中文名称:F 盒蛋白 5

种属: Homo sapiens

同用名: EMI1; FBX5; Fbxo31

基因 ID: 26271 | 基因类型: protein coding

关于 FBXO5

Cytogenetic location: 6q25.2 Genomic coordinates (GRCh38): 6:152,970,535-152,983,579 (from NCBI)

This gene has 3 transcripts (splice variants), 195 orthologues and 1 paralogue. Broad expression in bone marrow (RPKM 14.0), lymph node (RPKM 6.9) and 22 other tissues.

功能概要

该基因编码 F-box 蛋白家族的一个成员,其特征在于大约 40 个氨基酸基序,即 F-box。 F-box 蛋白构成称为 SCF (SKP1-cullin-F-box) 的泛素蛋白连接酶复合物的四个亚基之一,其在磷酸化依赖性泛素化中发挥作用。 F-box 蛋白分为 3 类:包含 WD-40 结构域的 Fbws、包含富含亮氨酸重复序列的 Fbls 和包含不同蛋白质-蛋白质相互作用模块或无可识别基序的 Fbxs。该基因编码的蛋白质属于 Fbxs 类。这种蛋白质类似于非洲爪蟾早期有丝分裂抑制剂-1 (Emi1) ,它是一种与 Cdc20 相互作用并抑制后期促进复合物的有丝分裂调节剂。已经鉴定出编码不同亚型的选择性剪接转录物变体。[RefSeq 提供,2008 年 12 月]

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein Ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. This protein is similar to xenopus early mitotic inhibitor-1 (Emi1), which is a mitotic regulator that interacts with Cdc20 and inhibits the anaphase promoting complex. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Dec 2008]

FBXO5 基因产物(2)

mRNA Protein Name
NM_001142522.3 NP_001135994.1 F-box only protein 5 isoform b
NM_012177.5 NP_036309.1 F-box only protein 5 isoform a
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables anaphase-promoting complex binding IDA
IDA: 通过直接分析推断
16921029 GOA
enables molecular function inhibitor activity IDA
IDA: 通过直接分析推断
23708605 GOA
enables molecular function inhibitor activity IMP
IMP: 通过突变表型推断
23708605 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
11988738 GOA
enables protein kinase binding IPI
IPI: 通过物理相互作用推断
15148369 GOA
enables ubiquitin ligase inhibitor activity IDA
IDA: 通过直接分析推断
15148369 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
11988738 GOA
located in nucleus IDA
IDA: 通过直接分析推断
11988738 GOA
located in spindle IDA
IDA: 通过直接分析推断
15469984 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

FBXO5 蛋白结构

F-box

F-box: F-box domain (258 - 289)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 447 a.a.
蛋白主名 其他名称

F-box only protein 5

F-box protein Fbx5

FBXO5 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra FBXO5 Q9UKT4 EVI5 Homo sapiens O60447
Anti Tag CoIP
16439210
Intra FBXO5 Q9UKT4 EVI5 Homo sapiens O60447
Pull Down
16439210
Intra FBXO5 Q9UKT4 CDC27 Homo sapiens P30260
Anti Tag CoIP
33961781
Intra FBXO5 Q9UKT4 CDC27 Homo sapiens P30260
Anti Bait CoIP
17719540
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Aleutian Mink Disease

Aleutian Disease

Arthrogryposis Multiplex Congenita 2, Neurogenic Type

Arthrogryposis Multiplex Congenita, Neurogenic Type

Amcn

Arthrogryposis Multiplex Congenita Neurogenic Type

AMC2

Amc, Neurogenic Type

Neurogenic-Type Arthrogryposis Multiplex Congenita-2

Amc Neurogenic Type

Neurogenic Type Of Amc

Neurogenic Arthrogryposis Multiplex Congenita

Arthrogryposis Multiplex Congenita, Neurogenic

Lung Cancer

Lung Carcinoma

Non-Small Cell Lung Carcinoma

Lung Cancer, Susceptibility To

Lung Cancer, Protection Against

Adenocarcinoma Of Lung, Somatic

Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer

Lung Neoplasm

Carcinoma Of Lung

Lung Non-Small Cell Carcinoma

Non-Small Cell Lung Cancer

Nsclc

Lung Neoplasms

Malignant Neoplasm Of Lung

Alveolar Cell Carcinoma

Nonsmall Cell Lung Cancer, Somatic

Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer, Susceptibility To

Lung Cancer, Somatic

Lung Cancer, Resistance To

Cancer Of Lung

Cancer Of Bronchus

Cancer Of The Lung

Lung Malignancies

Lung Malignant Tumors

Malignant Lung Tumor

Malignant Tumor Of Lung

Pulmonary Cancer

Pulmonary Carcinoma

Pulmonary Neoplasms

Respiratory Carcinoma

LNCR

Adenocarcinoma Of Lung

Neoplasm Of Lung

Cancer Lung

Carcinoma Non-Small Cell Lung

Carcinoma, Non-Small-Cell Lung

Lung Cancers

Lung Carcinomas

Cancer, Lung

Cancer, Lung, Non-Small Cell

Primary Malignant Neoplasm Of Lung

Bronchioloalveolar Adenocarcinoma

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Felis catus FBXO5 VGNC VGNC:62196
Canis familiaris FBXO5 VGNC VGNC:40787
Mus musculus FBXO5 MGD MGI:1914391
Macaca mulatta FBXO5 VGNC VGNC:72489
Rattus norvegicus FBXO5 RGD RGD:1309405
Bos taurus FBXO5 VGNC VGNC:28917