2. Gene
  3. FZR1 - fizzy and cell division cycle 20 related 1 Gene

FZR1 - fizzy and cell division cycle 20 related 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：fizzy 和细胞分裂周期 20 相关 1

种属: Homo sapiens

同用名: FZR; CDH1; FZR2; HCDH; HCDH1; CDC20C; DEE109

基因 ID: 51343 | 基因类型: protein coding

关于 FZR1

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:3,506,311-3,538,334 (from NCBI)

This gene has 9 transcripts (splice variants), 260 orthologues, 2 paralogues and is associated with 1 phenotype. Ubiquitous expression in testis (RPKM 11.7), bone marrow (RPKM 10.3) and 25 other tissues.

功能概要

预计可实现后期促进复合物结合活性和泛素连接酶激活剂活性。参与后期促进复合物依赖性分解代谢过程；有丝分裂 G2 DNA 损伤检查点信号；和蛋白质代谢过程的积极调节。位于核膜和核质中。与后期促进复合体共定位。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable anaphase-promoting complex binding activity and ubiquitin Ligase activator activity. Involved in anaphase-promoting complex-dependent catabolic process; mitotic G2 DNA damage checkpoint signaling; and positive regulation of protein metabolic process. Located in nuclear membrane and nucleoplasm. Colocalizes with anaphase-promoting complex. [provided by Alliance of Genome Resources, Apr 2022]

FZR1 基因产物(3)

mRNA Protein Name
NM_001136197.1 NP_001129669.1 fizzy-related protein homolog isoform 3
NM_001136198.1 NP_001129670.1 fizzy-related protein homolog isoform 1
NM_016263.4 NP_057347.2 fizzy-related protein homolog isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
10548110 GOA
enables ubiquitin-like ligase-substrate adaptor activity IDA
IDA: 通过直接分析推断
14701726 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in anaphase-promoting complex-dependent catabolic process IDA
IDA: 通过直接分析推断
14701726 GOA
involved in mitotic G2 DNA damage checkpoint signaling IDA
IDA: 通过直接分析推断
18662541 GOA
involved in positive regulation of ubiquitin protein ligase activity IDA
IDA: 通过直接分析推断
11459826 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in nucleus IDA
IDA: 通过直接分析推断
34788397 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

FZR1 蛋白结构

WD40

WD40: WD domain, G-beta repeat (230 - 257)

WD40

WD40: WD domain, G-beta repeat (262 - 293)

WD40

WD40: WD domain, G-beta repeat (307 - 341)

WD40

WD40: WD domain, G-beta repeat (347 - 386)

WD40

WD40: WD domain, G-beta repeat (435 - 471)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 496 a.a.
蛋白主名 其他名称

fizzy-related protein homolog

CDC20 homolog 1

FZR1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
FZR1 Q9UM11 CLSPN Homo sapiens Q9HAW4
Anti Tag CoIP
18662541
种属内
FZR1 Q9UM11 CLSPN Homo sapiens Q9HAW4
Pull Down
18662541
种属内
FZR1 Q9UM11 RRM2 Homo sapiens P31350
Anti Tag CoIP
33961781
种属内
FZR1 Q9UM11 VHL Homo sapiens P40337
Anti Bait CoIP
20802534
种属内
FZR1 Q9UM11 VHL Homo sapiens P40337-3
Anti Bait CoIP
20802534
种属内
FZR1 Q9UM11 VHL Homo sapiens P40337-1
Pull Down
20802534
种属内
FZR1 Q9UM11 VHL Homo sapiens P40337-1
Anti Bait CoIP
20802534
种属内
FZR1 Q9UM11 MAK Homo sapiens P20794
Anti Bait CoIP
21986944
种属内
FZR1 Q9UM11 MAK Homo sapiens P20794
Protein Kinase Assay
21986944
种属内
FZR1 Q9UM11 SKP2 Homo sapiens Q13309
Anti Tag CoIP
33961781
种属内
FZR1 Q9UM11 MAD2L2 Homo sapiens Q9UI95
Pull Down
17719540
种属内
FZR1 Q9UM11 RAD17 Homo sapiens O75943
Anti Bait CoIP
20424596
种属内
FZR1 Q9UM11 CDC27 Homo sapiens P30260
Anti Tag CoIP
18662541
种属内
FZR1 Q9UM11 CDC27 Homo sapiens P30260
Anti Tag CoIP
22014574
种属内
FZR1 Q9UM11 CDC27 Homo sapiens P30260
Anti Tag CoIP
33961781
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Breast Cancer

Breast Carcinoma

Male Breast Cancer

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS05186 FZR1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus FZR1 VGNC VGNC:62408
Canis familiaris FZR1 VGNC VGNC:41036
Macaca mulatta FZR1 VGNC VGNC:72774
Bos taurus FZR1 VGNC VGNC:29173
Rattus norvegicus FZR1 RGD RGD:1308713
Mus musculus FZR1 MGD MGI:1926790
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