CDC27 - cell division cycle 27 Gene

中文名称：细胞分裂周期 27

种属: Homo sapiens

同用名: APC3; HNUC; NUC2; H-NUC; ANAPC3; CDC27Hs; D0S1430E; D17S978E

基因 ID: 996 | 基因类型: protein coding

关于 CDC27

Cytogenetic location: 17q21.32 Genomic coordinates (GRCh38): 17:47,117,703-47,189,295 (from NCBI)

This gene has 19 transcripts (splice variants), 205 orthologues and 3 paralogues. Ubiquitous expression in thyroid (RPKM 20.3), testis (RPKM 11.6) and 25 other tissues.

功能概要

该基因编码的蛋白与酿酒酵母蛋白 Cdc27、粟酒裂殖酵母 nuc 2 的基因产物具有很强的相似性。该蛋白是后期促进复合物 (APC) 的组成部分，由 8 个蛋白亚基组成，高度在真核细胞中保存。该复合物催化细胞周期蛋白 B-泛素结合物的形成，它负责泛素介导的 B 型细胞周期蛋白的蛋白水解。由该基因和 APC 复合体的其他三个成员编码的蛋白质包含四肽 (TPR) 重复序列，这对于蛋白质-蛋白质相互作用很重要。该蛋白被证明与有丝分裂检查点蛋白相互作用，包括 Mad2、p55CDC 和 BUBR1，因此它可能参与控制有丝分裂的时间。该基因的可变剪接导致多个转录变体。已在 2 号、22 号和 Y 号染色体上鉴定出相关的假基因。[RefSeq 提供，2014 年 5 月]

The protein encoded by this gene shares strong similarity with Saccharomyces cerevisiae protein Cdc27, and the gene product of Schizosaccharomyces pombe nuc 2. This protein is a component of the anaphase-promoting complex (APC), which is composed of eight protein subunits and is highly conserved in eukaryotic cells. This complex catalyzes the formation of cyclin B-ubiquitin conjugate, which is responsible for the ubiquitin-mediated proteolysis of B-type cyclins. The protein encoded by this gene and three Other members of the APC complex contain tetratricopeptide (TPR) repeats, which are important for protein-protein interactions. This protein was shown to interact with mitotic checkpoint proteins including Mad2, p55CDC and BUBR1, and it may thus be involved in controlling the timing of mitosis. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 2, 22 and Y. [provided by RefSeq, May 2014]

CDC27 基因产物(9)

mRNA	Protein	Name
NM_001114091.4	NP_001107563.1	cell division cycle protein 27 homolog isoform 1
NM_001256.6	NP_001247.3	cell division cycle protein 27 homolog isoform 2
NM_001293089.3	NP_001280018.1	cell division cycle protein 27 homolog isoform 3
NM_001293091.3	NP_001280020.1	cell division cycle protein 27 homolog isoform 4
NM_001353035.2	NP_001339964.1	cell division cycle protein 27 homolog isoform 5
NM_001353047.2	NP_001339976.1	cell division cycle protein 27 homolog isoform 6
NM_001353049.2	NP_001339978.1	cell division cycle protein 27 homolog isoform 7
NM_001353050.2	NP_001339979.1	cell division cycle protein 27 homolog isoform 8
NM_001353051.2	NP_001339980.1	cell division cycle protein 27 homolog isoform 9

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	10548110	GOA
enables protein phosphatase binding	IPI IPI: 通过物理相互作用推断	21241890	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in anaphase-promoting complex-dependent catabolic process	IDA IDA: 通过直接分析推断	29033132	GOA
acts upstream of or within metaphase/anaphase transition of mitotic cell cycle	IMP IMP: 通过突变表型推断	7736578	GOA
involved in protein K11-linked ubiquitination	IDA IDA: 通过直接分析推断	18485873	GOA
involved in protein K48-linked ubiquitination	IDA IDA: 通过直接分析推断	29033132	GOA
involved in protein branched polyubiquitination	IDA IDA: 通过直接分析推断	29033132	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of anaphase-promoting complex	IDA IDA: 通过直接分析推断	16364912	GOA
part of anaphase-promoting complex	IPI IPI: 通过物理相互作用推断	27120157	GOA
located in centrosome	IDA IDA: 通过直接分析推断	7736578	GOA
located in mitotic spindle	IDA IDA: 通过直接分析推断	7736578	GOA
located in nucleus	IDA IDA: 通过直接分析推断	18445686	GOA
located in spindle	IDA IDA: 通过直接分析推断	18445686	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CDC27 蛋白结构

ANAPC3

TPR_1

TPR_11

TPR_1

TPR_11

0
200
400
600
824 a.a.

