2. Gene
  3. CDC20 - cell division cycle 20 Gene

CDC20 - cell division cycle 20 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：细胞分裂周期 20

种属: Homo sapiens

同用名: CDC20A; p55CDC; bA276H19.3

基因 ID: 991 | 基因类型: protein coding

关于 CDC20

Cytogenetic location: 1p34.2 Genomic coordinates (GRCh38): 1:43,358,981-43,363,203 (from NCBI)

This gene has 4 transcripts (splice variants), 220 orthologues and 2 paralogues. Biased expression in testis (RPKM 26.5), bone marrow (RPKM 19.7) and 12 other tissues.

功能概要

CDC20 似乎充当调节蛋白，在细胞周期的多个点与其他几种蛋白质相互作用。它是两个微管依赖过程所必需的，即后期和染色体分离之前的核运动。[RefSeq 提供，2008 年 7 月]

CDC20 appears to act as a regulatory protein interacting with several Other proteins at multiple points in the cell cycle. It is required for two microtubule-dependent processes, nuclear movement prior to anaphase and chromosome separation. [provided by RefSeq, Jul 2008]

CDC20 基因产物(1)

mRNA Protein Name
NM_001255.3 NP_001246.2 cell division cycle protein 20 homolog
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables anaphase-promoting complex binding IDA
IDA: 通过直接分析推断
14743218 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
10700282 GOA
enables ubiquitin-like ligase-substrate adaptor activity IDA
IDA: 通过直接分析推断
27030811 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in anaphase-promoting complex-dependent catabolic process IDA
IDA: 通过直接分析推断
17443180 GOA
involved in metaphase/anaphase transition of meiosis I IMP
IMP: 通过突变表型推断
32666501 GOA
involved in positive regulation of mitotic metaphase/anaphase transition IDA
IDA: 通过直接分析推断
9637688 GOA
involved in positive regulation of ubiquitin protein ligase activity IDA
IDA: 通过直接分析推断
11459826 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of anaphase-promoting complex IDA
IDA: 通过直接分析推断
11459825 GOA
part of mitotic checkpoint complex IPI
IPI: 通过物理相互作用推断
27509861 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CDC20 蛋白结构

WD40

WD40: WD domain, G-beta repeat (302 - 336)

WD40

WD40: WD domain, G-beta repeat (345 - 386)

WD40

WD40: WD domain, G-beta repeat (436 - 470)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 499 a.a.
蛋白主名 其他名称

cell division cycle protein 20 homolog

CDC20 cell division cycle 20 homolog

CDC20 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
CDC20 Q12834 ANAPC4 Homo sapiens Q9UJX5
Anti Bait CoIP
25383541
种属内
CDC20 Q12834 ANAPC4 Homo sapiens Q9UJX5
TAP
20360068
种属内
CDC20 Q12834 ANAPC4 Homo sapiens Q9UJX5
Anti Tag CoIP
25383541
种属内
CDC20 Q12834 RASSF1 Homo sapiens Q9NS23-2
CoIP
14743218
种属间
CDC20 Q12834 Axin2 Mus musculus O88566
Anti Tag CoIP
22322943
种属内
CDC20 Q12834 MAD2L1 Homo sapiens Q13257
Anti Bait CoIP
15182668
种属内
CDC20 Q12834 MAD2L1 Homo sapiens Q13257
Anti Bait CoIP
21407176
种属内
CDC20 Q12834 MAD2L1 Homo sapiens Q13257
Anti Bait CoIP
22340593
种属内
CDC20 Q12834 MAD2L1 Homo sapiens Q13257
Anti Bait CoIP
24581499
种属内
CDC20 Q12834 MAD2L1 Homo sapiens Q13257
Anti Bait CoIP
37926298
种属内
CDC20 Q12834 MAD2L1 Homo sapiens Q13257
Pull Down
18022367
种属内
CDC20 Q12834 MAD2L1 Homo sapiens Q13257
Anti Tag CoIP
25383541
种属内
CDC20 Q12834 MAD2L1 Homo sapiens Q13257
TAP
20360068
种属内
CDC20 Q12834 MAD2L1 Homo sapiens Q13257
Anti Tag CoIP
33961781
种属内
CDC20 Q12834 MAD2L1 Homo sapiens Q13257
Anti Bait CoIP
20212161
种属内
CDC20 Q12834 MAD2L1 Homo sapiens Q13257
Pull Down
17443186
种属内
CDC20 Q12834 CDC27 Homo sapiens P30260
TAP
20360068
种属内
CDC20 Q12834 CDC27 Homo sapiens P30260
Anti Bait CoIP
17443186
种属内
CDC20 Q12834 CDC27 Homo sapiens P30260
Anti Bait CoIP
24781523
种属内
CDC20 Q12834 CDC27 Homo sapiens P30260
Anti Tag CoIP
22014574
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Mosaic Variegated Aneuploidy Syndrome 1

Mva Syndrome

MVA1

Mosaic Variegated Aneuploidy Syndrome, Type 1

Mosaic Variegated Aneuploidy Syndrome

Congenital Chromosomal Disease
Mosaic Variegated Aneuploidy Syndrome

Warburton-Anyane-Yeboa Syndrome

Mva Syndrome

Mosaic Variegated Aneuplody Microcephaly Syndrome

Warburton Anyane Yeboa Syndrome
Prostate Cancer

Prostate Carcinoma

Prostate Cancer, Familial

Prostate Neoplasm

Prostate Cancer, Somatic

Prostate Cancer, Susceptibility To

Prostatic Cancer

Prostatic Neoplasms

Hereditary Prostate Cancer

Prostatic Neoplasm

Cancer Of Prostate

Carcinoma Of Prostate

Familial Prostate Cancer

Familial Prostate Carcinoma

Malignant Tumor Of Prostate

Malignant Neoplasm Of Prostate

Prostate Cancer, Familial, Susceptibility To

Malignant Tumor Of The Prostate

Ngp - New Growth Of Prostate

Tumor Of The Prostate

Prostate Cancer, Hereditary

Cancer Of The Prostate

Malignant Neoplasm Of The Prostate

Prostatic Carcinoma

PC

Prca

Cancer, Prostate

Malignant Prostatic Tumour

Malignant Tumour Of Prostate

Primary Prostate Cancer

Primary Malignant Neoplasm Of Prostate

Prostate Gland Cancer
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (12)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-110287 Apcin Inhibitor 99.71% 否
HY-130257 CP5V Inhibitor 99.31% 否
HY-100341 M2I-1 Inhibitor ≥98.0% 否
HY-116006 Bis-PEG5-acid 95.77% 否
HY-130841 Apcin-A Inhibitor ≥98.0% 否
HY-13255 TAME Inhibitor 99.51% 否
HY-131959 (S,R,S)-AHPC-PEG5-Boc 95.29% 否
HY-13255A TAME hydrochloride Inhibitor 98.31% 否
HY-161257 CDC20-IN-1 Inducer / 否
HY-RS02288 CDC20 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS02289 CDC20B Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-W614725 Apcin-A monohydrochloride Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus CDC20 VGNC VGNC:107502
Rattus norvegicus CDC20 RGD RGD:620477
Mus musculus CDC20 MGD MGI:1859866
Bos taurus CDC20 VGNC VGNC:27060
Canis familiaris CDC20 VGNC VGNC:38987
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