蛋白主名

其他名称

cell division cycle protein 27 homolog

D0S1430E, D17S978E

CDC27 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	CDC27	P30260	COMT	Homo sapiens	P21964-2	Y2H Prey Pooling	25416956
种属内	CDC27	P30260	COMT	Homo sapiens	P21964-2	Y2H Array	25416956
种属内	CDC27	P30260	FOXO3	Homo sapiens	O43524	Pull Down	25609649
种属内	CDC27	P30260	ANAPC4	Homo sapiens	Q9UJX5	Anti Tag CoIP	35271311
种属内	CDC27	P30260	ANAPC4	Homo sapiens	Q9UJX5	Anti Bait CoIP	26496610
种属内	CDC27	P30260	ANAPC4	Homo sapiens	Q9UJX5	Anti Bait CoIP	21241890
种属内	CDC27	P30260	ANAPC4	Homo sapiens	Q9UJX5	Anti Bait CoIP	20360068
种属内	CDC27	P30260	CDC20	Homo sapiens	Q12834	Anti Tag CoIP	22014574
种属内	CDC27	P30260	CDC20	Homo sapiens	Q12834	Anti Bait CoIP	17443180
种属内	CDC27	P30260	CDC20	Homo sapiens	Q12834	Anti Bait CoIP	20212161
种属内	CDC27	P30260	CDC20	Homo sapiens	Q12834	Anti Bait CoIP	21300909
种属内	CDC27	P30260	CDC20	Homo sapiens	Q12834	Anti Tag CoIP	35271311
种属内	CDC27	P30260	CDC20	Homo sapiens	Q12834	Anti Bait CoIP	22014574
种属内	CDC27	P30260	CDC20	Homo sapiens	Q12834	Anti Bait CoIP	17443186
种属内	CDC27	P30260	CDC20	Homo sapiens	Q12834	Anti Bait CoIP	20951947
种属内	CDC27	P30260	NEK2	Homo sapiens	P51955	Anti Bait CoIP	16648845
种属内	CDC27	P30260	NEK2	Homo sapiens	P51955	Anti Tag CoIP	35271311
种属内	CDC27	P30260	PTEN	Homo sapiens	P60484	Anti Bait CoIP	21241890
种属内	CDC27	P30260	PTEN	Homo sapiens	P60484	IF	21241890
种属内	CDC27	P30260	PTEN	Homo sapiens	P60484	Anti Tag CoIP	21241890
种属内	CDC27	P30260	FZR1	Homo sapiens	Q9UM11	Anti Bait CoIP	21241890
种属内	CDC27	P30260	FZR1	Homo sapiens	Q9UM11	Anti Bait CoIP	21186364
种属内	CDC27	P30260	FZR1	Homo sapiens	Q9UM11	Anti Bait CoIP	18662541
种属内	CDC27	P30260	FZR1	Homo sapiens	Q9UM11	Anti Bait CoIP	22014574
种属内	CDC27	P30260	CDH1	Homo sapiens	P12830	Immunodepletion CoIP	20802534
种属内	CDC27	P30260	MAD2L2	Homo sapiens	Q9UI95	Anti Bait CoIP	17719540
种属内	CDC27	P30260	MAD2L1	Homo sapiens	Q13257	Anti Bait CoIP	20951947
种属内	CDC27	P30260	MAD2L1	Homo sapiens	Q13257	Anti Bait CoIP	17443180
种属内	CDC27	P30260	MAD2L1	Homo sapiens	Q13257	Anti Bait CoIP	20212161
种属内	CDC27	P30260	MAD2L1	Homo sapiens	Q13257	Anti Bait CoIP	21300909
种属内	CDC27	P30260	MAD2L1	Homo sapiens	Q13257	Anti Bait CoIP	17443186
种属内	CDC27	P30260	FBXO5	Homo sapiens	Q9UKT4	Anti Bait CoIP	18662541

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Glandular Tularemia

Pyomyositis

Tropical Pyomyositis	Myositis Tropicans
Myositis Purulenta Tropica	Pm
Suppurative Myositis	Purulent Myositis

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS02295	CDC27 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS16279	Human CDC27P9 Pre-designed siRNA Set A		/	否
HY-RS16274	Human CDC27P10 Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Felis catus	CDC27	VGNC	VGNC:60653
Mus musculus	CDC27	MGD	MGI:102685
Rattus norvegicus	CDC27	RGD	RGD:1304921
Bos taurus	CDC27	VGNC	VGNC:50040
Canis familiaris	CDC27	VGNC	VGNC:53202
Macaca mulatta	CDC27	VGNC	VGNC:70797

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